Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis
Gallwitz L, Bleibaum F, Voss M, Schweizer M, Spengler K, Winter D, Zöphel F, Müller S, Lichtenthaler S, Damme M, Saftig P
CELL MOL LIFE SCI. 2024;81(1):227.

Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo
Gui Y, Kim Y, Brenna S, Wilmes M, Zaghen G, Goulbourne C, Kuchenbecker-Pöls L, Siebels B, Voß H, Gocke A, Schlüter H, Schweizer M, Altmeppen H, Magnus T, Levy E, Puig B
CELL MOL LIFE SCI. 2024;81(1):224.

Functional inhibition of katanin affects synaptic plasticity
Lombino F, Schwarz J, Pechmann Y, Schweizer M, Jark R, Stange O, Glatzel M, Gee C, Hausrat T, Gromova K, Kneussel M
J NEUROSCI. 2024;44(13):.

Inefficient tissue immune response against MPXV in an immunocompromised mpox patient
Matschke J, Hartmann K, Pfefferle S, Wang Y, Valdes P, Thies E, Schweizer M, Lütgehetmann M, Schmiedel S, Bernreuther C, Boyden E, Glatzel M, Krasemann S
J MED VIROL. 2024;96(7):e29811.

PITX2 deficiency leads to atrial mitochondrial dysfunction
Reyat J, Sommerfeld L, O'Reilly M, Roth Cardoso V, Thiemann E, Khan A, O'Shea C, Harder S, Müller C, Barlow J, Stapley R, Chua W, Kabir S, Grech O, Hummel O, Hübner N, Kääb S, Mont L, Hatem S, Winters J, Zeemering S, Morgan N, Rayes J, Gehmlich K, Stoll M, Brand T, Schweizer M, Piasecki A, Schotten U, Gkoutos G, Lorenz K, Cuello F, Kirchhof P, Fabritz L
CARDIOVASC RES. 2024;120(15):1907-1923.

Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
Schroeter C, Nelke C, Stascheit F, Huntemann N, Preusse C, Dobelmann V, Theissen L, Pawlitzki M, Räuber S, Willison A, Vogelsang A, Marina A, Hartung H, Melzer N, Konen F, Skripuletz T, Hentschel A, König S, Schweizer M, Stühler K, Poschmann G, Roos A, Stenzel W, Meisel A, Meuth S, Ruck T
ACTA NEUROPATHOL. 2024;147(102):102.

Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling
Wirth S, Schlößer A, Beiersdorfer A, Schweizer M, Woo M, Friese M, Lohr C, Grochowska K
GLIA. 2024;72(8):1451-1468.

TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells
Wünkhaus D, Tang R, Nyame K, Laqtom N, Schweizer M, Scotto Rosato A, Krogsæter E, Wollnik C, Abu-Remaileh M, Grimm C, Hermey G, Kuhn R, Gruber-Schoffnegger D, Markmann S
SCI REP-UK. 2024;14(1):.

Inactivation of spermine synthase in mice causes osteopenia due to reduced osteoblast activity
Yorgan T, Zhu Y, Wiedemann P, Schöneck K, Pohl S, Schweizer M, Amling M, Barvencik F, Oheim R, Schinke T
J BONE MINER RES. 2024;39(11):1606-1620.

Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses
Andres-Alonso M, Borgmeyer M, Mirzapourdelavar H, Lormann J, Klein K, Schweizer M, Hoffmeister-Ullerich S, Oelschlegel A, Dityatev A, Kreutz M
CELL REP. 2023;42(7):.

The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
Gromova K, Thies E, Janiesch P, Lützenkirchen F, Zhu Y, Stajano D, Dürst C, Schweizer M, Konietzny A, Mikhaylova M, Gee C, Kneussel M
CELL REP. 2023;42(7):1-24.

Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism
Loos M, Klampe B, Schulze T, Yin X, Theofilatos K, Ulmer B, Schulz C, Behrens C, van Bergen T, Adami E, Maatz H, Schweizer M, Brodesser S, Skryabin B, Rozhdestvensky T, Bodbin S, Stathopoulou K, Christ T, Denning C, Hübner N, Mayr M, Cuello F, Eschenhagen T, Hansen A
STEM CELL REP. 2023;18(11):2123-2137.

Short-term dietary changes can result in mucosal and systemic immune depression
Siracusa F, Schaltenberg N, Kumar Y, Lesker T, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks B, Bönisch F, Fischer A, Scognamiglio P, Pauly M, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker H, Kretz O, Guse A, Izbicki J, Lassen K, Strowig T, Schweizer M, Villablanca E, Elinav E, Huber S, Heeren J, Gagliani N
NAT IMMUNOL. 2023;24(9):1473-1486.

Tetraspanin 15 depletion impairs extracellular vesicle docking at target neurons
Stajano D, Lombino F, Schweizer M, Glatzel M, Saftig P, Gromova K, Kneussel M
Journal of Extracellular Biology. 2023;2(9):e113.

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart
Bräuninger H, Stoffers B, Fitzek A, Meißner K, Aleshcheva G, Schweizer M, Weimann J, Rotter B, Warnke S, Edler C, Braun F, Roedl K, Scherschel K, Escher F, Kluge S, Huber T, Ondruschka B, Schultheiss H, Kirchhof P, Blankenberg S, Püschel K, Westermann D, Lindner D
CARDIOVASC RES. 2022;118(2):542-555.

Monoallelic loss of the F-actin-binding protein radixin facilitates startle reactivity and pre-pulse inhibition in mice
Hausrat T, Vogl C, Neef J, Schweizer M, Yee B, Strenzke N, Kneussel M
FRONT CELL DEV BIOL. 2022;10:.

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
Krasemann S, Haferkamp U, Pfefferle S, Woo M, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau J, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König E, Bodem J, Franzenburg S, Franke A, Moese S, Müller F, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese M, Glatzel M, Pless O
STEM CELL REP. 2022;17(2):307-320.

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection
Richards C, Jabs S, Qiao W, Varanese L, Schweizer M, Mosen P, Riley N, Klüssendorf M, Zengel J, Flynn R, Rustagi A, Widen J, Peters C, Ooi Y, Xie X, Shi P, Bartenschlager R, Puschnik A, Bogyo M, Bertozzi C, Blish C, Winter D, Nagamine C, Braulke T, Carette J
SCIENCE. 2022;378(6615):.

Endogenous tagging reveals a mid-Golgi localization of the glycosyltransferase-cleaving intramembrane protease SPPL3
Truberg J, Hobohm L, Jochimsen A, Desel C, Schweizer M, Voss M
BBA-MOL CELL RES. 2022;1869(11):.

Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Borgmeyer M, Coman C, Has C, Schött H, Li T, Westhoff P, Cheung Y, Hoffmann N, Yuanxiang P, Behnisch T, Gomes G, Dumenieu M, Schweizer M, Chocholoušková M, Holčapek M, Mikhaylova M, Kreutz M, Ahrends R
CELL REP. 2021;37(1):109797.

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation
Cuello F, Knaust A, Saleem U, Loos M, Raabe J, Mosqueira D, Laufer S, Schweizer M, van der Kraak P, Flenner F, Ulmer B, Braren I, Yin X, Theofilatos K, Ruiz-Orera J, Patone G, Klampe B, Schulze T, Piasecki A, Pinto Y, Vink A, Hübner N, Harding S, Mayr M, Denning C, Eschenhagen T, Hansen A
EMBO MOL MED. 2021;13(6):e13074.

Pathogenic variants in GNPTAB and GNPTG encoding distinct subunits of GlcNAc-1-phosphotransferase differentially impact bone resorption in patients with mucolipidosis type II and III
Di Lorenzo G, Westermann L, Schinke T, Stürznickel J, Ludwig N, Ammer L, Baranowsky A, Ahmadi S, Pourbarkhordariesfandabadi E, Breyer S, Board T, Foster A, Mercer J, Tylee K, Velho R, Schweizer M, Renné T, Braulke T, Randon D, Sperb-Ludwig F, de Camargo Pinto L, Moreno C, Cavalcanti D, Amling M, Kutsche K, Winter D, Muschol N, Schwartz I, Rolvien T, Danyukova T, Schinke T, Pohl S
GENET MED. 2021;23(12):2369-2377.

Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation
Hendrickx G, Fischer V, Liedert A, von Kroge S, Haffner-Luntzer M, Brylka L, Pawlus E, Schweizer M, Yorgan T, Baranowsky A, Rolvien T, Neven M, Schumacher U, Beech D, Amling M, Ignatius A, Schinke T
J BONE MINER RES. 2021;36(2):369-384.

Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome
Kement D, Reumann R, Schostak K, Voß H, Douceau S, Dottermusch M, Schweizer M, Schlüter H, Vivien D, Glatzel M, Galliciotti G
FRONT NEUROANAT. 2021;15:627896.

Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies
Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bär J, Shrivastava A, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, Mazzola F, Varani L, Thapa S, Gilch S, Schätzl H, Harris D, Triller A, Mikhaylova M, Aguzzi A, Altmeppen H, Glatzel M
SCI ADV. 2021;7(48):eabj1826.

Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
Mailer R, Allende M, Heestermans M, Schweizer M, Deppermann C, Frye M, Pula G, Odeberg J, Gelderblom M, Rose-John S, Sickmann A, Blankenberg S, Huber T, Kubisch C, Maas C, Gambaryan S, Firsov D, Stavrou E, Butler L, Renné T
BLOOD. 2021;137(10):1392-1405.

Wnt1 Promotes Cementum and Alveolar Bone Growth in a Time-Dependent Manner
Nottmeier C, Liao N, Simon A, Decker M, Luther J, Schweizer M, Yorgan T, Kaucka M, Bockamp E, Kahl-Nieke B, Amling M, Schinke T, Petersen J, Koehne T
J DENT RES. 2021;100(13):1501-1509.

Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue
Rhoden A, Friedrich F, Brandt T, Raabe J, Schweizer M, Meisterknecht J, Wittig I, Ulmer B, Klampe B, Uebeler J, Piasecki A, Lorenz K, Eschenhagen T, Hansen A, Cuello F
REDOX BIOL. 2021;41:101951.

TFEB-deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality
Sass F, Schlein C, Jaeckstein M, Pertzborn P, Schweizer M, Schinke T, Ballabio A, Scheja L, Heeren J, Fischer A
MOL METAB. 2021;47:101173.

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
Schlein C, Fischer A, Sass F, Worthmann A, Tödter K, Jaeckstein M, Behrens J, Lynes M, Kiebish M, Narain N, Bussberg V, Jespersen N, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng Y, Heeren J, Scheja L
CELL REP. 2021;34(2):108624.

The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV
Vollersen N, Zhao W, Rolvien T, Lange F, Schmidt F, Sonntag S, Shmerling D, von Kroge S, Stockhausen K, Sharaf A, Schweizer M, Karsak M, Busse B, Bockamp E, Semler O, Amling M, Oheim R, Schinke T, Yorgan T
BONE RES. 2021;9(1):48.

Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis
Arnold J, Schattschneider J, Blechner C, Krisp C, Schlüter H, Schweizer M, Nalaskowski M, Oliveira-Ferrer L, Windhorst S
J EXP CLIN CANC RES. 2020;39(1):205.

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
Feyen D, McKeithan W, Bruyneel A, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen R, Ginsburg K, Lam C, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya P, Behrens C, Ranjbarvaziri S, Maas R, Greenhaw M, Bernstein D, Wu J, Bers D, Eschenhagen T, Metallo C, Mercola M
CELL REP. 2020;32(3):107925.

Enzyme replacement therapy in mice lacking arylsulfatase B targets bone remodeling cells, but not chondrocytes
Hendrickx G, Danyukova T, Baranowsky A, Rolvien T, Angermann A, Schweizer M, Keller J, Schröder J, Meyer-Schwesinger C, Muschol N, Paganini C, Rossi A, Amling M, Pohl S, Schinke T
HUM MOL GENET. 2020;29(5):803-816.

Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin
Hermann M, Reumann R, Schostak K, Kement D, Gelderblom M, Bernreuther C, Frischknecht R, Schipanski A, Marik S, Krasemann S, Sepulveda-Falla D, Schweizer M, Magnus T, Glatzel M, Galliciotti G
MOL CELL NEUROSCI. 2020;102:103420.

Cardiac SARS-CoV-2 infection is associated with distinct transcriptomic changes within the heart
Lindner D, Bräuninger H, Stoffers B, Fitzek A, Meißner K, Aleshcheva G, Schweizer M, Weimann J, Rotter B, Warnke S, Edler C, Braun F, Roedl K, Scherschel K, Escher F, Kluge S, Huber T, Ondruschka B, Heinz-Peter-Schultheiss , Kirchhof P, Blankenberg S, Püschel K, Westermann D
medRxiv. 2020;2020.12.19.20248542.

Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits
Lopes A, Hausrat T, Heisler F, Gromova K, Lombino F, Fischer T, Ruschkies L, Breiden P, Thies E, Hermans-Borgmeyer I, Schweizer M, Schwarz J, Lohr C, Kneussel M
PLOS BIOL. 2020;18(8):e3000820.

An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility
Madsen A, Höppner G, Krause J, Hirt M, Laufer S, Schweizer M, Tan W, Mosqueira D, Anene-Nzelu C, Lim I, Foo R, Eschenhagen T, Stenzig J
CIRCULATION. 2020;142(16):1562-1578.

Nonspecific Expression in Limited Excitatory Cell Populations in Interneuron-Targeting Cre-driver Lines Can Have Large Functional Effects
Müller-Komorowska D, Opitz T, Elzoheiry S, Schweizer M, Ambrad Giovannetti E, Beck H
FRONT NEURAL CIRCUIT. 2020;14:16.

Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma
Westermann L, Fleischhauer L, Vogel J, Jenei-Lanzl Z, Floriano Ludwig N, Schau L, Morellini F, Baranowsky A, Yorgan T, Di Lorenzo G, Schweizer M, de Souza Pinheiro B, Guarany N, Sperb-Ludwig F, Visioli F, Oliveira Silva T, Soul J, Hendrickx G, Wiegert J, Schwartz I, Clausen-Schaumann H, Zaucke F, Schinke T, Pohl S, Danyukova T
DIS MODEL MECH. 2020;13(11):.

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
Andres-Alonso M, Ammar M, Butnaru I, Gomes G, Acuña Sanhueza G, Raman R, Yuanxiang P, Borgmeyer M, Lopez-Rojas J, Raza S, Brice N, Hausrat T, Macharadze T, Diaz-Gonzalez S, Carlton M, Failla A, Stork O, Schweizer M, Gundelfinger E, Kneussel M, Spilker C, Karpova A, Kreutz M
NAT COMMUN. 2019;10(1):5448.

Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks
Reinicke A, Laban K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch P, Duncan K, Saftig P, Rinschen M, Morellini F, Meyer-Schwesinger C
P NATL ACAD SCI USA. 2019;116(16):7963-7972.

Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling
Richter M, Murtaza N, Scharrenberg R, White S, Johanns O, Walker S, Yuen R, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch J, Hanganu-Opatz I, Morellini F, Scherer S, Singh K, Calderon de Anda F
MOL PSYCHIATR. 2019;24(9):1329-1350.

Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization
Roesler M, Lombino F, Freitag S, Schweizer M, Hermans-Borgmeyer I, Schwarz J, Kneussel M, Wagner W
FRONT CELL NEUROSCI. 2019;13:330.

Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking
Schmidtke C, Tiede S, Thelen M, Käkelä R, Jabs S, Makrypidi G, Sylvester M, Schweizer M, Braren I, Brocke-Ahmadinejad N, Cotman S, Schulz A, Gieselmann V, Braulke T
J BIOL CHEM. 2019;294(24):9592-9604.

Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice
Schob C, Morellini F, Ohana O, Bakota L, Hrynchak M, Brandt R, Brockmann M, Cichon N, Hartung H, Hanganu-Opatz I, Kraus V, Scharf S, Herrmans-Borgmeyer I, Schweizer M, Kuhl D, Wöhr M, Vörckel K, Calzada-Wack J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Garner C, Kreienkamp H, Kindler S
TRANSL PSYCHIAT. 2019;9(1):7.

Maintenance of cell type-specific connectivity and circuit function requires Tao kinase
Tenedini F, Sáez González M, Hu C, Pedersen L, Petruzzi M, Spitzweck B, Wang D, Richter M, Petersen M, Szpotowicz E, Schweizer M, Sigrist S, Calderon de Anda F, Soba P
NAT COMMUN. 2019;10(1):3506.

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression
Wagner W, Lippmann K, Heisler F, Gromova K, Lombino F, Roesler M, Pechmann Y, Hornig S, Schweizer M, Polo S, Schwarz J, Eilers J, Kneussel M
CELL REP. 2019;28(1):11-20.e9.

Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells
Di Lorenzo G, Velho R, Winter D, Thelen M, Ahmadi S, Schweizer M, De Pace R, Cornils K, Yorgan T, Grüb S, Hermans-Borgmeyer I, Schinke T, Müller-Loennies S, Braulke T, Pohl S
MOL CELL PROTEOMICS. 2018;17(8):1612-1626.

Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes
Gonzalez A, Schweizer M, Jagdmann S, Bernreuther C, Reinheckel T, Saftig P, Damme M
CELL REP. 2018;22(4):1040-1053.

Muskelin Coordinates PrP Lysosome versus Exosome Targeting and Impacts Prion Disease Progression
Heisler F, Pechmann Y, Wieser I, Altmeppen H, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M
NEURON. 2018;99(6):1155-1169.e9.

Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand
Luther J, Yorgan T, Rolvien T, Ulsamer L, Koehne T, Liao N, Keller D, Vollersen N, Teufel S, Neven M, Peters S, Schweizer M, Trumpp A, Rosigkeit S, Bockamp E, Mundlos S, Kornak U, Oheim R, Amling M, Schinke T, David J
SCI TRANSL MED. 2018;10(466):eaau7137.

Visualization of translocons in Yersinia type III protein secretion machines during host cell infection
Nauth T, Huschka F, Schweizer M, Bosse J, Diepold A, Failla A, Steffen A, Stradal T, Wolters M, Aepfelbacher M
PLOS PATHOG. 2018;14(12):e1007527.

The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover
Pohl S, Angermann A, Jeschke A, Hendrickx G, Yorgan T, Makrypidi-Fraune G, Steigert A, Kuehn S, Rolvien T, Schweizer M, Koehne T, Neven M, Winter O, Velho R, Albers J, Streichert T, Pestka J, Baldauf C, Breyer S, Stuecker R, Muschol N, Cox T, Saftig P, Paganini C, Rossi A, Amling M, Braulke T, Schinke T
J BONE MINER RES. 2018;33(12):2186-2201.

Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity
Schmiesing J, Storch S, Dörfler A, Schweizer M, Makrypidi-Fraune G, Thelen M, Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly W, Braulke T
CELL REP. 2018;24(11):2946-2956.

In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15
Seipold L, Altmeppen H, Koudelka T, Tholey A, Kasparek P, Sedlacek R, Schweizer M, Bär J, Mikhaylova M, Glatzel M, Saftig P
CELL MOL LIFE SCI. 2018;75(17):3251-3267.

Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction
Grochowska K, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth H, Kreutz M
EMBO REP. 2017;18(6):962-981.

Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior
Hu C, Petersen M, Hoyer N, Spitzweck B, Tenedini F, Wang D, Gruschka A, Burchardt L, Szpotowicz E, Schweizer M, Guntur A, Yang C, Soba P
NAT NEUROSCI. 2017;20(8):1085-1095.

Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II
Markmann S, Krambeck S, Hughes C, Mirzaian M, Aerts J, Saftig P, Schweizer M, Vissers J, Braulke T, Damme M
MOL CELL PROTEOMICS. 2017;16(3):438-450.

The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone
Milovanovic P, Zimmermann E, vom Scheidt A, Hoffmann B, Sarau G, Yorgan T, Schweizer M, Amling M, Christiansen S, Busse B
SMALL. 2017;13(3):n/a-n/a.

Disease-causing mutations affecting surface residues of mitochondrial glutaryl-CoA dehydrogenase impair stability, heteromeric complex formation, and mitochondria architecture
Schmiesing J, Lohmöller B, Schweizer M, Tidow H, Gersting S, Muntau A, Braulke T, Mühlhausen C
HUM MOL GENET. 2017;26(3):538-551.

The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments
Schneppenheim J, Loock A, Hüttl S, Schweizer M, Lüllmann-Rauch R, Oberg H, Arnold P, Lehmann C, Dudziak D, Kabelitz D, Lucius R, Lennon-Duménil A, Saftig P, Schröder B
J IMMUNOL. 2017;199(1):172-185.

Proteomics insights into infantile neuronal ceroid lipofuscinosis (CLN1) point to the involvement of cilia pathology in the disease
Segal-Salto M, Hansson K, Sapir T, Kaplan A, Levy T, Schweizer M, Frotscher M, James P, Reiner O
HUM MOL GENET. 2017;26(9):1678.

Site-1 protease and lysosomal homeostasis
Velho R, De Pace R, Klünder S, Di Lorenzo G, Schweizer M, Braulke T, Pohl S
BBA-MOL CELL RES. 2017;1864(11 Pt B):2162-2168.

Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice
Abramowski P, Krasemann S, Ernst T, Lange C, Ittrich H, Schweizer M, Zander A, Martin R, Fehse B
STEM CELLS DEV. 2016;25(15):1134-48.

Lysosomal dysfunction and impaired autophagy in a novel mouse model deficient for the lysosomal membrane protein Cln7
Brandenstein L, Schweizer M, Sedlacik J, Fiehler J, Storch S
HUM MOL GENET. 2016;25(4):777-91.

Rsk2, the kinase in Coffin-Lowry syndrome controls cementum formation
Koehne T, Jeschke A, Petermann F, Seitz S, Neven M, Peters S, Luther J, Schweizer M, Schinke T, Kahl-Nieke B, Amling M, David J
J DENT RES. 2016;95(7):752-760.

Mannose 6-phosphate-dependent targeting of lysosomal enzymes is required for normal craniofacial and dental development
Koehne T, Markmann S, Schweizer M, Muschol N, Friedrich R, Hagel C, Glatzel M, Kahl-Nieke B, Amling M, Schinke T, Braulke T
BBA-MOL BASIS DIS. 2016;1862(9):1570–1580.

Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines
Köster J, Leggewie B, Blechner C, Brandt N, Fester L, Rune G, Schweizer M, Kindler S, Windhorst S
CELL SIGNAL. 2016;28(1):83-90.

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
Kuhn P, Colombo A, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler S
ELIFE. 2016;5:e12748.

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory
Muhia M, Thies E, Labonté D, Ghiretti A, Gromova K, Xompero F, Lappe-Siefke C, Hermans-Borgmeyer I, Kuhl D, Schweizer M, Ohana O, Schwarz J, Holzbaur E, Kneussel M
CELL REP. 2016;15(5):968-77.

Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical fot B Cell Receptor Signaling in Transitional B Cells.
Hüttl S, Kläsener K, Schweizer M, Schneppenheim J, Oberg H, Kabelitz D, Reth M, Saftig P, Schröder B
J IMMUNOL. 2015;195 (4):1548-1563.

Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells
Jeschke A, Catala-Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, Wintges K, Marshall R, Mautner A, Duchstein L, Otto B, Horst A, Amling M, Kreienkamp H, Schinke T
J IMMUNOL. 2015;195(8):3675-84.

Impaired bone remodeling and its correction by combination therapy in a mouse model of mucopolysaccharidosis-I
Kühn S, Koehne T, Cornils K, Markmann S, Riedel C, Pestka J, Schweizer M, Baldauf C, Yorgan T, Krause M, Keller J, Neven M, Breyer S, Stücker R, Muschol N, Busse B, Braulke T, Fehse B, Amling M, Schinke T
HUM MOL GENET. 2015;24(24):7075-7086.

Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting
Markmann S, Thelen M, Cornils K, Schweizer M, Brocke-Ahmadinejad N, Willnow T, Heeren J, Gieselmann V, Braulke T, Kollmann K
TRAFFIC. 2015.

Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions
Otomo T, Schweizer M, Kollmann K, Schumacher V, Muschol N, Tolosa E, Mittrücker H, Braulke T
J CELL BIOL. 2015;208(2):171-80.

Biological Relevance and Therapeutic Potential of the Hypusine Modification System
Pallmann N, Braig M, Sievert H, Preukschas M, Hermans-Borgmeyer I, Schweizer M, Nagel C, Neumann M, Wild P, Haralambieva E, Hagel C, Bokemeyer C, Hauber J, Balabanov S
J BIOL CHEM. 2015;290(30):18343-18360.

LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease
Rothaug M, Stroobants S, Schweizer M, Peters J, Zunke F, Allerding M, D Hooge R, Saftig P, Blanz J
ACTA NEUROPATHOL COM. 2015;3(1):6.

A spastic paraplegia mouse model reveals REEP1-dependent ER shaping
Beetz C, Koch N, Khundadze M, Zimmer G, Nietzsche S, Hertel N, Huebner A, Mumtaz R, Schweizer M, Dirren E, Karle K, Irintchev A, Alvarez V, Redies C, Westermann M, Kurth I, Deufel T, Kessels M, Qualmann B, Hübner C
J CLIN INVEST. 2014;124(6):2809.

Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease
Damme M, Brandenstein L, Fehr S, Jankowiak W, Bartsch U, Schweizer M, Hermans-Borgmeyer I, Storch S
NEUROBIOL DIS. 2014;65:12-24.

GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites
Heisler F, Lee H, Gromova K, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M
P NATL ACAD SCI USA. 2014;111(13):5030-5.

α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders
Kurt S, Zuccotti A, Pirone A, Rüttiger L, Pilz P, Brown D, Franz C, Schweizer M, Rust M, Rübsamen R, Friauf E, Knipper M, Engel J
J NEUROSCI. 2014;34(2):434-45.

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
Rothaug M, Zunke F, Mazzulli J, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn W, Gaspar P, Aerts J, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J
P NATL ACAD SCI USA. 2014;111(43):15573-8.

A novel mouse model for inhibition of DOHH mediated hypusine modification reveals crucial function for embryonic development, proliferation and oncogenic transformation
Sievert H, Pällmann N, Miller K, Hermans-Borgmeyer I, Venz S, Sendoel A, Preukschas M, Schweizer M, Böttcher S, Janiesch P, Streichert T, Walther R, Hengartner M, Manz M, Brümmendorf T, Bokemeyer C, Balabanov M, Hauber J, Duncan K, Balabanov S
DIS MODEL MECH. 2014.

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma
Grapp M, Wrede A, Schweizer M, Hüwel S, Galla H, Snaidero N, Simons M, Bückers J, Low P, Urlaub H, Gärtner J, Steinfeld R
NAT COMMUN. 2013;4:2123.

Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate
Helmis C, Blechner C, Lin H, Schweizer M, Mayr G, Nielsen P, Windhorst S
BIOSCIENCE REP. 2013;33(5):.

Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II
Kollmann K, Pestka J, Kühn S, Schöne E, Schweizer M, Karkmann K, Otomo T, Catala-Lehnen P, Failla A, Marshall R, Krause M, Santer R, Amling M, Braulke T, Schinke T
EMBO MOL MED. 2013;5(12):1871-86.

Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P
J NEUROSCI. 2013;33(32):12915-28, 12928a.

A novel interaction between aging and ER overload in a protein conformational dementia
Schipanski A, Lange S, Segref A, Gutschmidt A, Lomas D, Miranda E, Schweizer M, Hoppe T, Glatzel M
GENETICS. 2013;193(3):865-76.

Ultrastructural analysis of neuronal and non-neuronal lysosomal storage in mucolipidosis type II knock-in mice
Schweizer M, Markmann S, Braulke T, Kollmann K
ULTRASTRUCT PATHOL. 2013;37(5):366-72.

Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1
Thies B, Meyer-Schwesinger C, Lamp J, Schweizer M, Koeller D, Ullrich K, Braulke T, Mühlhausen C
BBA-MOL BASIS DIS. 2013;1832(10):1463-72.

Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5)
Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T
J BONE MINER RES. 2013;28(10):2070-80.

The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons
Zivraj K, Rehbein M, Ölschläger-Schütt J, Schob C, Falley K, Buck F, Schweizer M, Schepis A, Kremmer E, Richter D, Kreienkamp H, Kindler S
J NEUROCHEM. 2013;124(5):670-84.

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Kollmann K, Damme M, Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert A, Pohl S, Lübke T, Michalski J, Käkelä R, Walkley S, Braulke T
BRAIN. 2012;135(Pt 9):2661-2675.

M-phase phosphoprotein 11 is a highly immunogenic tumor antigen in patients with acute myeloid leukemia.
Siegel S, Wirth S, Schweizer M, Schmitz N, Zeis M
ACTA HAEMATOL-BASEL. 2012;127(4):193-197.

Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis.
Thelen M, Damme M, Daμμe M, Schweizer M, Hagel C, Wong A, Cooper J, Braulke T, Galliciotti G
PLOS ONE. 2012;7(4):35493.

High expression of disease-related Cln6 in the cerebral cortex, purkinje cells, dentate gyrus, and hippocampal ca1 neurons.
Thelen M, Fehr S, Schweizer M, Braulke T, Galliciotti G
J NEUROSCI RES. 2012;90(3):568-574.

Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue.
Hein S, Müller V, Köhler N, Wikman H, Krenkel S, Streichert T, Schweizer M, Riethdorf S, Assmann V, Henningsen M, Beck K, Issa R, Jänicke F, Pantel K, Milde-Langosch K
BREAST CANCER RES TR. 2011;129(2):347-360.

Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.
Heisler F, Löbrich S, Pechmann Y, Maier N, Zivkovic A, Tokito M, Hausrat T, Schweizer M, Bähring R, Holzbaur E, Schmitz D, Kneussel M
NEURON. 2011;70(1):66-81.

A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism.
Marschner K, Kollmann K, Schweizer M, Braulke T, Pohl S
SCIENCE. 2011;333(6038):87-90.

Impaired stria vascularis integrity upon loss of E-cadherin in basal cells.
Trowe M, Maier H, Petry M, Schweizer M, Schuster-Gossler K, Kispert A
DEV BIOL. 2011;359(1):95-107.

Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes.
Wang S, Cesca F, Loers G, Schweizer M, Buck F, Benfenati F, Schachner M, Kleene R
J NEUROSCI. 2011;31(20):7275-7290.

Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Schapitz I, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel S, Wallace K, Stempel A, Buck F, Grant S, Schweizer M, Schmitz D, Schwarz J, Holzbaur E, Kneussel M
J NEUROSCI. 2010;30(38):12733-12744.

Erg K+ currents modulate excitability in mouse mitral/tufted neurons.
Hirdes W, Napp N, Wulfsen I, Schweizer M, Schwarz J, Bauer C
PFLUG ARCH EUR J PHY. 2009;459(1):55-70.

The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.
Lappe-Siefke C, Löbrich S, Hevers W, Waidmann O, Schweizer M, Fehr S, Fritschy J, Dikic I, Eilers J, Wilson S, Kneussel M
PLOS GENET. 2009;5(9):1000631.

The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.
Sawallisch C, Berhörster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S, Kindler S, Morellini F, Schweizer M, Boeckers T, Korte M, Scita G, Kreienkamp H
J BIOL CHEM. 2009;284(14):9225-9236.

Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7.
Wartosch L, Fuhrmann J, Schweizer M, Stauber T, Jentsch T
FASEB J. 2009;23(12):4056-4068.

Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability.
Jacobs S, Ruusuvuori E, Sipilä S, Haapanen A, Damkier H, Kurth I, Hentschke M, Schweizer M, Rudhard Y, Laatikainen L, Tyynelä J, Praetorius J, Voipio J, Hübner C
P NATL ACAD SCI USA. 2008;105(1):311-316.

Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes.
Trowe M, Maier H, Schweizer M, Kispert A
DEVELOPMENT. 2008;135(9):1725-1734.

Leukoencephalopathy upon disruption of the chloride channel ClC-2.
Blanz J, Schweizer M, Auberson M, Maier H, Münscher A, Hübner C, Jentsch T
J NEUROSCI. 2007;27(24):6581-6589.

Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells.
Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K
J NEUROCHEM. 2007;103(1):259-275.

Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function.
Kurth I, Thompson D, Rüther K, Feathers K, Chrispell J, Schroth J, McHenry C, Schweizer M, Skosyrski S, Gal A, Hübner C
MOL CELL BIOL. 2007;27(4):1370-1379.

Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro.
Loges S, Butzal M, Wellbrock J, Schweizer M, Fischer U, Bokemeyer C, Hossfeld D, Schuch G, Fiedler W
BIOCHEM BIOPH RES CO. 2007;357(4):1016-1020.

Letzte Aktualisierung aus dem FIS: 23.12.2024 - 03:00 Uhr