Targeting NETs using dual-active DNase1 variants
Englert H, Göbel J, Khong D, Omidi M, Wolska N, Konrath S, Frye M, Mailer R, Beerens M, Gerwers J, Preston R, Odeberg J, Butler L, Maas C, Stavrou E, Fuchs T, Renné T
FRONT IMMUNOL. 2023;14:1181761.

The role of platelets in thrombus fibrosis and vessel wall remodeling after venous thrombosis
DeRoo E, Martinod K, Cherpokova D, Fuchs T, Cifuni S, Chu L, Staudinger C, Wagner D
J THROMB HAEMOST. 2021;19(2):387-399.

Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy
Xiong T, Attar M, Gnirck A, Wunderlich M, Becker M, Rickassel C, Puelles V, Meyer-Schwesinger C, Wiech T, Nies J, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber T, Panzer U, Turner J
KIDNEY INT. 2020;98(3):615-629.

Metabolic Activity in Central Neural Structures of Patients With Myocardial Injury
Fiechter M, Roggo A, Haider A, Bengs S, Burger I, Marędziak M, Portmann A, Treyer V, Becker A, Messerli M, Mühlematter U, Kudura K, von Felten E, Benz D, Fuchs T, Gräni C, Pazhenkottil A, Buechel R, Kaufmann P, Gebhard C
J AM HEART ASSOC. 2019;8(19):e013070.

Neutrophil Extracellular Traps Initiate Gallstone Formation
Muñoz L, Boeltz S, Bilyy R, Schauer C, Mahajan A, Widulin N, Grüneboom A, Herrmann I, Boada E, Rauh M, Krenn V, Biermann M, Podolska M, Hahn J, Knopf J, Maueröder C, Paryzhak S, Dumych T, Zhao Y, Neurath M, Hoffmann M, Fuchs T, Leppkes M, Schett G, Herrmann M
IMMUNITY. 2019;51(3):443-450.e4.

Neutrophil Extracellular Traps
Fuchs T, Hakkim A, Urban C
2018. Inflammation: Fundamental Mechanisms. Ley K (eds.). 1. ed. World Scientific Publishing Co. Pte Ltd, 205-276.

Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism
Jiménez-Alcázar M, Limacher A, Panda R, Méan M, Bitterling J, Peine S, Renné T, Beer J, Aujesky D, Lämmle B, Fuchs T
PLOS ONE. 2018;13(2):e0191150.

What a drag - necrotic platelets induce remote neutrophil thrombi following ischemic gut injury
Martinod K, Fuchs T
J THROMB HAEMOST. 2018;16(5):819-821.

Neutrophil Extracellular Traps Open the Pandora's Box in Severe Malaria
Boeltz S, Muñoz L, Fuchs T, Herrmann M
FRONT IMMUNOL. 2017;8:874.

Therapeutic targeting of extracellular DNA improves the outcome of intestinal ischemic reperfusion injury in neonatal rats
Boettcher M, Eschenburg G, Mietzsch S, Jiménez-Alcázar M, Klinke M, Vincent D, Tiemann B, Bergholz R, Reinshagen K, Fuchs T
SCI REP-UK. 2017;7(1):15377.

Degradation of Extracellular DNA by DNase1 Significantly Reduces Testicular Damage after Testicular Torsion in Rats
Boettcher M, Meier D, Jiménez-Alcázar M, Eschenburg G, Mietzsch S, Vincent D, Klinke M, Trochimiuk M, Appl B, Tiemann B, Bergholz R, Reinshagen K, Fuchs T
UROLOGY. 2017;109:223.e1-223.e7.

Circulating Extracellular DNA: Cause or Consequence of Thrombosis?
Jiménez-Alcázar M, Kim N, Fuchs T
SEMIN THROMB HEMOST. 2017;43(6):553-561.

Host DNases prevent vascular occlusion by neutrophil extracellular traps
Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek Y, Long A, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz H, Kitamura D, Herrmann M, Napirei M, Fuchs T
SCIENCE. 2017;358(6367):1202-1206.

A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury
Kleinschmidt D, Giannou A, McGee H, Kempski J, Steglich B, Huber F, Ernst T, Shiri A, Wegscheid C, Tasika E, Hübener P, Huber P, Bedke T, Steffens N, Agalioti T, Fuchs T, Noll J, Lotter H, Tiegs G, Lohse A, Axelrod J, Galun E, Flavell R, Gagliani N, Huber S
J IMMUNOL. 2017;199(12):4078-4090.

Missing in action-The meaning of cell death in tissue damage and inflammation
Muñoz L, Leppkes M, Fuchs T, Hoffmann M, Herrmann M
IMMUNOL REV. 2017;280(1):26-40.

Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases
Nickel K, Long A, Fuchs T, Butler L, Renné T
ARTERIOSCL THROM VAS. 2017;37(1):13-20.

Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies
Panda R, Krieger T, Hopf L, Renné T, Haag F, Röber N, Conrad K, Csernok E, Fuchs T
FRONT IMMUNOL. 2017;8:439.

Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion
Boettcher M, Fuchs T, Schäfer H, Appl B, Trochimiuk M, Jiménez-Alcázar M, Tiemann B, Jung R, Bergholz R, Reinshagen K, Eschenburg G
UROLOGY. 2016;88(227):e1-7.

Contact system revisited: an interface between inflammation, coagulation, and innate immunity
Long A, Kenne E, Jung R, Fuchs T, Renné T
J THROMB HAEMOST. 2016;14(3):427-37.

The polyphosphate/factor XII pathway in cancer-associated thrombosis: novel perspectives for safe anticoagulation in patients with malignancies
Nickel K, Labberton L, Long A, Langer F, Fuchs T, Stavrou E, Butler L, Renné T
THROMB RES. 2016;141 Suppl 2:S4-7.

Tissue factor-dependent and -independent pathways of systemic coagulation activation in acute myeloid leukemia: a single-center cohort study
Dicke C, Amirkhosravi A, Spath B, Jiménez-Alcázar M, Fuchs T, Davila M, Francis J, Bokemeyer C, Langer F
EXP HEMATOL ONCOL. 2015;4:22.

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies
Jiménez-Alcázar M, Napirei M, Panda R, Köhler E, Kremer Hovinga J, Mannherz H, Peine S, Renné T, Lämmle B, Fuchs T
J THROMB HAEMOST. 2015;13(5):732-42.

Factor XII: a novel target for safe prevention of thrombosis and inflammation
Kenne E, Nickel K, Long A, Fuchs T, Stavrou E, Stahl F, Renné T
J INTERN MED. 2015;278(6):571-85.

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock
Martinod K, Fuchs T, Zitomersky N, Wong S, Demers M, Gallant M, Wang Y, Wagner D
BLOOD. 2015;125(12):1948-56.

The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis
Nickel K, Ronquist G, Langer F, Labberton L, Fuchs T, Bokemeyer C, Sauter G, Graefen M, Mackman N, Stavrou E, Ronquist G, Renné T
BLOOD. 2015;126(11):1379-89.

Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions
Sala-Cunill A, Björkqvist J, Senter R, Guilarte M, Cardona V, Labrador M, Nickel K, Butler L, Luengo O, Kumar P, Labberton L, Long A, Di Gennaro A, Kenne E, Jämsä A, Krieger T, Schlüter H, Fuchs T, Flohr S, Hassiepen U, Cumin F, McCrae K, Maas C, Stavrou E, Renné T
J ALLERGY CLIN IMMUN. 2015;135(4):1031-1043.e6.

The factor XIIa blocking antibody 3F7: a safe anticoagulant with anti-inflammatory activities
Worm M, Köhler E, Panda R, Long A, Butler L, Stavrou E, Nickel K, Fuchs T, Renné T
J TRANSL MED. 2015;3(17):247.

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
Chen G, Zhang D, Fuchs T, Manwani D, Wagner D, Frenette P
BLOOD. 2014;123(24):3818-27.

Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state
Borissoff J, Joosen I, Versteylen M, Brill A, Fuchs T, Savchenko A, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns H, Wagner D, Kietselaer B
ARTERIOSCL THROM VAS. 2013;33(8):2032-40.

Plasma DNA is Elevated in Patients with Deep Vein Thrombosis
Diaz J, Fuchs T, Jackson T, Kremer Hovinga J, Lämmle B, Henke P, Myers D, Wagner D, Wakefield T
J VASC SURG. 2013;1(4):.

Neutrophils release extracellular DNA traps during storage of red blood cell units
Fuchs T, Alvarez J, Martinod K, Bhandari A, Kaufman R, Wagner D
TRANSFUSION. 2013;53(12):3210-6.

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice
Martinod K, Demers M, Fuchs T, Wong S, Brill A, Gallant M, Hu J, Wang Y, Wagner D
P NATL ACAD SCI USA. 2013;110(21):8674-9.

Neutrophil extracellular traps promote deep vein thrombosis in mice
Brill A, Fuchs T, Savchenko A, Thomas G, Martinod K, De Meyer S, Bhandari A, Wagner D
J THROMB HAEMOST. 2012;10(1):136-44.

Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice
Brill A, Yesilaltay A, De Meyer S, Kisucka J, Fuchs T, Kocher O, Krieger M, Wagner D
ARTERIOSCL THROM VAS. 2012;32(8):1841-7.

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis
Demers M, Krause D, Schatzberg D, Martinod K, Voorhees J, Fuchs T, Scadden D, Wagner D
P NATL ACAD SCI USA. 2012;109(32):13076-81.

Extracellular chromatin is an important mediator of ischemic stroke in mice
De Meyer S, Suidan G, Fuchs T, Monestier M, Wagner D
ARTERIOSCL THROM VAS. 2012;32(8):1884-91.

Neutrophil extracellular trap (NET) impact on deep vein thrombosis
Fuchs T, Brill A, Wagner D
ARTERIOSCL THROM VAS. 2012;32(8):1777-83.

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies
Fuchs T, Kremer Hovinga J, Schatzberg D, Wagner D, Lämmle B
BLOOD. 2012;120(6):1157-64.

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice
Thomas G, Carbo C, Curtis B, Martinod K, Mazo I, Schatzberg D, Cifuni S, Fuchs T, von Andrian U, Hartwig J, Aster R, Wagner D
BLOOD. 2012;119(26):6335-43.

T granules in human platelets function in TLR9 organization and signaling
Thon J, Peters C, Machlus K, Aslam R, Rowley J, Macleod H, Devine M, Fuchs T, Weyrich A, Semple J, Flaumenhaft R, Italiano J
J CELL BIOL. 2012;198(4):561-74.

von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models
Brill A, Fuchs T, Chauhan A, Yang J, De Meyer S, Köllnberger M, Wakefield T, Lämmle B, Massberg S, Wagner D
BLOOD. 2011;117(4):1400-7.

Histones induce rapid and profound thrombocytopenia in mice
Fuchs T, Bhandari A, Wagner D
BLOOD. 2011;118(13):3708-14.

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation
Hakkim A, Fuchs T, Martinez N, Hess S, Prinz H, Zychlinsky A, Waldmann H
NAT CHEM BIOL. 2011;7(2):75-7.

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity
Metzler K, Fuchs T, Nauseef W, Reumaux D, Roesler J, Schulze I, Wahn V, Papayannopoulos V, Zychlinsky A
BLOOD. 2011;117(3):953-9.

Extracellular DNA traps promote thrombosis
Fuchs T, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers D, Wrobleski S, Wakefield T, Hartwig J, Wagner D
P NATL ACAD SCI USA. 2010;107(36):15880-5.

Novel cell death program leads to neutrophil extracellular traps
Fuchs T, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, Weinrauch Y, Brinkmann V, Zychlinsky A
J CELL BIOL. 2007;176(2):231-41.

Chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency both yield strongly reduced dihydrorhodamine 123 test signals but can be easily discerned in routine testing for CGD
Mauch L, Lun A, O'Gorman M, Harris J, Schulze I, Zychlinsky A, Fuchs T, Oelschlägel U, Brenner S, Kutter D, Rösen-Wolff A, Roesler J
CLIN CHEM. 2007;53(5):890-6.

Letzte Aktualisierung aus dem FIS: 24.11.2024 - 03:45 Uhr