Franz Ricklefs
Priv.-Doz. Dr. med.
Franz Lennard Ricklefs
  • Oberarzt
  • Arbeitsgruppenleiter
  • Facharzt für Neurochirurgie
Arbeitsbereich

Standort

Hauptgebäude O10 , 2. Etage
Sprachen
Deutsch (Muttersprache)
Englisch

Fachgebiete

Tätigkeitsschwerpunkte

Publikationen

2024

Classification of Brain Tumors by Nanopore Sequencing of Cell-Free DNA from Cerebrospinal Fluid
Afflerbach A, Rohrandt C, Brändl B, Sönksen M, Hench J, Frank S, Börnigen D, Alawi M, Mynarek M, Winkler B, Ricklefs F, Synowitz M, Dührsen L, Rutkowski S, Wefers A, Müller F, Schoof M, Schüller U
CLIN CHEM. 2024;70(1):250-260.

Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features
Dottermusch M, Ryba A, Ricklefs F, Flitsch J, Schmid S, Glatzel M, Saeger W, Neumann J, Schüller U
ACTA NEUROPATHOL. 2024;147(1):16.

Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
Drexler R, Brembach F, Sauvigny J, Ricklefs F, Eckhardt A, Bode H, Gempt J, Lamszus K, Westphal M, Schüller U, Mohme M
ACTA NEUROPATHOL COM. 2024;12(1):9.

A prognostic neural epigenetic signature in high-grade glioma
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Göller P, Sahm F, Menstel J, Zimmer D, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
NAT MED. 2024;30(6):1622-1635.

Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
Drexler R, Khatri R, Schüller U, Eckhardt A, Ryba A, Sauvigny T, Dührsen L, Mohme M, Ricklefs T, Bode H, Hausmann F, Huber T, Bonn S, Voß H, Neumann J, Silverbush D, Hovestadt V, Suvà M, Lamszus K, Gempt J, Westphal M, Heiland D, Hänzelmann S, Ricklefs F
ACTA NEUROPATHOL. 2024;147(1):21.

Mean global DNA methylation serves as independent prognostic marker in IDH wild type glioblastoma
Eckhardt A, Drexler R, Schoof M, Struve N, Capper D, Jelgersma C, Onken J, Harter P, Weber K, Divé I, Rothkamm K, Hoffer K, Klumpp L, Ganser K, Petersen C, Ricklefs F, Kriegs M, Schüller U
NEURO-ONCOLOGY. 2024;26(3):503-513.

Doping of casted silk fibroin membranes with extracellular vesicles for regenerative therapy: a proof of concept
Fuest S, Salviano-Silva A, Maire C, Xu Y, Apel C, Grust A, Delle Coste A, Gosau M, Ricklefs F, Smeets R
SCI REP-UK. 2024;14(1):3553.

Distinct relapse pattern across molecular ependymoma types
Obrecht-Sturm D, Schoof M, Eckhardt A, Mynarek M, Gilbert M, Aldape K, Armstrong T, Ramaswamy V, Bockmayr M, von Hoff K, Fleischhack G, Adolph J, Tippelt S, Pfister S, Pajtler K, Sturm D, Drexler R, Ricklefs F, Stepien N, Gojo J, Pietsch T, Warmuth-Metz M, Kortmann R, Timmermann B, Haberler C, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2024 [Epub ahead of print].

Microsurgical Clipping of Unruptured Anterior Circulation Aneurysms-A Global Multicenter Investigation of Perioperative Outcomes
Sauvigny J, Drexler R, Pantel T, Ricklefs F, Catapano J, Wanebo J, Lawton M, Sanchin A, Hecht N, Vajkoczy P, Raygor K, Tonetti D, Abla A, El Naamani K, Tjoumakaris S, Jabbour P, Jankowitz B, Salem M, Burkhardt J, Wagner A, Wostrack M, Gempt J, Meyer B, Gaub M, Mascitelli J, Dodier P, Bavinzski G, Roessler K, Stroh N, Gmeiner M, Gruber A, Figueiredo E, Coelho A, Bervitskiy A, Anisimov E, Rzaev J, Krenzlin H, Keric N, Ringel F, Park D, Kim M, Marcati E, Cenzato M, Krause L, Westphal M, Dührsen L, Sauvigny T
NEUROSURGERY. 2024 [Epub ahead of print];94(6):1218-26.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Song F, Kovac V, Mohammadi B, Littau J, Scharfenberg F, Matamoros Angles A, Vanni I, Shafiq M, Orge L, Galliciotti G, Djakkani S, Linsenmeier L, Černilec M, Hartman K, Jung S, Tatzelt J, Neumann J, Damme M, Tschirner S, Lichtenthaler S, Ricklefs F, Sauvigny T, Schmitz M, Zerr I, Puig B, Tolosa E, Ferrer I, Magnus T, Rupnik M, Sepulveda-Falla D, Matschke J, Šmid L, Bresjanac M, Andreoletti O, Krasemann S, Foliaki S, Nonno R, Becker-Pauly C, Monzo C, Crozet C, Haigh C, Glatzel M, Curin Serbec V, Altmeppen H
ACTA NEUROPATHOL. 2024;148(1):2.

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
Tetzlaff S, Reyhan E, Layer N, Bengtson C, Heuer A, Schroers J, Faymonville A, Langeroudi A, Drewa N, Keifert E, Wagner J, Soyka S, Schubert M, Sivapalan N, Pramatarov R, Buchert V, Wageringel T, Grabis E, Wißmann N, Alhalabi O, Botz M, Bojcevski J, Campos J, Boztepe B, Scheck J, Conic S, Puschhof M, Villa G, Drexler R, Zghaibeh Y, Hausmann F, Hänzelmann S, Karreman M, Kurz F, Schröter M, Thier M, Suwala A, Forsberg-Nilsson K, Acuna C, Saez-Rodriguez J, Abdollahi A, Sahm F, Breckwoldt M, Suchorska B, Ricklefs F, Heiland D, Venkataramani V
CELL. 2024 [Epub ahead of print].

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Welsh J, Goberdhan D, O'Driscoll L, Buzas E, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks T, Erdbrügger U, Falcon-Perez J, Fu Q, Hill A, Lenassi M, Lim S, Mahoney M, Mohanty S, Möller A, Nieuwland R, Ochiya T, Sahoo S, Torrecilhas A, Zheng L, Zijlstra A, Abuelreich S, Bagabas R, Bergese P, Bridges E, Brucale M, Burger D, Carney R, Cocucci E, Crescitelli R, Hanser E, Harris A, Haughey N, Hendrix A, Ivanov A, Jovanovic-Talisman T, Kruh-Garcia N, Ku'ulei-Lyn Faustino V, Kyburz D, Lässer C, Lennon K, Lötvall J, Maddox A, Martens-Uzunova E, Mizenko R, Newman L, Ridolfi A, Rohde E, Rojalin T, Rowland A, Saftics A, Sandau U, Saugstad J, Shekari F, Swift S, Ter-Ovanesyan D, Tosar J, Useckaite Z, Valle F, Varga Z, van der Pol E, van Herwijnen M, Wauben M, Wehman A, Williams S, Zendrini A, Zimmerman A, Théry C, Witwer K
J EXTRACELL VESICLES. 2024;13(2):e12404.

2023

Multiple craniotomies in a single surgery - the resection of scattered brain metastases
Bschorer M, Ricklefs F, Sauvigny T, Westphal M, Dührsen L
NEUROSURG REV. 2023;46(1):70.

Targeted anticonvulsive treatment of IDH-wildtype glioblastoma based on DNA methylation subclasses
Drexler R, Göttsche J, Sauvigny T, Schüller U, Khatri R, Hausmann F, Hänzelmann S, Huber T, Bonn S, Heiland D, Delev D, Venkataramani V, Winkler F, Weller J, Zeyen T, Herrlinger U, Gempt J, Ricklefs F, Dührsen L
NEURO-ONCOLOGY. 2023;25(5):1006-1008.

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
bioRxiv. 2023.

Association of the classification of intraoperative adverse events (ClassIntra) with complications and neurological outcome after neurosurgical procedures: a prospective cohort study
Drexler R, Ricklefs F, Pantel T, Göttsche J, Nitzschke R, Zöllner C, Westphal M, Dührsen L
ACTA NEUROCHIR. 2023;165(8):2015-2027.

Defining benchmark outcomes for transsphenoidal surgery of pituitary adenomas: a multicenter analysis
Drexler R, Rotermund R, Smith T, Kilgallon J, Honegger J, Nasi-Kordhishti I, Gardner P, Gersey Z, Abdallah H, Jane J, Marino A, Knappe U, Uksul N, Rzaev J, Galushko E, Gormolysova E, Bervitskiy A, Schroeder H, Eördögh M, Losa M, Mortini P, Gerlach R, Azab M, Budohoski K, Rennert R, Karsy M, Couldwell W, Antunes A, Westphal M, Ricklefs F, Flitsch J
EUR J ENDOCRINOL. 2023;189(3):379-386.

Epigenetic profiling reveals a strong association between lack of 5-ALA fluorescence and EGFR amplification in IDH-wildtype glioblastoma
Drexler R, Sauvigny T, Schüller U, Eckhardt A, Maire C, Khatri R, Hausmann F, Hänzelmann S, Huber T, Bonn S, Bode H, Lamszus K, Westphal M, Dührsen L, Ricklefs F
NEURO-ONCOL PRACT. 2023;10(5):462-471.

DNA methylation subclasses predict the benefit from gross total tumor resection in IDH-wildtype glioblastoma patients
Drexler R, Schüller U, Eckhardt A, Filipski K, Hartung T, Harter P, Divé I, Forster M, Czabanka M, Jelgersma C, Onken J, Vajkoczy P, Capper D, Siewert C, Sauvigny T, Lamszus K, Westphal M, Dührsen L, Ricklefs F
NEURO-ONCOLOGY. 2023;25(2):315-325.

Crooke Cell Adenoma Confers Poorer Endocrinological Outcomes Compared with Corticotroph Adenoma: Results of a Multicenter, International Analysis
Findlay M, Drexler R, Azab M, Karbe A, Rotermund R, Ricklefs F, Flitsch J, Smith T, Kilgallon J, Honegger J, Nasi-Kordhishti I, Gardner P, Gersey Z, Abdallah H, Jane J, Marino A, Knappe U, Uksul N, Rzaev J, Bervitskiy A, Schroeder H, Eördögh M, Losa M, Mortini P, Gerlach R, Antunes A, Couldwell W, Budohoski K, Rennert R, Karsy M
WORLD NEUROSURG. 2023;180:e376-e391.

A Multicenter, Propensity Score-Matched Assessment of Endoscopic Versus Microscopic Approaches in the Management of Pituitary Adenomas
Findlay M, Drexler R, Khan M, Cole K, Karbe A, Rotermund R, Ricklefs F, Flitsch J, Smith T, Kilgallon J, Honegger J, Nasi-Kordhishti I, Gardner P, Gersey Z, Abdallah H, Jane J, Marino A, Knappe U, Uksul N, Rzaev J, Galushko E, Gormolysova E, Bervitskiy A, Schroeder H, Eördögh M, Losa M, Mortini P, Gerlach R, Antunes A, Couldwell W, Budohoski K, Rennert R, Azab M, Karsy M
NEUROSURGERY. 2023;93(4):794-801.

Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
Genduso S, Freytag V, Schetler D, Kirchner L, Schiecke A, Maar H, Wicklein D, Gebauer F, Bröker K, Stürken C, Milde-Langosch K, Oliveira-Ferrer L, Ricklefs F, Ewald F, Wolters-Eisfeld G, Riecken K, Unrau L, Krause L, Bohnenberger H, Offermann A, Perner S, Sebens S, Lamszus K, Diehl L, Linder S, Jücker M, Schumacher U, Lange T
J HEMATOL ONCOL. 2023;16(1):.

Corticosteroid-Dependent Leukocytosis Masks the Predictive Potential of White Blood Cells for Delayed Cerebral Ischemia and Ventriculoperitoneal Shunt Dependency in Aneurysmatic Subarachnoid Hemorrhage
Piffko A, Ricklefs F, Schweingruber N, Sauvigny T, Mader M, Mohme M, Dührsen L, Westphal M, Regelsberger J, Schmidt N, Czorlich P
J CLIN MED. 2023;12(3):.

Machine learning based outcome prediction of microsurgically treated unruptured intracranial aneurysms
Stroh N, Stefanits H, Maletzky A, Kaltenleithner S, Thumfart S, Giretzlehner M, Drexler R, Ricklefs F, Dührsen L, Aspalter S, Rauch P, Gruber A, Gmeiner M
SCI REP-UK. 2023;13(1):22641.

2022

The Diagnostic Impact of Epigenomics in Pituicyte-derived Tumors: Report of an Unusual Sellar Lesion with Extensive Hemorrhage and Necrotic Debris
Dottermusch M, Rotermund R, Ricklefs F, Wefers A, Saeger W, Flitsch J, Glatzel M, Matschke J
ENDOCR PATHOL. 2022;33(3):411-413.

The Comprehensive Complication Index (CCI) as a Measure of Postoperative Morbidity and Neurological Outcome after Elective Intracranial Surgery
Drexler R, Ricklefs F, Pantel T, Göttsche J, Westphal M, Dührsen L
J NEUROL SURG PART A. 2022 [Epub ahead of print].

Experiences with a 3D4K digital exoscope system (ORBEYE) in a wide range of neurosurgical procedures
Göttsche J, Piffko A, Pantel T, Westphal M, Flitsch J, Ricklefs F, Regelsberger J, Dührsen L
J NEUROL SURG PART A. 2022;83(6):596-601.

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
Krasemann S, Haferkamp U, Pfefferle S, Woo M, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau J, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König E, Bodem J, Franzenburg S, Franke A, Moese S, Müller F, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese M, Glatzel M, Pless O
STEM CELL REP. 2022;17(2):307-320.

Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Ravi V, Will P, Kueckelhaus J, Sun N, Joseph K, Salié H, Vollmer L, Kuliesiute U, von Ehr J, Benotmane J, Neidert N, Follo M, Scherer F, Goeldner J, Behringer S, Franco P, Khiat M, Zhang J, Hofmann U, Fung C, Ricklefs F, Lamszus K, Boerries M, Ku M, Beck J, Sankowski R, Schwabenland M, Prinz M, Schüller U, Killmer S, Bengsch B, Walch A, Delev D, Schnell O, Heiland D
CANCER CELL. 2022;40(6):639-655.e13.

DNA Methylation subclass Receptor Tyrosine Kinase II (RTK II) is predictive for seizure development in glioblastoma patients
Ricklefs F, Drexler R, Wollmann K, Eckhardt A, Heiland D, Sauvigny T, Maire C, Lamszus K, Westphal M, Schüller U, Dührsen L
NEURO-ONCOLOGY. 2022;24(11):1886-1897.

Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas
Ricklefs F, Fita K, Mohme M, Mawrin C, Rahmanzade R, Sahm F, Dührsen L, Göbel C, Lamszus K, Westphal M, Schüller U, Eicker S
ACTA NEUROPATHOL. 2022;144(5):1057-1059.

Diagnostic potential of extracellular vesicles in meningioma patients
Ricklefs F, Maire C, Wollmann K, Dührsen L, Fita K, Sahm F, Herold-Mende C, von Deimling A, Kolbe K, Holz M, Bergmann L, Fuh M, Schlüter H, Alawi M, Reimer R, Sven P, Glatzel M, Westphal M, Lamszus K
NEURO-ONCOLOGY. 2022;24(12):2078-2090.

MPAPASS software enables stitched multiplex, multidimensional EV repertoire analysis and a standard framework for reporting bead-based assays
Welsh J, Killingsworth B, Kepley J, Traynor T, Cook S, Savage J, Marte J, Lee M, Maeng H, Pleet M, Magana S, Gorgens A, Maire C, Lamszus K, Ricklefs F, Merino M, Linehan W, Greten T, Cooks T, Harris C, Apolo A, Abdel-Mageed A, Ivanov A, Trepel J, Roth M, Tkach M, Milosavljevic A, Théry C, LeBlanc A, Berzofsky J, Ruppin E, Aldape K, Camphausen K, Gulley J, Ghiran I, Jacobson S, Jones J
CELL REP METHODS. 2022;2(1):.

Circulating tumor cells and extracellular vesicles as liquid biopsy markers in neuro-oncology: prospects and limitations
Westphal M, Pantel K, Ricklefs F, Maire C, Riethdorf S, Mohme M, Wikman H, Lamszus K
NEURO-ONCOL ADV. 2022;4(Suppl 2):ii45-ii52.

2021

Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry
Drexler R, Ben-Haim S, Bien C, Borger V, Cardinale F, Carpentier A, Cendes F, Chandra S, Clusmann H, Colon A, de Curtis M, Delev D, Didato G, Dührsen L, Farah J, Guenot M, Ghatan S, Haegelen C, Hamer H, Hauptmann J, Jeffree R, Kalbhenn T, Kegele J, Krayenbühl N, Lang J, Mathon B, Naros G, Onken J, Panov F, Raftopoulos C, Ricklefs F, Rijkers K, Rizzi M, Rössler K, Schijns O, Schneider U, Spyrantis A, Strzelczyk A, Stodieck S, Tripathi M, Vadera S, Alonso-Vanegas M, Vaz J, Wellmer J, Wehner T, Westphal M, Sauvigny T
FRONT NEUROL. 2021;12:.

Integrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated
Maas S, Stichel D, Hielscher T, Sievers P, Berghoff A, Schrimpf D, Sill M, Euskirchen P, Blume C, Patel A, Dogan H, Reuss D, Dohmen H, Stein M, Reinhardt A, Suwala A, Wefers A, Baumgarten P, Ricklefs F, Rushing E, Bewerunge-Hudler M, Ketter R, Schittenhelm J, Jaunmuktane Z, Leu S, Greenway F, Bridges L, Jones T, Grady C, Serrano J, Golfinos J, Sen C, Mawrin C, Jungk C, Hänggi D, Westphal M, Lamszus K, Etminan N, Jungwirth G, Herold-Mende C, Unterberg A, Harter P, Wirsching H, Neidert M, Ratliff M, Platten M, Snuderl M, Aldape K, Brandner S, Hench J, Frank S, Pfister S, Jones D, Reifenberger G, Acker T, Wick W, Weller M, Preusser M, von Deimling A, Sahm F
J CLIN ONCOL. 2021;39(34):3839-3852.

Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification
Maire C, Fuh M, Kaulich K, Fita K, Stevic I, Heiland D, Welsh J, Jones J, Görgens A, Ricklefs T, Dührsen L, Sauvigny T, Joosse S, Reifenberger G, Pantel K, Glatzel M, Miklosi A, Felce J, Caselli M, Pereno V, Reimer R, Schlüter H, Westphal M, Schüller U, Lamszus K, Ricklefs F
NEURO-ONCOLOGY. 2021;23(7):1087-1099.

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
Schneider E, Winzer R, Rissiek A, Ricklefs I, Meyer-Schwesinger C, Ricklefs F, Bauche A, Behrends J, Reimer R, Brenna S, Wasielewski H, Lauten M, Rissiek B, Puig B, Cortesi F, Magnus T, Fliegert R, Müller C, Gagliani N, Tolosa E
NAT COMMUN. 2021;12(1):5911.

2020

Decision-making in temporal lobe epilepsy surgery based on invasive stereo-electroencephalography (sEEG)
Dührsen L, Sauvigny T, Ricklefs F, Hamel W, Koeppen J, Hebel J, Lanz M, Martens T
NEUROSURG REV. 2020;43(5):1403-1408.

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
Gupta D, Liang X, Pavlova S, Wiklander O, Corso G, Zhao Y, Saher O, Bost J, Zickler A, Piffko A, Maire C, Ricklefs F, Gustafsson O, Llorente V, Gustafsson M, Bostancioglu B, Mamand D, Hagey D, Görgens A, Nordin J, Andaloussi S
J EXTRACELL VESICLES. 2020.

Immune Escape Mediated by Exosomal PD-L1 in Cancer
Lawler S, Nowicki M, Ricklefs F, Chiocca E
ADV BIOSYST. 2020;4(12):e2000017.

Initial pupil status is a strong predictor for in-hospital mortality after aneurysmal subarachnoid hemorrhage
Mader M, Piffko A, Dengler N, Ricklefs F, Dührsen L, Schmidt N, Regelsberger J, Westphal M, Wolf S, Czorlich P
SCI REP-UK. 2020;10(1):4764.

Genome-wide DNA methylation profiles distinguish silent from non-silent ACTH adenomas
Ricklefs F, Fita K, Rotermund R, Piffko A, Schmid S, Capper D, Buslei R, Buchfelder M, Burkhardt T, Matschke J, Lamszus K, Westphal M, Schüller U, Flitsch J
ACTA NEUROPATHOL. 2020;140(1):95-97.

FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
Ricklefs F, Maire C, Matschke J, Dührsen L, Sauvigny T, Holz M, Kolbe K, Peine S, Herold-Mende C, Carter B, Chiocca E, Lawler S, Westphal M, Lamszus K
INT J MOL SCI. 2020;21(6):.

Features of tumor texture influence surgery and outcome in intracranial meningioma
Sauvigny T, Ricklefs F, Hoffmann L, Schwarz R, Westphal M, Schmidt N
NEURO-ONCOL ADV. 2020;2(1):vdaa113.

Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
Stevic I, Buescher G, Ricklefs F
CELLS-BASEL. 2020;9(1):.

High-Resolution Imaging Flow Cytometry Reveals Impact of Incubation Temperature on Labeling of Extracellular Vesicles with Antibodies
Tertel T, Bremer M, Maire C, Lamszus K, Peine S, Jawad R, Andaloussi S, Giebel B, Ricklefs F, Görgens A
CYTOM PART A. 2020;97(6):602-609.

Mass Spectrometric Lipid Profiles of Picosecond Infrared Laser-Generated Tissue Aerosols Discriminate Different Brain Tissues
Wurlitzer M, Hessling E, Rinas K, Fuh M, Petersen H, Ricklefs F, Lamszus K, Regelsberger J, Maier S, Kruber S, Hansen N, Miller R, Schlüter H
LASER SURG MED. 2020;52(3):228-234.

2019

Seizures as presenting symptom in patients with glioblastoma
Dührsen L, Sauvigny T, Ricklefs F, Mende K, Schaper M, Matschke J, Goebell E, Westphal M, Martens T
EPILEPSIA. 2019;60(1):149-154.

Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence-tagged vesicles as biological reference material
Görgens A, Bremer M, Ferrer-Tur R, Murke F, Tertel T, Horn P, Thalmann S, Welsh J, Probst C, Guerin C, Boulanger C, Jones J, Hanenberg H, Erdbrügger U, Lannigan J, Ricklefs F, El-Andaloussi S, Giebel B
J EXTRACELL VESICLES. 2019;8(1):1587567.

Immune Characterization in Aneurysmal Subarachnoid Hemorrhage Reveals Distinct Monocytic Activation and Chemokine Patterns
Mohme M, Sauvigny T, Mader M, Schweingruber N, Maire C, Rünger A, Ricklefs F, Regelsberger J, Schmidt N, Westphal M, Lamszus K, Tolosa E, Czorlich P
TRANSL STROKE RES. 2019.

Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling
Ricklefs F, Fritzsche F, Winkler B, Meissner B, Dührsen L, Westphal M, Rutkowski S, Martens T, Schüller U
CHILD NERV SYST. 2019;35(6):1029-1033.

Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours
Ricklefs F, Maire C, Reimer R, Dührsen L, Kolbe K, Holz M, Schneider E, Rissiek A, Babayan A, Hille C, Pantel K, Krasemann S, Glatzel M, Heiland D, Flitsch J, Martens T, Schmidt N, Peine S, Breakefield X, Lawler S, Chiocca E, Fehse B, Giebel B, Görgens A, Westphal M, Lamszus K
J EXTRACELL VESICLES. 2019;8(1):1588555.

2018

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles
Ricklefs F, Alayo Q, Krenzlin H, Mahmoud A, Speranza M, Nakashima H, Hayes J, Lee K, Balaj L, Passaro C, Krasemann S, Carter B, Chen C, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield X, Godlweski J, Westphal M, Lamszus K, Freeman G, Bronisz A, Lawler S, Chiocca E
SCI ADV. 2018;4(3):eaar2766.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Théry C, Witwer K, Aikawa E, Alcaraz M, Anderson J, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith G, Ayre D, Bach J, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer N, Baxter A, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi A, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs F, Bosch S, Boulanger C, Breakefield X, Breglio A, Brennan M, Brigstock D, Brisson A, Broekman M, Bromberg J, Bryl-Górecka P, Buch S, Buck A, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás E, Byrd J, Camussi G, Carter D, Caruso S, Chamley L, Chang Y, Chen C, Chen S, Cheng L, Chin A, Clayton A, Clerici S, Cocks A, Cocucci E, Coffey R, Cordeiro-da-Silva A, Couch Y, Coumans F, Coyle B, Crescitelli R, Criado M, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana E, De Wever O, Del Portillo H, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich L, Dolo V, Dominguez Rubio A, Dominici M, Dourado M, Driedonks T, Duarte F, Duncan H, Eichenberger R, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez J, Fatima F, Fish J, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho Y, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan D, Görgens A, Gorski S, Greening D, Gross J, Gualerzi A, Gupta G, Gustafson D, Handberg A, Haraszti R, Harrison P, Hegyesi H, Hendrix A, Hill A, Hochberg F, Hoffmann K, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim A, Ikezu T, Inal J, Isin M, Ivanova A, Jackson H, Jacobsen S, Jay S, Jayachandran M, Jenster G, Jiang L, Johnson S, Jones J, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano S, Kaur S, Kawamura Y, Keller E, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim K, Kislinger T, Klingeborn M, Klinke D, Kornek M, Kosanović M, Kovács Á, Krämer-Albers E, Krasemann S, Krause M, Kurochkin I, Kusuma G, Kuypers S, Laitinen S, Langevin S, Languino L, Lannigan J, Lässer C, Laurent L, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee M, Lee Y, Lemos D, Lenassi M, Leszczynska A, Li I, Liao K, Libregts S, Ligeti E, Lim R, Lim S, Linē A, Linnemannstöns K, Llorente A, Lombard C, Lorenowicz M, Lörincz Á, Lötvall J, Lovett J, Lowry M, Loyer X, Lu Q, Lukomska B, Lunavat T, Maas S, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova E, Martin-Jaular L, Martinez M, Martins V, Mathieu M, Mathivanan S, Maugeri M, McGinnis L, McVey M, Meckes D, Meehan K, Mertens I, Minciacchi V, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth D, Myburgh K, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan J, Nolte-'t Hoen E, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz L, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel D, Peinado H, Perut F, Pfaffl M, Phinney D, Pieters B, Pink R, Pisetsky D, Pogge von Strandmann E, Polakovicova I, Poon I, Powell B, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai R, Raimondo S, Rak J, Ramirez M, Raposo G, Rayyan M, Regev-Rudzki N, Ricklefs F, Robbins P, Roberts D, Rodrigues S, Rohde E, Rome S, Rouschop K, Rughetti A, Russell A, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad J, Saul M, Schiffelers R, Schneider R, Schøyen T, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke G, Shetty A, Shiba K, Siljander P, Silva A, Skowronek A, Snyder O, Soares R, Sódar B, Soekmadji C, Sotillo J, Stahl P, Stoorvogel W, Stott S, Strasser E, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh W, Tomasini R, Torrecilhas A, Tosar J, Toxavidis V, Urbanelli L, Vader P, van Balkom B, van der Grein S, Van Deun J, van Herwijnen M, Van Keuren-Jensen K, van Niel G, van Royen M, van Wijnen A, Vasconcelos M, Vechetti I, Veit T, Vella L, Velot É, Verweij F, Vestad B, Viñas J, Visnovitz T, Vukman K, Wahlgren J, Watson D, Wauben M, Weaver A, Webber J, Weber V, Wehman A, Weiss D, Welsh J, Wendt S, Wheelock A, Wiener Z, Witte L, Wolfram J, Xagorari A, Xander P, Xu J, Yan X, Yáñez-Mó M, Yin H, Yuana Y, Zappulli V, Zarubova J, Žėkas V, Zhang J, Zhao Z, Zheng L, Zheutlin A, Zickler A, Zimmermann P, Zivkovic A, Zocco D, Zuba-Surma E
J EXTRACELL VESICLES. 2018;7(1):1535750.

2017

Impact of dexamethasone in patients with aneurysmal subarachnoid haemorrhage
Czorlich P, Sauvigny T, Ricklefs F, Abboud T, Nierhaus A, Vettorazzi E, Reuter D, Regelsberger J, Westphal M, Schmidt N
EUR J NEUROL. 2017;24(4):645-651.

MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.
Godlewski J, Ferrer-Luna R, Rooj A, Mineo M, Ricklefs F, Takeda Y, Nowicki M, Salinska E, Nakano I, Weissleder R, Beroukhim R, Chiocca E, Bronisz A
STEM CELL REP. 2017;8(6):1497-1505.

MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells
Rooj A, Ricklefs F, Mineo M, Nakano I, Chiocca E, Bronisz A, Godlewski J
CELL REP. 2017;19(10):2026-2032.

2016

The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches
Mineo M, Ricklefs F, Rooj A, Lyons S, Ivanov P, Ansari K, Nakano I, Chiocca E, Godlewski J, Bronisz A
CELL REP. 2016;15(11):2500-9.

Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity
Ricklefs F, Mineo M, Rooj A, Nakano I, Charest A, Weissleder R, Breakefield X, Chiocca E, Godlewski J, Bronisz A
CANCER RES. 2016;76(10):2876-81.

2015

Impact of intraventricular hemorrhage measured by Graeb and LeRoux score on case fatality risk and chronic hydrocephalus in aneurysmal subarachnoid hemorrhage
Czorlich P, Ricklefs F, Reitz M, Vettorazzi E, Abboud T, Regelsberger J, Westphal M, Schmidt N
ACTA NEUROCHIR. 2015;157(3):409-15.

The simplified acute physiology score II to predict hospital mortality in aneurysmal subarachnoid hemorrhage
Czorlich P, Sauvigny T, Ricklefs F, Kluge S, Vettorazzi E, Regelsberger J, Westphal M, Schmidt N
ACTA NEUROCHIR. 2015;157(12):2051-2059.

Letzte Aktualisierung aus dem FIS: 23.12.2024 - 23:36 Uhr