2024

Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway
Ehm P, Horn S, Hoffer K, Kriegs M, Horn M, Giehler S, Nalaskowski M, Rehbach C, Horstmann M, Jücker M
CELL COMMUN SIGNAL. 2024;22(1):360.

K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3
Geißert R, Lammert A, Wirth S, Hönig R, Lohfink D, Unger M, Pek D, Schlüter K, Scheftschik T, Smit D, Jücker M, Menke A, Giehl K
CELL COMMUN SIGNAL. 2024;22(1):85.

Pronucleotide Probes Reveal a Diverging Specificity for AMPylation vs UMPylation of Human and Bacterial Nucleotide Transferases
Mostert D, Bubeneck W, Rauh T, Kielkowski P, Itzen A, Jung K, Sieber S
BIOCHEMISTRY-US. 2024;63(5):651-659.

Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer Cells by Controlling Microtubule Dynamics
Muhs S, Paraschiakos T, Schäfer P, Joosse S, Windhorst S
CELLS-BASEL. 2024;13(16):.

Transcriptome-based identification of key actin-binding proteins associated with high metastatic potential in breast cancer
Müller C, Schmalfeldt B, Müller V, Schmalfeldt B, Windhorst S
FRONT MOL BIOSCI. 2024;11:1440276.

The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases
Müller S, Jücker M
INT J MOL SCI. 2024;25(10):.

Functional characterization of PI3K C2 domain mutations detected in breast cancer circulating tumor cells and metastatic cells
Smit D, Brauer H, Horn S, Yigit G, Haider M, Pogenberg V, Schumacher U, Pantel K, Jücker M
CELL SIGNAL. 2024;121:.

Analysis of the Plasticity of Circulating Tumor Cells Reveals Differentially Regulated Kinases During the Suspension-to-Adherent Transition
Smit D, Hoffer K, Bettin B, Kriegs M, Cayrefourcq L, Schumacher U, Pantel K, Alix-Panabières C, Jücker M
CANCER MED-US. 2024;13(20):e70339.

All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines
Tian L, Smit D, Popova N, Horn S, Velasquez L, Huber S, Jucker M
INT J MOL SCI. 2024;25(4):.

2023

Cryo-EM structures of actin binding proteins as tool for drug discovery
Dahlstroem C, Paraschiakos T, Sun H, Windhorst S
BIOCHEM PHARMACOL. 2023;214:115680.

Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021
Ehm P, Bettin B, Jücker M
BBA-MOL CELL RES. 2023;1870(5):.

Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases
Ehm P, Linnebacher M, Block A, Rehbach C, Jücker M
CELL SIGNAL. 2023;108:110720.

Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants
Ehm P, Nelson N, Giehler S, Schaks M, Bettin B, Kirchmair J, Jücker M
CELL SIGNAL. 2023;101:.

SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model
Ehm P, Rietow R, Wegner W, Bußmann L, Kriegs M, Dierck K, Horn S, Streichert T, Horstmann M, Jücker M
CELLS-BASEL. 2023;12(13):1798.

The Alarmone Diadenosine Tetraphosphate as a Cosubstrate for Protein AMPylation
Frese M, Saumer P, Yuan Y, Herzog D, Höpfner D, Itzen A, Marx A
ANGEW CHEM INT EDIT. 2023;62(8):e202213279.

Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
Genduso S, Freytag V, Schetler D, Kirchner L, Schiecke A, Maar H, Wicklein D, Gebauer F, Bröker K, Stürken C, Milde-Langosch K, Oliveira-Ferrer L, Ricklefs F, Ewald F, Wolters-Eisfeld G, Riecken K, Unrau L, Krause L, Bohnenberger H, Offermann A, Perner S, Sebens S, Lamszus K, Diehl L, Linder S, Jücker M, Schumacher U, Lange T
J HEMATOL ONCOL. 2023;16(1):.

The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3
Höpfner D, Cichy A, Pogenberg V, Krisp C, Mezouar S, Bach N, Grotheer J, Zarza S, Martinez E, Bonazzi M, Feige M, Sieber S, Schlüter H, Itzen A
COMMUN BIOL. 2023;6(1):1124.

Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b
Kaspers M, Pogenberg V, Pett C, Ernst S, Ecker F, Ochtrop P, Groll M, Hedberg C, Itzen A
NAT COMMUN. 2023;14(1):2245.

Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis
Kempska J, Oliveira-Ferrer L, Grottke A, Qi M, Alawi M, Meyer F, Borgmann K, Hamester F, Eylmann K, Rossberg M, Smit D, Jücker M, Laakmann E, Witzel I, Schmalfeldt B, Müller V, Legler K
FRONT ONCOL. 2023;13:1129682.

The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells
Küster L, Paraschiakos T, Karakurt K, Schumacher U, Diercks B, Windhorst S
BIOSCIENCE REP. 2023;43(2):.

Acetylation reprograms MITF target selectivity and residence time
Louphrasitthiphol P, Loffreda A, Pogenberg V, Picaud S, Schepsky A, Friedrichsen H, Zeng Z, Lashgari A, Thomas B, Patton E, Wilmanns M, Filippakopoulos P, Lambert J, Steingrímsson E, Mazza D, Goding C
NAT COMMUN. 2023;14(1):6051.

Sample Preparation for Time-Resolved Serial Crystallography: Practical Considerations
Mehrabi P, Schulz E
2023. Advanced Methods in Structural Biology. Sousa Â, Passarinha L (Hrsg.). 1. Aufl. New York, NY: Humana Press, 361-379.

Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography
Mehrabi P, Sung S, von Stetten D, Prester A, Hatton C, Kleine-Döpke S, Berkes A, Gore G, Leimkohl J, Schikora H, Kollewe M, Rohde H, Wilmanns M, Tellkamp F, Schulz E
NAT COMMUN. 2023;14(1):2365.

Ex Vivo Model of Neuroblastoma Plasticity
Schäfer P, Muhs S, Turnbull L, Garwal P, Maar H, Yorgan T, Tolosa E, Lange T, Windhorst S
CANCERS. 2023;15(4):.

Generating Patient-Derived HCC Cell Lines Suitable for Predictive In Vitro and In Vivo Drug Screening by Orthotopic Transplantation
Staffeldt L, Mattert G, Riecken K, Rövenstrunk G, Volkmar A, Heumann A, Moustafa M, Jücker M, Fehse B, Schumacher U, Lüth S, Kah J
CELLS-BASEL. 2023;13(1):.

The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism
Tian L, Smit D, Jücker M
INT J MOL SCI. 2023;24(3):.

Structural basis for subversion of host cell actin cytoskeleton during Salmonella infection
Yuan B, Scholz J, Wald J, Thuenauer R, Hennell James R, Ellenberg I, Windhorst S, Faix J, Marlovits T
SCI ADV. 2023;9(49):eadj5777.

2022

TIGIT blockade repolarizes AML-associated TIGIT+ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
Brauneck F, Fischer B, Witt M, Muschhammer J, Oelrich J, da Costa Avelar P, Tsoka S, Bullinger L, Seubert E, Smit D, Bokemeyer C, Ackermann C, Wellbrock J, Haag F, Fiedler W
J IMMUNOTHER CANCER. 2022;10(12):.

Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL)
Ehm P, Grottke A, Bettin B, Jücker M
CELL SIGNAL. 2022;93:.

Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer
Elakad O, Häupl B, Labitzky V, Yao S, Küffer S, von Hammerstein-Equord A, Danner B, Jücker M, Urlaub H, Lange T, Ströbel P, Oellerich T, Bohnenberger H
NPJ PRECIS ONCOL. 2022;6(1):.

DIAPH1 facilitates paclitaxel-mediated cytotoxicity of ovarian cancer cells
Flat W, Borowski S, Paraschiakos T, Blechner C, Windhorst S
BIOCHEM PHARMACOL. 2022;197:.

JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative Neoplasm (MPN)
Glück M, Dally L, Jücker M, Ehm P
INT J BIOCHEM CELL B. 2022;149:.

The role of sphingosine-1-phosphate in bone remodeling and osteoporosis
Grewe J, Knapstein P, Donat A, Jiang S, Smit D, Xie W, Keller J
BONE RES. 2022;10(1):.

Revisiting AMPylation through the lens of Fic enzymes
Gulen B, Itzen A
TRENDS MICROBIOL. 2022;30(4):350-363.

MicroRNAs: Emerging Regulators of Metastatic Bone Disease in Breast Cancer
Haider M, Smit D, Taipaleenmäki H
CANCERS. 2022;14(3):.

Key Role of Hyaluronan Metabolism for the Development of Brain Metastases in Triple-Negative Breast Cancer
Hamester F, Stürken C, Legler K, Eylmann K, Möller K, Roßberg M, Gorzelanny C, Bauer A, Windhorst S, Schmalfeldt B, Laakmann E, Müller V, Witzel I, Oliveira-Ferrer L
CELLS-BASEL. 2022;11(20):.

Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM+ and CD90+ Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model
Moustafa M, Dähling K, Günther A, Riebandt L, Smit D, Riecken K, Schröder C, Zhuang R, Krech T, Kriegs M, Fehse B, Izbicki J, Fischer L, Nashan B, Li J, Jücker M
CANCERS. 2022;14(8):.

The Functional Role of Extracellular Matrix Proteins in Cancer
Popova N, Jücker M
CANCERS. 2022;14(1):.

AKT Isoforms as a Target in Cancer and Immunotherapy
Smit D, Jücker M
2022. PI3K and AKT Isoforms in Immunity. Dominguez-Villar M (Hrsg.). 1. Aufl. Cham: Springer, 409-436.

2021

Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1
Du J, Wrisberg M, Gulen B, Stahl M, Pett C, Hedberg C, Lang K, Schneider S, Itzen A
NAT COMMUN. 2021;12(1):.

Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
Ecker V, Stumpf M, Brandmeier L, Neumayer T, Pfeuffer L, Engleitner T, Ringshausen I, Nelson N, Jücker M, Wanninger S, Zenz T, Wendtner C, Manske K, Steiger K, Rad R, Müschen M, Ruland J, Buchner M
NAT COMMUN. 2021;12(1):3526.

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD
Fauser J, Gulen B, Pogenberg V, Pett C, Pourjafar-Dehkordi D, Krisp C, Höpfner D, König G, Schlüter H, Feige M, Zacharias M, Hedberg C, Itzen A
NAT COMMUN. 2021;12(1):.

Current Advances in Covalent Stabilization of Macromolecular Complexes for Structural Biology
Fauser J, Itzen A, Gulen B
BIOCONJUGATE CHEM. 2021;32(5):879-890.

Interleukins as Mediators of the Tumor Cell-Bone Cell Crosstalk during the Initiation of Breast Cancer Bone Metastasis
Haider M, Ridlmaier N, Smit D, Taipaleenmäki H
INT J MOL SCI. 2021;22(6):2898.

Role of miRNAs in Breast Cancer-induced Bone Disease
Haider M, Zarrer J, Smit D, Hesse E, Taipaleenmäki H
OSTEOLOGIE. 2021;30(3):211-221.

Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
Hinz N, Baranowsky A, Horn M, Kriegs M, Sibbertsen F, Smit D, Clezardin P, Lange T, Schinke T, Jücker M
CELLS-BASEL. 2021;10(2):.

AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review
Hinz N, Jücker M
CANCERS. 2021;13(10):2287.

Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer
Hofmann B, Picksak A, Kwiatkowski M, Grupp K, Jücker M, Bachmann K, Mercanoglu B, Izbicki J, Kahlert C, Bockhorn M, Güngör C, Ewald F, Wolters-Eisfeld G
GLYCOBIOLOGY. 2021;2021:.

Rcf proteins and their differential specificity for respiratory chain complexes: A unique role for Rcf2 on oxygen sensitive supercomplexes?
Homberg B, Römpler K, Wissel M, Callegari S, Deckers M
BBA-MOL CELL RES. 2021;1868(12):.

Erratum: Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation
Höpfner D, Fauser J, Kaspers M, Pett C, Hedberg C, Itzen A
ISCIENCE. 2021;24(7):102731.

2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: identification of a new and potent inhibitor
Löhndorf A, Hosang L, Dohle W, Odoardi F, Waschkowski S, Rosche A, Bauche A, Winzer R, Tolosa E, Windhorst S, Marry S, Flügel A, Potter B, Diercks B, Guse A
BBA-MOL CELL RES. 2021;1868(6):118988.

DIAPH1 regulates chromosomal instability of cancer cells by controlling microtubule dynamics
Miao S, Schäfer P, Nojszewski J, Meyer F, Windhorst S
EUR J CELL BIOL. 2021;100(3):.

Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density
Middelkamp M, Ruck L, Krisp C, Sumisławski P, Mohammadi B, Dottermusch M, Meister V, Küster L, Schlüter H, Windhorst S, Neumann J
ACTA NEUROPATHOL COM. 2021;9(1):185.

AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2
Nelson N, Razeto A, Gilardi A, Grättinger M, Kirchmair J, Jücker M
BIOCHEM BIOPH RES CO. 2021;568:110-115.

Combined Targeting of AKT and mTOR Synergistically Inhibits Formation of Primary Colorectal Carcinoma Tumouroids In Vitro: A 3D Tumour Model for Pre-therapeutic Drug Screening
Nörz D, Mullins C, Smit D, Linnebacher M, Hagel G, Mirdogan A, Siekiera J, Ehm P, Izbicki J, Block A, Thastrup O, Jücker M
ANTICANCER RES. 2021;41(5):2257-2275.

Mechanism of BIP-4 mediated inhibition of InsP3Kinase-A
Paraschiakos T, Flat W, Chen Y, Kirchmair J, Windhorst S
BIOSCIENCE REP. 2021;41(7):.

The Role of mTOR Signaling as a Therapeutic Target in Cancer
Popova N, Jücker M
INT J MOL SCI. 2021;22(4):1743.

High Serum Levels of Wnt Signaling Antagonist Dickkopf-Related Protein 1 Are Associated with Impaired Overall Survival and Recurrence in Esophageal Cancer Patients
Ramirez J, Smit D, Viol F, Schrader J, Ghadban T, Pantel K, Izbicki J, Reeh M
CANCERS. 2021;13(19):.

SopD from Salmonella specifically inactivates Rab8
Savitskiy S, Itzen A
BBA-PROTEINS PROTEOM. 2021;1869(8):140661.

Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation
Savitskiy S, Wachtel R, Pourjafar-Dehkordi D, Kang H, Trauschke V, Lamb D, Sattler M, Zacharias M, Itzen A
ISCIENCE. 2021;24(1):.

Oncogenic activity and cellular functionality of melanoma associated antigen A3
Schäfer P, Paraschiakos T, Windhorst S
BIOCHEM PHARMACOL. 2021;192:.

Circulating tumor cells as a promising target for individualized drug susceptibility tests in cancer therapy
Smit D, Pantel K, Jücker M
BIOCHEM PHARMACOL. 2021;188:114589.

2020

Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis
Arnold J, Schattschneider J, Blechner C, Krisp C, Schlüter H, Schweizer M, Nalaskowski M, Oliveira-Ferrer L, Windhorst S
J EXP CLIN CANC RES. 2020;39(1):205.

Conformational control of small GTPases by AMPylation
Barthelmes K, Ramcke E, Kang H, Sattler M, Itzen A
P NATL ACAD SCI USA. 2020;117(11):5772-5781.

Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice
Blechner C, Becker L, Fuchs H, Rathkolb B, Prehn C, Adler T, Calzada-Wack J, Garrett L, Gailus-Durner V, Morellini F, Conrad S, Hölter S, Wolf E, Klopstock T, Adamski J, Busch D, de Angelis M, Schmeisser M, Windhorst S
NEUROSCI LETT. 2020;735:135206.

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies
Daub H, Traxler L, Ismajli F, Groitl B, Itzen A, Rant U
SCI REP-UK. 2020;10(1):9265.

Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination
Ernst S, Ecker F, Kaspers M, Ochtrop P, Hedberg C, Groll M, Itzen A
SCI ADV. 2020;6(20):eaaz8041.

Sortase-Mediated Quantifiable Enzyme Immobilization on Magnetic Nanoparticles
Fauser J, Savitskiy S, Fottner M, Trauschke V, Gulen B
BIOCONJUGATE CHEM. 2020;31(8):1883-1892.

Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture
Gulen B, Rosselin M, Fauser J, Albers M, Pett C, Krisp C, Pogenberg V, Schlüter H, Hedberg C, Itzen A
NAT CHEM. 2020;12(8):732-739.

The Endosteal Niche in Breast Cancer Bone Metastasis
Haider M, Smit D, Taipaleenmäki H
FRONT ONCOL. 2020;10:335.

Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation
Höpfner D, Fauser J, Kaspers M, Pett C, Hedberg C, Itzen A
ISCIENCE. 2020;23(12):.

Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila
Hu C, Kanellopoulos A, Richter M, Petersen M, Konietzny A, Tenedini F, Hoyer N, Cheng L, Poon C, Harvey K, Windhorst S, Parrish J, Mikhaylova M, Bagni C, Calderon de Anda F, Soba P
J NEUROSCI. 2020;40(9):1819-1833.

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity
Koch C, Kuske A, Joosse S, Yigit G, Sflomos G, Thaler S, Smit D, Werner S, Borgmann K, Gärtner S, Mossahebi Mohammadi P, Battista L, Cayrefourcq L, Altmüller J, Salinas-Riester G, Raithatha K, Zibat A, Goy Y, Ott L, Bartkowiak K, Tan T, Zhou Q, Speicher M, Müller V, Gorges T, Jücker M, Thiery J, Brisken C, Riethdorf S, Alix-Panabières C, Pantel K
EMBO MOL MED. 2020;12(9):.

Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice
Labitzky V, Baranowsky A, Maar H, Hanika S, Starzonek S, Ahlers A, Stübke K, Koziolek E, Heine M, Schäfer P, Windhorst S, Jücker M, Riecken K, Amling M, Schinke T, Schumacher U, Valentiner U, Lange T
CANCERS. 2020;12(2):.

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution
Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton E, Davidson I, Lambert J, Wilmanns M, Steingrímsson E, Mazza D, Goding C
MOL CELL. 2020;79(3):472-487.e10.

PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer
Marquard F, Jücker M
BIOCHEM PHARMACOL. 2020;172:113729.

Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1
Nelson N, Wundenberg T, Lin H, Rehbach C, Horn S, Windhorst S, Jücker M
BIOCHEM BIOPH RES CO. 2020;524(2):366-370.

Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer
Schaks M, Allgoewer K, Nelson N, Ehm P, Heumann A, Ewald F, Schumacher U, Simon R, Sauter G, Jücker M
BIOMEDICINES. 2020;8(7):.

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology
Schiedel M, Daub H, Itzen A, Jung M
CHEMBIOCHEM. 2020;21(8):1161-1166.

Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo
Schulte A, Ewald F, Spyra M, Smit D, Jiang W, Salamon J, Jücker M, Mautner V
INT J MOL SCI. 2020;21(4):.

High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors
Smit D, Cayrefourcq L, Haider M, Hinz N, Pantel K, Alix-Panabières C, Jücker M
CELLS-BASEL. 2020;9(9):.

Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets
Swart A, Steiner B, Gomez-Valero L, Schütz S, Hannemann M, Janning P, Irminger M, Rothmeier E, Buchrieser C, Itzen A, Panse V, Hilbi H
MBIO. 2020;11(2):.

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72
Vieweg S, Mulholland K, Brauning B, Kacharia N, Lai Y, Toth R, Singh P, Volpi I, Sattler M, Groll M, Itzen A, Muqit M
BIOCHEM J. 2020;477(9):1651-1668.

Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer
Voß H, Wurlitzer M, Smit D, Ewald F, Alawi M, Spohn M, Indenbirken D, Omidi M, David K, Juhl H, Simon R, Sauter G, Fischer L, Izbicki J, Molloy M, Nashan B, Schlüter H, Jücker M
CLIN EXP METASTAS. 2020;37(6):649-656.

Mice lacking plastin-3 display a specific defect of cortical bone acquisition
Yorgan T, Sari H, Rolvien T, Windhorst S, Failla A, Kornak U, Oheim R, Amling M, Schinke T
BONE. 2020;130:115062.

Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment
Zarrer J, Haider M, Smit D, Taipaleenmäki H
BIOMOLECULES. 2020;10(2):.

2019

Inositol hexakisphosphate increases the size of platelet aggregates
Brehm M, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch B, Riley A, Mayr G, Potter B, Windhorst S
BIOCHEM PHARMACOL. 2019;161:14-25.

New options of cancer treatment employing InsP6
Brehm M, Windhorst S
BIOCHEM PHARMACOL. 2019;163:206-214.

Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins
Ehm P, Lange F, Hentschel C, Jepsen A, Glück M, Nelson N, Bettin B, de Bruyn Kops C, Kirchmair J, Nalaskowski M, Jücker M
CELL SIGNAL. 2019;63:109380.

The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain
Grueb S, Muhs S, Popp Y, Schmitt S, Geyer M, Lin Y, Windhorst S
SCI REP-UK. 2019;9(1):5352.

Distinct functions of AKT isoforms in breast cancer: a comprehensive review
Hinz N, Jücker M
CELL COMMUN SIGNAL. 2019;17(1):154.

Liquid application method for time-resolved analyses by serial synchrotron crystallography
Mehrabi P, Schulz E, Agthe M, Horrell S, Bourenkov G, von Stetten D, Leimkohl J, Schikora H, Schneider T, Pearson A, Tellkamp F, Miller R
NAT METHODS. 2019;16(10):979-982.

Time-resolved crystallography reveals allosteric communication aligned with molecular breathing
Mehrabi P, Schulz E, Dsouza R, Müller-Werkmeister H, Tellkamp F, Miller R, Pai E
SCIENCE. 2019;365(6458):1167-1170.

Radial somatic F-actin organization affects growth cone dynamics during early neuronal development
Meka D, Scharrenberg R, Zhao B, Kobler O, König T, Schaefer I, Schwanke B, Klykov S, Richter M, Eggert D, Windhorst S, Dotti C, Kreutz M, Mikhaylova M, Calderon de Anda F
EMBO REP. 2019;20(12):e47743.

Phosphorylation of Ser111 in Rab8a Modulates Rabin8-Dependent Activation by Perturbation of Side Chain Interaction Networks
Pourjafar-Dehkordi D, Vieweg S, Itzen A, Zacharias M
BIOCHEMISTRY-US. 2019;58(33):3546-3554.

The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia
Velthaus A, Cornils K, Hennigs J, Grüb S, Stamm H, Wicklein D, Bokemeyer C, Heuser M, Windhorst S, Fiedler W, Wellbrock J
CANCERS. 2019;11(11):.

A novel 6-pyrophosphorylating IP6 kinase (IP6-6K) discovered in the protozoon Trichomonas vaginalis
Wundenberg T, Nalaskowski M, Löser B, Fanick W, Hackl T, Fürnkranz U, Rehbach C, Lin H, Mayr G
MOL BIOCHEM PARASIT. 2019;227:53-63.

A toolkit for expression of Strep-tagged enhanced green fluorescent protein concatemers in mammalian cells
Zweifel A, Giehler S, Nalaskowski M
ANAL BIOCHEM. 2019;586:113430.

2018

Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells
Bäder S, Glaubke E, Grüb S, Muhs S, Wellbrock J, Nalaskowski M, Lange T, Windhorst S
BIOCHEM J. 2018;475(12):2057-2071.

Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases
Hänel L, Gosau T, Maar H, Valentiner U, Schumacher U, Riecken K, Windhorst S, Hansen N, Heikaus L, Wurlitzer M, Nolte I, Schlüter H, Lange T
SCI REP-UK. 2018;8(1):13986.

Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells
Nalaskowski M, Ehm P, Rehbach C, Nelson N, Täger M, Modest K, Jücker M
CELL SIGNAL. 2018;49:87-94.

Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance
Rubio-Cosials A, Schulz E, Lambertsen L, Smyshlyaev G, Rojas-Cordova C, Forslund K, Karaca E, Bebel A, Bork P, Barabas O
CELL. 2018;173(1):208-220.e20.

Clinical relevance of cytoskeleton associated proteins for ovarian cancer
Schiewek J, Schumacher U, Lange T, Joosse S, Wikman H, Pantel K, Mikhaylova M, Kneussel M, Linder S, Schmalfeldt B, Oliveira-Ferrer L, Windhorst S
J CANCER RES CLIN. 2018;144(11):2195-2205.

The hit-and-return system enables efficient time-resolved serial synchrotron crystallography
Schulz E, Mehrabi P, Müller-Werkmeister H, Tellkamp F, Jha A, Stuart W, Persch E, De Gasparo R, Diederich F, Pai E, Miller R
NAT METHODS. 2018;15(11):901-904.

2017

A set of enhanced green fluorescent protein concatemers for quantitative determination of nuclear localization signal strength.
Böhm J, Thavaraja R, Giehler S, Nalaskowski M
ANAL BIOCHEM. 2017;533:48-55.

Strong fascin expression promotes metastasis independent of its F-actin bundling activity
Heinz L, Muhs S, Schiewek J, Grüb S, Nalaskowski M, Lin Y, Wikman H, Oliveira-Ferrer L, Lange T, Wellbrock J, Konietzny A, Mikhaylova M, Windhorst S
ONCOTARGET. 2017;8(66):110077-110091.

PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression
Hohensee I, Chuang H, Grottke A, Werner S, Schulte A, Horn S, Lamszus K, Bartkowiak K, Witzel I, Westphal M, Matschke J, Glatzel M, Jücker M, Pukrop T, Pantel K, Wikman H
ONCOTARGET. 2017;8(4):6155-6168.

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia
Latuske E, Stamm H, Klokow M, Vohwinkel G, Muschhammer J, Bokemeyer C, Jücker M, Kebenko M, Fiedler W, Wellbrock J
ONCOTARGET. 2017;8(17):29187-29201.

Low-dose fixed-target serial synchrotron crystallography
Owen R, Axford D, Sherrell D, Kuo A, Ernst O, Schulz E, Miller R, Mueller-Werkmeister H
ACTA CRYSTALLOGR D. 2017;73(Pt 4):373-378.

Protein crystals IR laser ablated from aqueous solution at high speed retain their diffractive properties: Applications in high-speed serial crystallography
Schulz E
J APPL CRYSTALLOGR. 2017.

SHIP1, but not an AML-derived SHIP1 mutant, suppresses myeloid leukemia growth in a xenotransplantation mouse model
Täger M, Horn S, Latuske E, Ehm P, Schaks M, Nalaskowski M, Fehse B, Fiedler W, Stocking C, Wellbrock J, Jücker M
GENE THER. 2017;24(11):749-753.

Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells
Toulany M, Maier J, Iida M, Rebholz S, Holler M, Grottke A, Jüker M, Wheeler D, Rothbauer U, Rodemann H
CELL DEATH DISCOV. 2017;(3):17072.

Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing
Volksdorf T, Heilmann J, Eming S, Schawjinski K, Zorn-Kruppa M, Ueck C, Vidal-Y-Sy S, Windhorst S, Jücker M, Moll I, Brandner J
AM J PATHOL. 2017;187(6):1301-1312.

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types
Windhorst S, Song K, Gazdar A
BIOCHEM PHARMACOL. 2017;137:1-9.

Microtubules Modulate F-actin Dynamics during Neuronal Polarization
Zhao B, Meka P, Scharrenberg R, König T, Schwanke B, Kobler O, Windhorst S, Kreutz M, Mikhaylova M, Calderon de Anda F
SCI REP-UK. 2017;7(1):9583.

2016

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions
Behrens K, Triviai I, Schwieger M, Tekin N, Alawi M, Spohn M, Indenbirken D, Ziegler M, Müller U, Alexander W, Stocking C
BLOOD. 2016;127(26):3369-81.

Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity
Chen L, DeWispelaere A, Dastvan F, Osborne W, Blechner C, Windhorst S, Daum G
PLOS ONE. 2016;11(5):e0155726.

Outcome and features of acute kidney injury complicating hypoxic hepatitis at the medical intensive care unit
Drolz A, Horvatits T, Roedl K, Rutter K, Staufer K, Haider D, Zauner C, Heinz G, Schellongowski P, Kluge S, Trauner M, Fuhrmann V
ANN INTENSIVE CARE. 2016;6(1):61.

Control of aromatase in hippocampal neurons
Fester L, Brandt N, Windhorst S, Pröls F, Bläute C, Rune G
J STEROID BIOCHEM. 2016;160:9-14.

Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4
Grottke A, Ewald F, Lange T, Nörz D, Herzberger C, Bach J, Grabinski N, Gräser L, Höppner F, Nashan B, Schumacher U, Jücker M
PLOS ONE. 2016;11(1):e0146370.

Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells
Holler M, Grottke A, Mueck K, Manes J, Jücker M, Rodemann H, Toulany M
PLOS ONE. 2016;11(5):e0154745.

Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines
Köster J, Leggewie B, Blechner C, Brandt N, Fester L, Rune G, Schweizer M, Kindler S, Windhorst S
CELL SIGNAL. 2016;28(1):83-90.

Akt isoform specific effects in ovarian cancer progression
Linnerth-Petrik N, Santry L, Moorehead R, Jücker M, Wootton S, Petrik J
ONCOTARGET. 2016;7(46):74820-74833.

Diaphanous-related formin 1 as a target for tumor therapy
Lin Y, Windhorst S
BIOCHEM SOC T. 2016;44(5):1289-1293.

2015

The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin
Ashour D, Pelka B, Jaaks P, Wundenberg T, Blechner C, Zobiak B, Failla A, Windhorst S
CYTOSKELETON. 2015;72(2):93-100.

The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies
Ehm P, Nalaskowski M, Wundenberg T, Jücker M
NUCLEUS-PHILA. 2015;6(2):154-64.

Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma
Ewald F, Nörz D, Grottke A, Bach J, Herzberger C, Hofmann B, Nashan B, Jücker M
J CANCER. 2015;6(12):1195-205.

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
Hofmann B, Schlüter L, Lange P, Mercanoglu B, Ewald F, Fölster A, Picksak A, Harder S, El Gammal A, Grupp K, Güngör C, Drenckhan A, Schlüter H, Wagener C, Izbicki J, Jücker M, Bockhorn M, Wolters-Eisfeld G
MOL CANCER. 2015;14(1):109.

ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts
Kebenko M, Drenckhan A, Gros S, Jücker M, Grabinski N, Ewald F, Grottke A, Schultze A, Izbicki J, Bokemeyer C, Wellbrock J, Fiedler W
CELL SIGNAL. 2015;27(2):373-81.

Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion
Lin Y, Bhuwania R, Gromova K, Failla A, Lange T, Riecken K, Linder S, Kneussel M, Izbicki J, Windhorst S
ONCOTARGET. 2015;6(21):18577-89.

Ex vivo aorta patch model for analysis of cellular adhesion
Lin Y, Thata R, Failla A, Geissen M, Daum G, Windhorst S
TISSUE CELL. 2015;47(3):266-272.

Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation
Nebel M, Zhang B, Odoardi F, Flügel A, Potter B, Guse A
Messenger (Los Angel). 2015;4(1):104-111.

Discontinuing MEK inhibitors in tumor cells with an acquired resistance increases migration and invasion
Nörz D, Grottke A, Bach J, Herzberger C, Hofmann B, Nashan B, Jücker M, Ewald F
CELL SIGNAL. 2015;27(11):2191-200.

Real-time investigation of dynamic protein crystallization in living cells
Schönherr R, Klinge M, Rudolph J, Fita K, Rehders D, Lübber F, Schneegans S, Majoul I, Duszenko M, Betzel C, Brandariz-Nuñez A, Martinez-Costas J, Duden R, Redecke L
STRUCT DYNAM-US. 2015;2(4):041712.

The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells
Schröder D, Tödter K, Gonzalez B, Franco-Echevarría E, Rohaly G, Blechner C, Lin H, Mayr G, Windhorst S
BIOCHEM PHARMACOL. 2015;96(2):143-50.

Proteomic analysis of the rare Uracoan rattlesnake Crotalus vegrandis venom: Evidence of a broad arsenal of toxins
Viala V, Hildebrand D, Fucase T, Sciani J, Prezotto-Neto J, Riedner M, Sanches L, Nishimura P, Oguiura N, Pimenta D, Schlüter H, Betzel C, Arni R, Spencer P
TOXICON. 2015;107(Pt B):234-51.

Venomics of the Australian eastern brown snake (Pseudonaja textilis): Detection of new venom proteins and splicing variants
Viala V, Hildebrand D, Trusch M, Fucase T, Sciani J, Pimenta D, Arni R, Schlüter H, Betzel C, Mirtschin P, Dunstan N, Spencer P
TOXICON. 2015;107(Pt B):252-65.

Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects
Wellbrock J, Latuske E, Köhler J, Wagner K, Stamm H, Vettorazzi E, Vohwinkel G, Klokow M, Uibeleisen R, Ehm P, Riecken K, Loges S, Thol F, Schubert C, Amling M, Jücker M, Bokemeyer C, Heuser M, Krauter J, Fiedler W
CLIN CANCER RES. 2015.

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic acid induced 2
Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood A, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen S, Klefstrom J, Wilmanns M, Müller V, Pantel K, Wikman-Kocher H
CANCER DISCOV. 2015;5(5):506-19.

2014

"Alkohol und Nikotin"-Konzept und Evaluation eines interdisziplinären Wahlfachs mit OSPE im Studienabschnitt Medizin 1
Bergelt C, Lauke-Wettwer H, Petersen-Ewert C, Jücker M, Bauer C
GMS J MED EDU. 2014;31(1):1-20.

H2S preconditioning of human adipose tissue-derived stem cells increases their efficacy in an in vitro model of cell therapy for simulated ischemia
Dongó E, Benkő Z, Csizmazia Á, Marosi G, Grottke A, Jücker M, Schumacher U, Kiss L
LIFE SCI. 2014;113(1-2):14-21.

Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
Ewald F, Nörz D, Grottke A, Hofmann B, Nashan B, Jücker M
INVEST NEW DRUG. 2014;32(6):1144-54.

Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells
Grabinski N, Ewald F
INVEST NEW DRUG. 2014;32(6):1096-1104.

AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice
Grabinski N, Möllmann K, Milde-Langosch K, Müller V, Schumacher U, Brandt B, Pantel K, Jücker M
CELL SIGNAL. 2014;26(5):1021-9.

Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase
Kublun I, Ehm P, Brehm M, Nalaskowski M
BIOCHIMIE. 2014;102:117-23.

Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells
Lin Y, Izbicki J, König A, Habermann J, Blechner C, Lange T, Schumacher U, Windhorst S
INT J CANCER. 2014;134(7):1571-82.

Expression, Purification and preliminary X-Ray diffraction of a pathogenic bacterial protease from Stenotrophomonas maltophilia
Negm A, Windhorst S, Betzel C, Akrem A, Weber W
World J Pharm Pharm Sci. 2014;3(10):13-23.

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5
Riley A, Windhorst S, Lin H, Potter B
CHEMBIOCHEM. 2014;15(1):57-67.

Structure of an Escherichia coli Hfq:RNA complex at 0.97 Å resolution
Schulz E, Barabas O
ACTA CRYSTALLOGR F. 2014;70(Pt 11):1492-7.

Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose
Tsuzuki T, Takano S, Sakaguchi N, Kudoh T, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse A, Kameda T, Hirokawa T, Kumaki Y, Arisawa M, Potter B, Shuto S
Messenger (Los Angel). 2014;3(1-2):35-51.

Discovery of InsP6-kinases as InsP6 dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio
Wundenberg T, Grabinski N, Lin H, Mayr G
BIOCHEM J. 2014.

2013

RabGEFs are a major determinant for specific Rab membrane targeting
Blümer J, Rey J, Dehmelt L, Mazel T, Wu Y, Bastiaens P, Goody R, Itzen A
J CELL BIOL. 2013;200(3):287-300.

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA
Brehm M, Wundenberg T, Williams J, Mayr G, Shears S
J CELL SCI. 2013;126(Pt 2):437-44.

Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Chang L, Schwarzenbach H, Meyer-Staeckling S, Brandt B, Mayr G, Weitzel J, Windhorst S
MOL CANCER RES. 2013.

Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma
Ewald F, Grabinski N, Grottke A, Windhorst S, Nörz D, Carstensen L, Staufer K, Hofmann B, Diehl F, David K, Schumacher U, Nashan B, Jücker M
INT J CANCER. 2013;133(9):2065-76.

Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate
Helmis C, Blechner C, Lin H, Schweizer M, Mayr G, Nielsen P, Windhorst S
BIOSCIENCE REP. 2013;33(5):.

Optimizing E. coli-based membrane protein production using Lemo21(DE3) and GFP-fusions
Hjelm A, Schlegel S, Baumgarten T, Klepsch M, Wickström D, Drew D, de Gier J
Methods Mol Biol. 2013;1033:381-400.

Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists
Moreau C, Kirchberger T, Swarbrick J, Bartlett S, Fliegert R, Yorgan T, Bauche A, Harneit A, Guse A, Potter B
J MED CHEM. 2013;56(24):10079-102.

Runx1 is essential at two stages of early murine B-cell development
Niebuhr B, Kriebitzsch N, Fischer M, Behrens K, Günther T, Alawi M, Bergholz U, Müller U, Roscher S, Ziegler M, Buchholz F, Grundhoff A, Stocking C
BLOOD. 2013;122(3):413-23.

Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling
Schneider K, Fuchs C, Dobay A, Rottach A, Qin W, Wolf P, Álvarez-Castro J, Nalaskowski M, Kremmer E, Schmid V, Leonhardt H, Schermelleh L
NUCLEIC ACIDS RES. 2013;41(9):4860-76.

Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A
Schröder D, Rehbach C, Seyffarth C, Neuenschwander M, Kries J, Windhorst S
BIOCHEM BIOPH RES CO. 2013;439(2):228-34.

Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation
Windhorst S, Lin H, Blechner C, Fanick W, Brandt L, Brehm M, Mayr G
BIOCHEM J. 2013;450(1):115-25.

2012

Functional characterization and immune recognition of the extracellular superoxide dismutase from the human pathogenic parasite Onchocerca volvulus (OvEC-SOD).
Ajonina-Ekoti I, Ndjonka D, Tanyi M, Wilbertz M, Younis A, Boursou D, Kurosinski M, Eberle R, Lüersen K, Perbandt M, Breloer M, Brattig N, Liebau E
ACTA TROP. 2012;124(1):15-26.

Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.
Brauer H, Strauss J, Wegner W, Müller-Tidow C, Horstmann M, Jücker M
CELL SIGNAL. 2012;24(11):2095-2101.

Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus.
García-Fernández R, Pons T, Meyer A, Perbandt M, González-González Y, Gil D, de Los Angeles Chávez M, Betzel C, Redecke L
ACTA CRYSTALLOGR F. 2012;68(Pt 11):1289-1293.

Structural insights into serine protease inhibition by a marine invertebrate BPTI Kunitz-type inhibitor.
García-Fernández R, Pons T, Perbandt M, Valiente P, Talavera A, González-González Y, Rehders D, Chávez M, Betzel C, Redecke L
J STRUCT BIOL. 2012;180(2):271-279.

Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells.
Grabinski N, Ewald F, Hofmann B, Staufer K, Schumacher U, Nashan B, Jücker M
MOL CANCER. 2012;11:85.

Linking NAADP to ion channel activity: a unifying hypothesis.
Guse A, Andreas H
SCI SIGNAL. 2012;5(221):18.

Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain.
Hofmann B, Jücker M
CELL SIGNAL. 2012;24(10):1950-1954.

A novel Entamoeba histolytica inositol phosphate kinase catalyzes the formation of 5PP-Ins(1,2,3,4,6)P(5)
Löser B, Nalaskowski M, Fanick W, Lin H, Tannich E, Mayr G
MOL BIOCHEM PARASIT. 2012;181(1):49-52.

Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.
Meyer R, Nalaskowski M, Ehm P, Schröder C, Naj X, Brehm M, Mayr G
BIOL CHEM. 2012;393(3):149-160.

Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells.
Moreau C, Kirchberger T, Zhang B, Thomas M, Weber K, Guse A, Potter B
J MED CHEM. 2012;55(4):1478-1489.

A toolkit for graded expression of green fluorescent protein fusion proteins in mammalian cells.
Nalaskowski M, Ehm P, Giehler S, Mayr G
ANAL BIOCHEM. 2012;428(1):24-27.

The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei.
Nalaskowski M, Metzner A, Brehm M, Labiadh S, Brauer H, Grabinski N, Mayr G, Jücker M
CELL SIGNAL. 2012;24(3):621-628.

Optimizing membrane protein overexpression in the Escherichia coli strain Lemo21(DE3)
Schlegel S, Löfblom J, Lee C, Hjelm A, Klepsch M, Strous M, Drew D, Slotboom D, de Gier J
J MOL BIOL. 2012;423(4):648-59.

Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.
Schmid F, Fliegert R, Westphal T, Bauche A, Guse A
J BIOL CHEM. 2012;287(39):32525-32534.

Structure analysis of Entamoeba histolytica DNMT2 (EhMeth)
Schulz E, Roth H, Ankri S, Ficner R
PLOS ONE. 2012;7(6):e38728.

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.
Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse A, Haag F, Adriouch S, Koch-Nolte F
PLOS ONE. 2012;7(7):41269.

A Plasmodium multi-domain protein possesses multiple inositol phosphate kinase activities.
Stritzke C, Nalaskowski M, Fanick W, Lin H, Mayr G
MOL BIOCHEM PARASIT. 2012;186(2):134-138.

Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc
Voigt F, Reuter M, Kasaruho A, Schulz E, Pillai R, Barabas O
RNA. 2012;18(12):2128-34.

Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model.
Wehr C, Müller F, Schüler J, Tomann T, Nitschke C, Seismann H, Spillner E, Klingner K, Schneider-Merck T, Binder M, Fiebig H, Mertelsmann R, Trepel M
INT J CANCER. 2012;131(2):10-20.

Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.
Windhorst S, Minge D, Bähring R, Hüser S, Schob C, Blechner C, Lin H, Mayr G, Kindler S
CELL SIGNAL. 2012;24(3):750-757.

Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasis.
Wundenberg T, Mayr G
BIOL CHEM. 2012;393(9):979-998.

2011

Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major
Dickmanns A, Damerow S, Neumann P, Schulz E, Lamerz A, Routier F, Ficner R
J MOL BIOL. 2011;405(2):461-78.

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells
Grabinski N, Bartkowiak K, Grupp K, Brandt B, Pantel K, Jücker M
CELL SIGNAL. 2011;23(12):1952-1960.

Posttranscriptional regulation of the p85α adapter subunit of phosphatidylinositol 3-kinase in human leukemia cells
Hofmann B, Hoxha E, Mohr E, Schulz K, Jücker M
LEUKEMIA LYMPHOMA. 2011;52(3):467-477.

Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.
Moreau C, Ashamu G, Bailey V, Galione A, Guse A, Potter B
ORG BIOMOL CHEM. 2011;9(1):278-290.

Venom peptide analysis of Vipera ammodytes meridionalis (Viperinae) and Bothrops jararacussu (Crotalinae) demonstrates subfamily-specificity of the peptidome in the family Viperidae
Munawar A, Trusch M, Georgieva D, Spencer P, Frochaux V, Harder S, Arni R, Duhalov D, Genov N, Schlüter H, Betzel C
MOL BIOSYST. 2011;7(12):3298-3307.

Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
Nalaskowski M, Fliegert R, Ernst O, Brehm M, Fanick W, Windhorst S, Lin H, Giehler S, Hein J, Lin Y, Mayr G
J BIOL CHEM. 2011;286(6):4500-4510.

A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.
Qi N, Jung K, Wang M, Na L, Yang Z, Zhang L, Guse A, Zhang L
CHEM COMMUN. 2011;47(33):9462-9464.

CD38: a NAADP degrading enzyme.
Schmid F, Bruhn S, Weber K, Mittrücker H, Guse A
FEBS LETT. 2011;585(22):3544-3548.

Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.
Schmidt A, Oberle N, Weiss E, Vobis D, Frischbutter S, Baumgrass R, Falk C, Haag M, Brügger B, Lin H, Mayr G, Reichardt P, Gunzer M, Suri-Payer E, Krammer P
SCI SIGNAL. 2011;4(204):90.

Crystal structure analysis of the polysialic acid specific O-acetyltransferase NeuO
Schulz E, Bergfeld A, Ficner R, Mühlenhoff M
PLOS ONE. 2011;6(3):e17403.

Knitting and snipping: chaperones in β-helix folding
Schulz E, Ficner R
CURR OPIN STRUC BIOL. 2011;21(2):232-9.

Structure analysis of Entamoeba histolytica enolase
Schulz E, Tietzel M, Tovy A, Ankri S, Ficner R
ACTA CRYSTALLOGR D. 2011;67(Pt 7):619-27.

Risk of recurrence and survival after relapse in patients with Ewing sarcoma.
Stahl M, Ranft A, Paulussen M, Bölling T, Vieth V, Bielack S, Görtitz I, Braun-Munzinger G, Hardes J, Jürgens H, Dirksen U
PEDIATR BLOOD CANCER. 2011;57(4):549-553.

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Windhorst S, Kalinina T, Schmid K, Blechner C, Kriebitzsch N, Hinsch R, Chang L, Herich L, Schumacher U, Mayr G
INT J CANCER. 2011;129(6):1300-1309.

2010

CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex.
Andreyeva A, Leshchyns´ka I, Knepper M, Betzel C, Redecke L, Sytnyk V, Schachner M
PLOS ONE. 2010;5(8):12018.

Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells
Binder M, Léchenne B, Ummanni R, Scharf C, Balabanov S, Trusch M, Schlüter H, Braren I, Spillner E, Trepel M
PLOS ONE. 2010;5(12):e15992.

Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.
Bruzzone S, Basile G, Chothi M, Nobbio L, Usai C, Jacchetti E, Schenone A, Guse A, Francesco D, Antonio D, Zocchi E
J BIOL CHEM. 2010;285(27):21165-21174.

Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.
Cordiglieri C, Francesca O, Zhang B, Nebel M, Kawakami N, Klinkert W, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan V, Dornmair K, Dammermann W, Potter B, Guse A, Flügel A
BRAIN. 2010;133(7):1930-1943.

Quality control of inclusion bodies in Escherichia coli.
Jürgen B, Breitenstein A, Urlacher V, Büttner K, Lin H, Hecker M, Schweder T, Neubauer P
MICROB CELL FACT. 2010;9:41.

Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca(2+)-mobilizing activity in T-lymphocytes.
Li L, Siebrands C, Yang Z, Zhang L, Guse A, Zhang L
ORG BIOMOL CHEM. 2010;8(8):1843-1848.

Synthesis and nonradioactive micro-analysis of diphosphoinositol phosphates by HPLC with postcolumn complexometry.
Lin H, Lindner K, Mayr G
Methods Mol Biol. 2010;645:103-122.

Percutaneous tissue-engineered pulmonary valved stent implantation.
Lutter G, Metzner A, Jahnke T, Bombien R, Boldt J, Iino K, Cremer J, Stock U
ANN THORAC SURG. 2010;89(1):259-263.

Percutaneous pulmonary polyurethane valved stent implantation.
Metzner A, Iino K, Steinseifer U, Uebing A, de Buhr W, Cremer J, Lutter G
J THORAC CARDIOV SUR. 2010;139(3):748-752.

Percutaneous pulmonary valve replacement: autologous tissue-engineered valved stents.
Metzner A, Stock U, Iino K, Fischer G, Huemme T, Boldt J, Braesen J, Bein B, Renner J, Cremer J, Lutter G
CARDIOVASC RES. 2010;88(3):453-461.

Functional cooperation between CREM and GCNF directs gene expression in haploid male germ cells.
Rajkovic M, Iwen K, Hofmann P, Harneit A, Weitzel J
NUCLEIC ACIDS RES. 2010;38(7):2268-2278.

Revolutionizing membrane protein overexpression in bacteria
Schlegel S, Klepsch M, Gialama D, Wickström D, Slotboom D, de Gier J
MICROB BIOTECHNOL. 2010;3(4):403-11.

Comparative analysis of cytoplasmic membrane proteomes of Escherichia coli using 2D blue native/SDS-PAGE
Schlegel S, Klepsch M, Wickström D, Wagner S, de Gier J
Methods Mol Biol. 2010;619:257-69.

Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding
Schulz E, Dickmanns A, Urlaub H, Schmitt A, Mühlenhoff M, Stummeyer K, Schwarzer D, Gerardy-Schahn R, Ficner R
NAT STRUCT MOL BIOL. 2010;17(2):210-5.

Structure analysis of endosialidase NF at 0.98 A resolution
Schulz E, Neumann P, Gerardy-Schahn R, Sheldrick G, Ficner R
ACTA CRYSTALLOGR D. 2010;66(Pt 2):176-80.

Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF
Schulz E, Schwarzer D, Frank M, Stummeyer K, Mühlenhoff M, Dickmanns A, Gerardy-Schahn R, Ficner R
J MOL BIOL. 2010;397(1):341-51.

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.
Sun M, Hillmann P, Hofmann B, Hart J, Vogt P
P NATL ACAD SCI USA. 2010;107(35):15547-15552.

Inositol-1,4,5-trisphosphate-3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumour cells by two functional activities.
Windhorst S, Fliegert R, Blechner C, Möllmann K, Hosseini Z, Guenther T, Eiben M, Chang L, Lin H, Fanick W, Schumacher U, Brandt B, Mayr G
J BIOL CHEM. 2010;285(8):5541-5554.

2009

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist.
Dammermann W, Zhang B, Nebel M, Cordiglieri C, Francesca O, Kirchberger T, Kawakami N, Dowden J, Schmid F, Dornmair K, Hohenegger M, Flügel A, Guse A, Potter B
P NATL ACAD SCI USA. 2009;106(26):10678-10683.

Second messenger signaling: multiple receptors for NAADP.
Guse A
CURR BIOL. 2009;19(13):521-523.

[Medical education in a bachelors and masters system]
Harendza S, Guse A
BUNDESGESUNDHEITSBLA. 2009;52(9):929-932.

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.
Kirchberger T, Moreau C, Wagner G, Fliegert R, Siebrands C, Nebel M, Schmid F, Harneit A, Francesca O, Flügel A, Potter B, Guse A
BIOCHEM J. 2009.

Emerging roles of NAD+ and its metabolites in cell signaling.
Koch Nolte F, Haag F, Guse A, Lund F, Ziegler M
SCI SIGNAL. 2009;2(57):1.

Structural analysis and detection of biological inositol pyrophosphates reveals that the VIP/PPIP5K family are 1/3-kinases.
Lin H, Fridy P, Ribeiro A, Choi J, Barma D, Vogel G, Falck J, Shears S, York J, Mayr G
J BIOL CHEM. 2009;284(3):1863-1872.

Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.
Metzner A, Precht C, Fehse B, Fiedler W, Stocking C, Günther A, Mayr G, Jücker M
GENE THER. 2009;16(4):570-573.

Einführung eines Mentorenprogramms für den Ersten Abschnitt des Studiums der Humanmedizin: Ergebnisse eines Pilotprojektes
Petersen-Ewert C, Kurré J, Scholl J, Guse A, Bullinger M
GMS J MED EDU. 2009;26(3):1-6.

Phosphoinositide and inositol phosphate analysis in lymphocyte activation.
Sauer K, Huang Y, Lin H, Sandberg M, Mayr G
Curr Protoc Immunol. 2009;11:1.

Activation of the P2X7 ion channel by soluble and covalently bound ligands.
Schwarz N, Fliegert R, Adriouch S, Seman M, Guse A, Haag F, Koch Nolte F
PURINERG SIGNAL. 2009;5(2):139-149.

Prostate specific antigen: one out of five disulfide bridges determines inactivation by reduction.
Weber W, Buck F, Meyer A, Hilz H
BIOCHEM BIOPH RES CO. 2009;379(4):1101-1106.

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11
zur Stadt U, Rohr J, Seifert W, Koch F, Grieve S, Pagel J, Strauss J, Kasper B, Nürnberg G, Becker C, Maul-Pavicic A, Beutel K, Janka G, Griffiths G, Ehl S, Hennies H
AM J HUM GENET. 2009;85(4):482-492.

2008

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.
Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse A, Seman M, Haag F, Koch Nolte F
FASEB J. 2008;22(3):861-869.

Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.
Alpatov R, Shi Y, Munguba G, Moghimi B, Joo J, Bungert J, Sugrue S
MOL CELL BIOL. 2008;28(5):1584-1595.

Assembly and structural analysis of a covalently closed nano-scale DNA cage.
Andersen F, Knudsen B, Oliveira C, Frøhlich R, Krüger D, Bungert J, Agbandje-McKenna M, McKenna R, Juul S, Veigaard C, Koch J, Rubinstein J, Guldbrandtsen B, Hede M, Karlsson G, Andersen A, Pedersen J, Knudsen B
NUCLEIC ACIDS RES. 2008;36(4):1113-1119.

Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer.
Bernhard H, Neudorfer J, Gebhard K, Conrad H, Hermann C, Nährig J, Fend F, Weber W, Busch D, Peschel C
CANCER IMMUNOL IMMUN. 2008;57(2):271-280.

Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice.
Böer U, Cierny I, Krause D, Heinrich A, Lin H, Mayr G, Hiemke C, Knepel W
NEUROPSYCHOPHARMACOL. 2008;33(10):2407-2415.

Non-transferrin-bound iron in plasma following administration of oral iron drugs.
Dresow B, Petersen D, Fischer R, Nielsen P
BIOMETALS. 2008;21(3):273-276.

Back from the dormant stage: second messenger cyclic ADP-ribose essential for Toxoplasma gondii pathogenicity.
Guse A
SCI SIGNAL. 2008;1(17):18.

NAADP: a universal Ca2+ trigger.
Guse A, Lee H
SCI SIGNAL. 2008;1(44):10.

Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.
Horn S, Bergholz U, Jücker M, McCubrey J, Trümper L, Stocking C, Bäsecke J
ONCOGENE. 2008;27(29):4096-4106.

Overexpression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase inhibits GM-CSF-dependent colony formation of CD34+ hematopoietic progenitor cells.
Hoxha E, Fehse B, Ortmeyer G, Stocking C, Mayr G, Jücker M
LEUKEMIA LYMPHOMA. 2008;49(6):1206-1208.

Immobilization of the first dimension in 2D blue native/SDS-PAGE allows the relative quantification of membrane proteomes
Klepsch M, Schlegel S, Wickström D, Friso G, van Wijk K, Persson J, de Gier J, Wagner S
METHODS. 2008;46(2):48-53.

Tuning Escherichia coli for membrane protein overexpression
Wagner S, Klepsch M, Schlegel S, Appel A, Draheim R, Tarry M, Högbom M, van Wijk K, Slotboom D, Persson J, de Gier J
P NATL ACAD SCI USA. 2008;105(38):14371-6.

Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.
Windhorst S, Blechner C, Lin H, Elling C, Nalaskowski M, Kirchberger T, Guse A, Mayr G
BIOCHEM J. 2008;414(3):407-417.

2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.
Zhang B, Wagner G, Weber K, Garnham C, Morgan A, Galione A, Guse A, Potter B
J MED CHEM. 2008;51(6):1623-1636.

2007

Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase.
Brehm M, Schenk T, Zhou X, Fanick W, Lin H, Windhorst S, Nalaskowski M, Kobras M, Shears S, Mayr G
BIOCHEM J. 2007;408(3):335-345.

Regulation of calcium signalling by adenine-based second messengers.
Fliegert R, Gasser A, Guse A
BIOCHEM SOC T. 2007;35(1):109-114.

Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b.
Fliegert R, Glassmeier G, Schmid F, Cornils K, Genisyuerek S, Harneit A, Schwarz J, Guse A
FEBS J. 2007;274(3):704-713.

Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica.
Gentsch M, Kuschel M, Schlegel S, Barth G
FEMS YEAST RES. 2007;7(3):380-390.

Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis.
Kasten-Pisula U, Windhorst S, Dahm-Daphi J, Mayr G, Dikomey E
RADIOTHER ONCOL. 2007;83(3):296-303.

CD83 modulates B Cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.
Kretschmer B, Lüthje K, Guse A, Ehrlich S, Koch Nolte F, Haag F, Fleischer B, Breloer M
PLOS ONE. 2007;2(1):755.

Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Metzner A, Horstmann M, Fehse B, Ortmeyer G, Niemeyer C, Stocking C, Mayr G, Jücker M
GENE THER. 2007;14(8):699-703.

Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction.
Partida-Sanchez S, Gasser A, Fliegert R, Siebrands C, Dammermann W, Shi G, Mousseau B, Sumoza-Toledo A, Bhagat H, Walseth T, Guse A, Lund F
J IMMUNOL. 2007;179(11):7827-7839.

Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization.
Schwoerer A, Blütner C, Brandt S, Binder S, Siebrands C, Ehmke H, Friederich P
ANESTHESIOLOGY. 2007;106(5):967-976.

Nuclear localization of enhanced green fluorescent protein homomultimers.
Seibel N, Eljouni J, Nalaskowski M, Hampe W
ANAL BIOCHEM. 2007;368(1):95-99.

Inhibition of HERG channels by the local anaesthetic articaine.
Siebrands C, Friederich P
EUR J ANAESTH. 2007;24(2):148-153.

Structural requirements of human ether-a-go-go-related gene channels for block by bupivacaine.
Siebrands C, Friederich P
ANESTHESIOLOGY. 2007;106(3):523-531.

NAADP mobilizes calcium from the endoplasmic reticular Ca(2+) store in T-lymphocytes.
Steen M, Kirchberger T, Guse A
J BIOL CHEM. 2007;282(26):18864-18871.

Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.
Wischnewski F, Friese O, Pantel K, Schwarzenbach H
MOL CANCER RES. 2007;5(7):749-759.

T3-mediated gene expression is independent of PGC-1alpha
Wulf A, Harneit A, Weitzel J
MOL CELL ENDOCRINOL. 2007;270(1-2):57-63.

2006

Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
Ehmann F, Horn S, Garcia-Palma L, Wegner W, Fiedler W, Giehl K, Mayr G, Jücker M
LEUKEMIA LYMPHOMA. 2006;47(7):1387-1391.

Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives.
Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund F, Zhang L, Potter B, Guse A
BRIT J PHARMACOL. 2006;149(4):337-344.

Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains.
Nalaskowski M, Windhorst S, Stockebrand M, Mayr G
BIOL CHEM. 2006;387(5):583-593.

Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains
Xu J, Yang Z, Dammermann W, Zhang L, Guse A, Zhang L
J MED CHEM. 2006;49(18):5501-12.

2005

Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer
Avril N, Sassen S, Schmalfeldt B, Naehrig J, Rutke S, Weber W, Werner M, Graeff H, Schwaiger M, Kuhn W
J CLIN ONCOL. 2005;23(30):7445-53.

Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes
Dammermann W, Guse A
J BIOL CHEM. 2005;280(22):21394-9.

Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.
García-Palma L, Horn S, Haag F, Diessenbacher P, Streichert T, Mayr G, Jücker M
BRIT J HAEMATOL. 2005;131(5):628-631.

Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation.
Harst A, Lin H, Obermann Wolfgang M
BIOCHEM J. 2005;387(3):789-796.

Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.
Mayr G, Windhorst S, Hillemeier K
J BIOL CHEM. 2005;280(14):13229-13240.

2004

Identification of the actin-binding domain of Ins(1,4,5)P3 3-kinase isoform B (IP3K-B)
Brehm M, Schreiber I, Bertsch U, Wegner A, Mayr G
BIOCHEM J. 2004;382(1):353-362.

Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle.
Horn S, Endl E, Fehse B, Weck M, Mayr G, Jücker M
LEUKEMIA. 2004;18(11):1839-1849.

Change of extracellular cAMP concentration is a sensitive reporter for bacterial fitness in high-cell-density cultures of Escherichia coli.
Lin H, Hoffmann F, Rozkov A, Enfors S, Rinas U, Neubauer P
BIOTECHNOL BIOENG. 2004;87(5):602-613.

An optimized fixation and extraction technique for high resolution of inositol phosphate signals in rodent brain.
Lorke D, Gustke H, Mayr G
NEUROCHEM RES. 2004;29(10):1887-1896.

The families of kinases removing the Ca2+ releasing second messenger Ins(1,4,5)P3.
Nalaskowski M, Mayr G
CURR MOL MED. 2004;4(3):277-290.

2003

Activated G alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and Akt.
Ballou L, Lin H, Fan G, Jiang Y, Lin R
J BIOL CHEM. 2003;278(26):23472-23479.

An increase in the expression and total activity of endogenous p60(c-Src) in several factor-independent mutants of a human GM-CSF-dependent leukemia cell line (TF-1)
Horn S, Meyer J, Stocking C, Ostertag W, Jücker M
ONCOGENE. 2003;22(46):7170-80.

Analysis of subcellular calcium signals in T-lymphocytes.
Kunerth S, Mayr G, Koch-Nolte F, Guse A
CELL SIGNAL. 2003;15(8):783-792.

Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation.
Lin H, Ballou L, Lin R
FEBS LETT. 2003;540(1-3):106-110.

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.
Lotz Gregor P, Lin H, Harst A, Obermann Wolfgang M
J BIOL CHEM. 2003;278(19):17228-17235.

Rat inositol 1,4,5-trisphosphate 3-kinase C is enzymatically specialized for basal cellular inositol trisphosphate phosphorylation and shuttles actively between nucleus and cytoplasm.
Nalaskowski M, Bertsch U, Fanick W, Stockebrand M, Schmale H, Mayr G
J BIOL CHEM. 2003;278(22):19765-19776.

Metabolic load of recombinant protein production: inhibition of cellular capacities for glucose uptake and respiration after induction of a heterologous gene in Escherichia coli.
Neubauer P, Lin H, Mathiszik B
BIOTECHNOL BIOENG. 2003;83(1):53-64.

2002

Hierarchy of stroma-derived factors in supporting growth of stroma-dependent hemopoietic cells membrane-bound SCF is sufficient to confer stroma competence to epithelial cells
Friel J, Itoh K, Bergholz U, Jücker M, Stocking C, Harrison P, Ostertag W
GROWTH FACTORS. 2002;20(1):35-51.

Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.
Guse A, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey V, Matsuda A, Mayr G, Oppenheimer N, Schuber F, Potter B
BIOCHEMISTRY-US. 2002;41(21):6744-6751.

The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization.
Nalaskowski M, Deschermeier C, Fanick W, Mayr G
BIOCHEM J. 2002;366(2):549-556.

Structure of the functional domain of the major grass-pollen allergen Phlp 5b.
Rajashankar K, Bufe A, Weber W, Eschenburg S, Lindner B, Betzel C
ACTA CRYSTALLOGR D. 2002;58(Pt 7):1175-1181.

Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex.
Schwarzmann N, Kunerth S, Weber K, Mayr G, Guse A
J BIOL CHEM. 2002;277(52):50636-50642.

Role of the general stress response during strong overexpression of a heterologous gene in Escherichia coli.
Schweder T, Lin H, Jürgen B, Breitenstein A, Riemschneider S, Khalameyzer V, Gupta A, Büttner K, Neubauer P
APPL MICROBIOL BIOT. 2002;58(3):330-337.

The major extracellular protease of the nosocomial pathogen Stenotrophomonas maltophilia: characterization of the protein and molecular cloning of the gene.
Windhorst S, Frank E, Georgieva D, Genov N, Buck F, Borowski P, Weber W
J BIOL CHEM. 2002;277(13):11042-11049.

2001

Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor
Ballou L, Tian P, Lin H, Jiang Y, Lin R
J BIOL CHEM. 2001;276(44):40910-6.

Physiological responses to mixing in large scale bioreactors.
Enfors S, Jahic M, Rozkov A, Xu B, Hecker M, Jürgen B, Krüger E, Schweder T, Hamer G, O'Beirne D, Noisommit-Rizzi N, Reuss M, Boone L, Hewitt C, McFarlane C, Nienow A, Kovacs T, Trägårdh C, Fuchs L, Revstedt J, Friberg P, Hjertager B, Blomsten G, Skogman H, Hjort S, Hoeks F, Lin H, Neubauer P, van der Lans R, Luyben K, Vrabel P, Manelius A
J BIOTECHNOL. 2001;85(2):175-185.

Transient tyrosine phosphorylation of human ryanodine receptor upon T cell stimulation.
Guse A, Tsygankov A, Weber K, Mayr G
J BIOL CHEM. 2001;276(37):34722-34727.

The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro
Horn S, Meyer J, Heukeshoven J, Fehse B, Schulze C, Li S, Frey J, Poll S, Stocking C, Jücker M
LEUKEMIA. 2001;15(1):112-20.

Cellular Responses to Strong Overexpression of Recombinant Genes in Escherichia Coli
Lin H, Hanschke , Nicklisch , Riemschneider , Meyer , Gupta , Neubauer P
2001. Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology. Springer Netherlands, .

Determination of the maximum specific uptake capacities for glucose and oxygen in glucose-limited fed-batch cultivations of Escherichia coli.
Lin H, Mathiszik B, Xu B, Enfors S, Neubauer P
BIOTECHNOL BIOENG. 2001;73(5):347-357.

Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling.
Schöttelndreier H, Potter B, Mayr G, Guse A
CELL SIGNAL. 2001;13(12):895-899.

Assay for ADP-ribosyl cyclase by reverse-phase high-performance liquid chromatography.
Schweitzer K, Mayr G, Guse A
ANAL BIOCHEM. 2001;299(2):218-226.

Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.
Yang S, Yu J, Mayr G, Hofmann F, Larsson O, Berggren P
FASEB J. 2001;15(10):1753-1763.

2000

Tenascin-R inhibits regrowth of optic fibers in vitro and persists in the optic nerve of mice after injury
Becker T, Anliker B, Becker C, Taylor J, Schachner M, Meyer R, Bartsch U
GLIA. 2000;29(4):330-46.

Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling.
Berg I, Potter B, Mayr G, Guse A
J CELL BIOL. 2000;150(3):581-588.

The second messenger binding site of inositol 1,4,5-trisphosphate 3-kinase is centered in the catalytic domain and related to the inositol trisphosphate receptor site.
Bertsch U, Deschermeier C, Fanick W, Girkontaite I, Hillemeier K, Johnen H, Weglöhner W, Emmrich F, Mayr G
J BIOL CHEM. 2000;275(3):1557-1564.

Monitoring of genes that respond to overproduction of an insoluble recombinant protein in Escherichia coli glucose-limited fed-batch fermentations.
Jürgen B, Lin H, Riemschneider S, Scharf C, Neubauer P, Schmid R, Hecker M, Schweder T
BIOTECHNOL BIOENG. 2000;70(2):217-224.

Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium.
Laussmann T, Pikzack C, Thiel U, Mayr G, Vogel G
EUR J BIOCHEM. 2000;267(8):2447-2451.

Influence of controlled glucose oscillations on a fed-batch process of recombinant Escherichia coli.
Lin H, Neubauer P
J BIOTECHNOL. 2000;79(1):27-37.

Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.
Oude Weernink P, Schulte P, Guo Y, Wetzel J, Amano M, Kaibuchi K, Haverland S, Voss M, Schmidt M, Mayr G, Jakobs K
J BIOL CHEM. 2000;275(14):10168-10174.

1999

A novel A-isoform-like inositol 1,4,5-trisphosphate 3-kinase from chicken erythrocytes exhibits alternative splicing and conservation of intron positions between vertebrates and invertebrates.
Bertsch U, Haefs M, Möller M, Deschermeier C, Fanick W, Kitzerow A, Ozaki S, Meyer H, Mayr G
GENE. 1999;228(1-2):61-71.

Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230.
Gehrmann T, Gülkan H, Suer S, Herberg F, Balla A, Vereb G, Mayr G, Heilmeyer L
BBA-BIOMEMBRANES. 1999;1437(3):341-356.

Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose.
Guse A, Da Silva C, Berg I, Skapenko A, Weber K, Heyer P, Hohenegger M, Ashamu G, Schulze-Koops H, Potter B, Mayr G
NATURE. 1999;398(6722):70-73.

Pharmacological activation of the ryanodine receptor in Jurkat T-lymphocytes.
Hohenegger M, Berg I, Weigl L, Mayr G, Potter B, Guse A
BRIT J PHARMACOL. 1999;128(6):1235-1240.

Beta1-integrins mediate Ca2+-signalling and T cell spreading via divergent pathways.
Schöttelndreier H, Mayr G, Guse A
CELL SIGNAL. 1999;11(8):611-619.

Growth rate related concentration changes of the starvation response regulators sigmaS and ppGpp in glucose-limited fed-batch and continuous cultures of Escherichia coli.
Teich A, Meyer S, Lin H, Andersson L, Enfors S, Neubauer P
BIOTECHNOL PROGR. 1999;15(1):123-129.

1998

Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography.
Da Silva C, Potter B, Mayr G, Guse A
J CHROMATOGR B. 1998;707(1-2):43-50.

Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-signalling activity of cyclic ADP-ribose in T-lymphocytes are not functionally related.
Da Silva C, Schweitzer K, Heyer P, Malavasi F, Mayr G, Guse A
FEBS LETT. 1998;439(3):291-296.

Crystallization and preliminary X-ray crystallographic analysis of the EGF receptor ectodomain.
Degenhardt M, Weber W, Eschenburg S, Dierks K, Funari S, Rapp G, Betzel C
ACTA CRYSTALLOGR D. 1998;54(Pt 5):999-1001.

Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice.
Jun K, Choi G, Yang S, Choi K, Kim H, Chan G, Storm D, Albert C, Mayr G, Lee C, Shin H
LEARN MEMORY. 1998;5(4-5):317-330.

Amplification of ColE1 related plasmids in recombinant cultures of Escherichia coli after IPTG induction.
Teich A, Lin H, Andersson L, Meyer S, Neubauer P
J BIOTECHNOL. 1998;64(2-3):197-210.

1997

Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
Albert C, Safrany S, Bembenek M, Reddy K, Reddy K, Falck J, Bröcker M, Shears S, Mayr G
BIOCHEM J. 1997;327(2):553-560.

Vicinal thiols are involved in inositol 1,2,3,5,6-pentakisphosphate 5-phosphatase activity from fetal calf thymus.
Bandyopadhyay U, Kaiser T, Rudolf M, Schultz C, Guse A, Mayr G
BIOCHEM BIOPH RES CO. 1997;240(1):146-149.

Suppression of thyrotropin receptor-G protein-phospholipase C coupling by activation of protein kinase C in thyroid carcinoma cells.
Broecker M, Mayr G, Derwahl M
ENDOCRINOLOGY. 1997;138(9):3787-3796.

Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytes.
Guse A, Berg I, Da Silva C, Potter B, Mayr G
J BIOL CHEM. 1997;272(13):8546-8550.

Ca(2+)-signalling in human T-lymphocytes. Potential roles for cyclic ADP-ribose and 2'-phospho-cyclic ADP-ribose.
Guse A, Da Silva C, Potter B, Mayr G
ADV EXP MED BIOL. 1997;419:431-436.

1-(5-phospho-beta-D-ribosyl)2'-phosphoadenosine 5'-phosphate cyclic anhydride induced Ca2+ release in human T-cell lines.
Guse A, Da Silva C, Weber K, Armah C, Ashamu G, Schulze C, Potter B, Mayr G, Hilz H
EUR J BIOCHEM. 1997;245(2):411-417.

Unique properties of the capacitative Ca(2+)-entry antagonist LU 52396: its inhibitory activity depends on the activation state of the cells.
Guse A, de Wit C, Klokow T, Schweitzer K, Mayr G
CELL CALCIUM. 1997;22(2):91-97.

Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate.
Larsson O, Barker C, Sjöholm A, Carlqvist H, Michell R, Bertorello A, Nilsson T, Honkanen R, Mayr G, Zwiller J, Berggren P
SCIENCE. 1997;278(5337):471-474.

Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation.
Möst J, Spötl L, Mayr G, Gasser A, Sarti A, Dierich M
BLOOD. 1997;89(2):662-671.

Integrin-mediated intracellular Ca2+ signaling in Jurkat T lymphocytes.
Weismann M, Guse A, Sorokin L, Bröker B, Frieser M, Hallmann R, Mayr G
J IMMUNOL. 1997;158(4):1618-1627.

1996

Characterization of the C-terminal domain of ras-GTPase-activating protein (ras-GAP) as substrate for epidermal growth factor receptor and p60c-src kinase.
Borowski P, Kornetzky L, Heiland M, Roloff S, Weber W, Laufs R
Biochem Mol Biol Int. 1996;39(3):635-646.

Regulation of cADP-ribose-induced Ca2+ release by Mg2+ and inorganic phosphate.
Guse A, Silva C, Weber K, Ashamu G, Potter B, Mayr G
J BIOL CHEM. 1996;271(39):23946-23953.

Expression of the neural adhesion molecule L1 in the deafferented dentate gyrus
Jucker M, D'Amato F, Mondadori C, Mohajeri H, Magyar J, Bartsch U, Schachner M
NEUROSCIENCE. 1996;75(3):703-15.

1995

Inositol phosphate structural requisites for Ca2+ influx.
DeLisle S, Mayr G, Welsh M
AM J PHYSIOL-HEART C. 1995;268(6 Pt 1):1485-1491.

Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.
Guse A, Da Silva C, Emmrich F, Ashamu G, Potter B, Mayr G
J IMMUNOL. 1995;155(7):3353-3359.

Non-radioactive, isomer-specific inositol phosphate mass determinations: high-performance liquid chromatography-micro-metal-dye detection strongly improves speed and sensitivity of analyses from cells and micro-enzyme assays.
Guse A, Goldwich A, Weber K, Mayr G
J Chromatogr B Biomed Appl. 1995;672(2):189-198.

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.
Mayr G, Reed M, Wang P, Wang Y, Schweds J, Tegtmeyer P
CANCER RES. 1995;55(11):2410-2417.

Highly cooperative Ca2+ elevations in response to Ins(1,4,5)P3 microperfusion through a patch-clamp pipette.
Schrenzel J, Demaurex N, Foti M, Van Delden C, Jacquet J, Mayr G, Lew D, Krause K
BIOPHYS J. 1995;69(6):2378-2391.

Isolation of the myc transcription factor nucleoside diphosphate kinase and the multifunctional enzyme glyceraldehyde-3-phosphate dehydrogenase by cAMP affinity chromatography.
Weber B, Weber W, Buck F, Hilz H
INT J BIOCHEM CELL B. 1995;27(2):215-224.

1994

Crystallization of the EGF receptor ectodomain on US space mission STS-47.
Chr B, Gunther N, Poll S, Moore K, DeLucas L, ChE B, Weber W
MICROGRAVITY SCI TEC. 1994;7(3):242-245.

Second messenger specificity of the inositol trisphosphate receptor: reappraisal based on novel inositol phosphates.
DeLisle S, Radenberg T, Wintermantel M, Tietz C, Parys J, Pittet D, Welsh M, Mayr G
AM J PHYSIOL-HEART C. 1994;266(2 Pt 1):429-436.

Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.
Drayer [, Kaay V, Mayr G, Haastert V
EMBO J. 1994;13(7):1601-1609.

p53 oligomerization and DNA looping are linked with transcriptional activation.
Stenger J, Tegtmeyer P, Mayr G, Reed M, Wang Y, Wang P, Hough P, Mastrangelo I
EMBO J. 1994;13(24):6011-6020.

Protein microheterogeneity and crystal habits: the case of epidermal growth factor receptor isoforms as isolated in a multicompartment electrolyzer with isoelectric membranes.
Weber W, Wenisch E, Günther N, Marnitz U, Betzel C, Righetti P
J CHROMATOGR A. 1994;679(1):181-189.

1993

Crystallization and preliminary X-ray analysis of leukemia inhibitory factor.
Betzel C, Visanji M, Dauter Z, Fourme R, Weber W, Marnitz U, Boone T, Pope J, Miller J, Hawkins N
FEBS LETT. 1993;336(2):236-238.

Calcium signalling: comparison of the role of Ca2+ influx in excitable endocrine and non-excitable myeloid cells.
Schlegel W, Mollard P, Demaurex N, Theler J, Chiavaroli C, Guérineau N, Vacher P, Mayr G, Krause K, Wollheim C
Adv Second Messenger Phosphoprotein Res. 1993;28:143-152.

The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s).
Stephens L, Radenberg T, Thiel U, Vogel G, Khoo K, Dell A, Jackson T, Hawkins P, Mayr G
J BIOL CHEM. 1993;268(6):4009-4015.

1992

Regulation of Ca2+ influx in myeloid cells. Role of plasma membrane potential, inositol phosphates, cytosolic free [Ca2+], and filling state of intracellular Ca2+ stores.
Demaurex N, Schlegel W, Varnai P, Mayr G, Lew D, Krause K
J CLIN INVEST. 1992;90(3):830-839.

Metabolism of inositol phosphates in the protozoan Paramecium. Characterization of a novel inositol-hexakisphosphate-dephosphorylating enzyme.
Freund W, Mayr G, Tietz C, Schultz J
EUR J BIOCHEM. 1992;207(1):359-367.

Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro.
Harbers M, Borowski P, Fanick W, Lengyel H, Buck F, Hinsch K, Hilz H
CARCINOGENESIS. 1992;13(12):2403-2406.

A simple and rapid technique to process formalin-fixed, paraffin-embedded tissues for the detection of viruses by the polymerase chain reaction
Kiene P, Milde-Langosch K, Runkel M, Schulz K, Löning T
VIRCHOWS ARCH. 1992;420(3):269-73.

Inositol tetrakisphosphate isomers and elevation of cytosolic Ca2+ in vasopressin-stimulated insulin-secreting RINm5F cells.
Li G, Pralong W, Pittet D, Mayr G, Schlegel W, Wollheim C
J BIOL CHEM. 1992;267(7):4349-4356.

1991

Binding of sugar phosphates, inositol phosphates and phosphorylated amino acids to actin.
Gaertner A, Mayr G, Wegner A
EUR J BIOCHEM. 1991;198(1):67-71.

Masses of inositol phosphates in resting and tetanically stimulated vertebrate skeletal muscles.
Mayr G, Thieleczek R
BIOCHEM J. 1991;280(3):631-640.

3-Aminobenzamide inhibits cytotoxicity and adhesion of phorbol-ester-stimulated granulocytes to fibroblast monolayer cultures.
Meyer T, Lengyel H, Fanick W, Hilz H
EUR J BIOCHEM. 1991;197(1):127-133.

1990

The secreted form of the epidermal growth factor receptor. Characterization and crystallization of the receptor-ligand complex.
Günther N, Betzel C, Weber W
J BIOL CHEM. 1990;265(36):22082-22085.

Relation of phosphatidylinositol metabolism to glycolytic pathway in skeletal muscle membranes.
Heilmeyer L, Han J, Thieleczek R, Varsanyi M, Mayr G
MOL CELL BIOCHEM. 1990;99(2):111-116.

Synthesis and application of photoaffinity analogues of inositol 1,4,5-trisphosphate selectively substituted at the 1-phosphate group.
Schäfer R, Nehls-Sahabandu M, Grabowsky B, Dehlinger-Kremer M, Schulz I, Mayr G
BIOCHEM J. 1990;272(3):817-825.

1989

Inositol 1,4-bisphosphate is an allosteric activator of muscle-type 6-phosphofructo-1-kinase.
Mayr G
BIOCHEM J. 1989;259(2):463-470.

Chemoattractant receptor promotion of Ca2+ influx across the plasma membrane of HL-60 cells. A role for cytosolic free calcium elevations and inositol 1,3,4,5-tetrakisphosphate production.
Pittet D, Lew D, Mayr G, Monod A, Schlegel W
J BIOL CHEM. 1989;264(13):7251-7261.

Mass changes in inositol tetrakis- and pentakisphosphate isomers induced by chemotactic peptide stimulation in HL-60 cells.
Pittet D, Schlegel W, Lew D, Monod A, Mayr G
J BIOL CHEM. 1989;264(31):18489-18493.

The quantitative spectrum of inositol phosphate metabolites in avian erythrocytes, analysed by proton n.m.r. and h.p.l.c. with direct isomer detection.
Radenberg T, Scholz P, Bergmann G, Mayr G
BIOCHEM J. 1989;264(2):323-333.

Inositol polyphosphate-mediated repartitioning of aldolase in skeletal muscle triads and myofibrils.
Thieleczek R, Mayr G, Brandt N
J BIOL CHEM. 1989;264(13):7349-7356.

1988

Semisynthetic derivatives of inositol 1,4,5-trisphosphate substituted at the 1-phosphate group. Effects on calcium release from permeabilized guinea-pig parotid acinar cells and comparison with binding to aldolase A.
Henne V, Mayr G, Grabowski B, Koppitz B, Söling H
EUR J BIOCHEM. 1988;174(1):95-101.

A novel metal-dye detection system permits picomolar-range h.p.l.c. analysis of inositol polyphosphates from non-radioactively labelled cell or tissue specimens.
Mayr G
BIOCHEM J. 1988;254(2):585-591.

ADP-ribosyl proteins formed by pertussis toxin are specifically cleaved by mercury ions.
Meyer T, Koch R, Fanick W, Hilz H
Biol Chem Hoppe Seyler. 1988;369(7):579-583.

1987

Characterization of the calmodulin-binding sites of muscle phosphofructokinase and comparison with known calmodulin-binding domains.
Buschmeier B, Meyer H, Mayr G
J BIOL CHEM. 1987;262(20):9454-9462.

Interaction of calmodulin with phosphofructokinase: binding studies and evaluation of enzymatic and physicochemical changes.
Mayr G
METHOD ENZYMOL. 1987;139:745-763.

The only inositol tetrakisphosphate detectable in avian erythrocytes is the isomer lacking phosphate at position 3: a NMR study.
Mayr G, Dietrich W
FEBS LETT. 1987;213(2):278-282.

N pi-methylhistidine in myosin-light-chain kinase.
Meyer H, Mayr G
Biol Chem Hoppe Seyler. 1987;368(12):1607-1611.

5S-rRNA-containing ribonucleoproteins from rabbit muscle and liver. Complex and partial primary structures.
Nendza R, Digweed M, Meyer H, Erdmann V, Mayr G
EUR J BIOCHEM. 1987;169(1):85-95.

1986

2'-Phosphoadenylylation of eukaryotic proteins: a type of covalent modification.
Hilz H, Fanick W, Klapproth K
P NATL ACAD SCI USA. 1986;83(17):6267-6271.

Mammalian aldolases are isomer-selective high-affinity inositol polyphosphate binders.
Koppitz B, Vogel F, Mayr G
EUR J BIOCHEM. 1986;161(2):421-433.

1985

Steady-state kinetics of skeletal muscle myosin light chain kinase indicate a strong down regulation by products.
Geuss U, Mayr G, Heilmeyer L
EUR J BIOCHEM. 1985;153(2):327-334.

1984

Nonenzymic ADP-ribosylation of specific mitochondrial polypeptides.
Hilz H, Koch R, Fanick W, Klapproth K, Adamietz P
P NATL ACAD SCI USA. 1984;81(13):3929-3933.

Interaction of calmodulin with muscle phosphofructokinase. Changes of the aggregation state, conformation and catalytic activity of the enzyme.
Mayr G
EUR J BIOCHEM. 1984;143(3):513-520.

Interaction of calmodulin with muscle phosphofructokinase. Interplay with metabolic effectors of the enzyme under physiological conditions.
Mayr G
EUR J BIOCHEM. 1984;143(3):521-529.

1983

Phosphofructokinase is a calmodulin binding protein.
Mayr G, Heilmeyer L
FEBS LETT. 1983;159(1-2):51-57.

Shape and substructure of skeletal muscle myosin light chain kinase.
Mayr G, Heilmeyer L
BIOCHEMISTRY-US. 1983;22(18):4316-4326.

Skeletal muscle myosin light chain kinase. A refined structural model.
Mayr G, Heilmeyer L
FEBS LETT. 1983;157(2):225-231.

1978

Divergent denaturation of proteases by urea and dodecylsulfate in the absence of substrate.
Hilz H, Fanick W
Hoppe Seylers Z Physiol Chem. 1978;359(10):1447-1450.

[Steroid-cardiomyopathy: experimental generation, demonstration and quantification of its hemodynamic and contractile effects]
Strauer B, Beer K, Bürger S, Hübner G, Löhrs U, Mayr G, Meinardus A, Scherpe A
Verh Dtsch Ges Inn Med. 1978;84:679-682.

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