2024

Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
Hartmann J, Cardoso M, Talarico M, Kenney D, Leone M, Reese D, Turcinovic J, O'Connell A, Gertje H, Marino C, Ojeda P, De Paula E, Orsi F, Velloso L, Cafiero T, Connor J, Ploss A, Hoelzemer A, Carrington M, Barczak A, Crossland N, Douam F, Boucau J, Garcia-Beltran W
CELL. 2024;187(10):2393-2410.e14.

HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells
Zecher B, Ellinghaus D, Schloer S, Niehrs A, Padoan B, Baumdick M, Yuki Y, Martin M, Glow D, Schröder-Schwarz J, Niersch J, Brias S, Müller L, Habermann R, Kretschmer P, Früh T, Dänekas J, Wehmeyer M, Poch T, Sebode M, , Ellinghaus E, Degenhardt F, Körner C, Hoelzemer A, Fehse B, Oldhafer K, Schumacher U, Sauter G, Carrington M, Franke A, Bunders M, Schramm C, Altfeld M
GUT. 2024;73(2):325-337.

2023

HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses
Lin Z, Bashirova A, Viard M, Garner L, Quastel M, Beiersdorfer M, Kasprzak W, Akdag M, Yuki Y, Ojeda P, Das S, Andresson T, Naranbhai V, Horowitz A, McMichael A, Hoelzemer A, Gillespie G, Garcia-Beltran W, Carrington M
NAT IMMUNOL. 2023;24(7):1087-1097.

2022

HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells
Fittje P, Hölzemer A, Garcia-Beltran W, Vollmers S, Niehrs A, Hagemann K, Martrus G, Körner C, Kirchhoff F, Sauter D, Altfeld M
PLOS PATHOG. 2022;18(6):.

Prevalence and risk factors of undiagnosed diabetes mellitus among gastroenterological patients: a HbA1c-based single center experience – Prevalence of undiagnosed diabetes in gastroenterological patients
Fründt T, Schröder N, Hölzemer A, Pinnschmidt H, de Heer J, Behrends B, Renne T, Lautenbach A, Lohse A, Schrader J
Z GASTROENTEROL. 2022;60(9):1306-1313.

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
Garcia-Beltran W, St. Denis K, Hoelzemer A, Lam E, Nitido A, Sheehan M, Berrios C, Ofoman O, Chang C, Hauser B, Feldman J, Roederer A, Gregory D, Poznansky M, Schmidt A, Iafrate A, Naranbhai V, Balazs A
CELL. 2022;185(3):457-466.e4.

Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells
Höfle J, Trenkner T, Kleist N, Schwane V, Vollmers S, Barcelona B, Niehrs A, Fittje P, Huynh-Tran V, Sauter J, Schmidt A, Peine S, Hoelzemer A, Richert L, Altfeld M, Körner C
EMBO REP. 2022;23(8):.

NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses
Mensching L, Hölzemer A
FRONT IMMUNOL. 2022;13:.

Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C
Vollmers S, Lobermeyer A, Niehrs A, Fittje P, Indenbirken D, Nakel J, Virdi S, Brias S, Trenkner T, Sauer G, Peine S, Behrens G, Lehmann C, Meurer A, Pauli R, Postel N, Roider J, Scholten S, Spinner C, Stephan C, Wolf E, Wyen C, Richert L, Norman P, Sauter J, Schmidt A, Hölzemer A, Altfeld M, Körner C
FRONT IMMUNOL. 2022;13:.

2021

Clinical presentation and disease course of 37 consecutive cases of progressive multifocal leukoencephalopathy (PML) at a German tertiary-care hospital: a retrospective observational study
Graf L, Rosenkranz S, Hölzemer A, Hagel C, Goebell E, Jordan S, Friese M, Addo M, Schulze zur Wiesch J, Beisel C
FRONT NEUROL. 2021;12:632535.

KIR3DS1 directs NK cell-mediated protection against human adenovirus infections
Jung J, Ching W, Baumdick M, Hofmann-Sieber H, Bosse J, Koyro T, Möller K, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen S, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans C, Altfeld M, Belderbos M, Dobner T, Bunders M
SCI IMMUNOL. 2021;6(63):.

A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors
Klein K, Hölzemer A, Wang T, Kim T, Dugan H, Jost S, Altfeld M, Garcia-Beltran W
FRONT IMMUNOL. 2021;12:.

Upregulation of HLA-F expression by BK polyomavirus infection induces immune recognition by KIR3DS1-positive natural killer cells
Koyro T, Kraus E, Lunemann S, Hölzemer A, Wulf S, Jung J, Fittje P, Henseling F, Körner C, Huber T, Grundhoff A, Wiech T, Panzer U, Fischer N, Altfeld M
KIDNEY INT. 2021;99(5):1140-1148.

2019

A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44
Niehrs A, Garcia-Beltran W, Norman P, Watson G, Hölzemer A, Chapel A, Richert L, Pommerening-Röser A, Körner C, Ozawa M, Martrus G, Rossjohn J, Lee J, Berry R, Carrington M, Altfeld M
NAT IMMUNOL. 2019;20(9):1129-1137.

Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression
van Stigt Thans T, Akko J, Niehrs A, Garcia-Beltran W, Richert L, Stürzel C, Ford C, Li H, Ochsenbauer C, Kappes J, Hahn B, Kirchhoff F, Martrus G, Sauter D, Altfeld M, Hölzemer A
J VIROL. 2019;93(20):.

2018

HbA1c-basiertes Screening zur Erfassung eines unerkannten Diabetes mellitus bei gastroenterologischen Patienten in einer Klinik der Maximalversorgung
Fründt T, Schröder N, Pinnschmidt H, Hölzemer A, Heer J, Lohse A, Schrader J
Z GASTROENTEROL. 2018;56(08):e388-e389.

Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture
Lunemann S, Schöbel A, Kah J, Fittje P, Hölzemer A, Langeneckert A, Hess L, Poch T, Martrus G, Garcia-Beltran W, Körner C, Ziegler A, Richert L, Oldhafer K, Schulze Zur Wiesch J, Schramm C, Dandri M, Herker E, Altfeld M
GASTROENTEROLOGY. 2018;155(5):1366-1371.

2017

Peptide-specific engagement of the activating NK cell receptor KIR2DS1
Chapel A, Garcia-Beltran W, Hölzemer A, Ziegler M, Lunemann S, Martrus G, Altfeld M
SCI REP-UK. 2017;7(1):2414.

Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors
Dulberger C, McMurtrey C, Hölzemer A, Neu K, Liu V, Steinbach A, Garcia-Beltran W, Sulak M, Jabri B, Lynch V, Altfeld M, Hildebrand W, Adams E
IMMUNITY. 2017;46(6):1018-1029.e7.

Natural Killer Cell Interactions with Classical and Non-Classical Human Leukocyte Antigen Class I in HIV-1 Infection
Hölzemer A, Garcia-Beltran W, Altfeld M
FRONT IMMUNOL. 2017;8:1496.

HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells
Körner C, Simoneau C, Schommers P, Granoff M, Ziegler M, Hölzemer A, Lunemann S, Chukwukelu J, Corleis B, Naranbhai V, Kwon D, Scully E, Jost S, Kirchhoff F, Carrington M, Altfeld M
CELL HOST MICROBE. 2017;22(1):111-119.e4.

2016

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1
Garcia-Beltran W, Hölzemer A, Martrus G, Chung A, Pacheco Y, Simoneau C, Rucevic M, Lamothe-Molina P, Pertel T, Kim T, Dugan H, Alter G, Dechanet-Merville J, Jost S, Carrington M, Altfeld M
NAT IMMUNOL. 2016;17(9):1067-74.

Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C∗03:04 and modulate NK cell function
Lunemann S, Martrus G, Hölzemer A, Chapel A, Ziegler M, Körner C, Garcia Beltran W, Carrington M, Wedemeyer H, Altfeld M
J HEPATOL. 2016;65(2):252-8.

2015

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
Hölzemer A, Thobakgale C, Jimenez Cruz C, Garcia Beltran W, van Teijlingen N, Mann J, Jaggernath M, Chung A, Schafer J, Evans D, Alter G, Walker B, Goulder P, Carrington M, Hartmann P, Pertel T, Zhou R, Ndung'u T, Altfeld M
PLOS MED. 2015;12(11):e1001900.

Letzte Aktualisierung aus dem FIS: 23.12.2024 - 23:33 Uhr