- Facharzt für Neuropathologie
Fachgebiete
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Neuropathologie
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Pädiatrische Hämatologie und Onkologie
Tätigkeitsschwerpunkte
Publikationen
Classification of Brain Tumors by Nanopore Sequencing of Cell-Free DNA from Cerebrospinal Fluid
Afflerbach A, Rohrandt C, Brändl B, Sönksen M, Hench J, Frank S, Börnigen D, Alawi M, Mynarek M, Winkler B, Ricklefs F, Synowitz M, Dührsen L, Rutkowski S, Wefers A, Müller F, Schoof M, Schüller U
CLIN CHEM. 2024;70(1):250-260.
Molecular refinement of pilocytic astrocytoma in adult patients
Bode H, Kresbach C, Holdhof D, Dorostkar M, Harter P, Hench J, Frank S, Suwala A, Schweizer L, Eckhardt A, Neyazi S, Bockmayr M, Wefers A, Schüller U
NEUROPATH APPL NEURO. 2024;50(1):e12949.
40-Year-old man with two asynchronous spinal cord tumors
Bschorer M, Dottermusch M, Matschke J, Gempt J, Schüller U, Mohme M
BRAIN PATHOL. 2024;34(6):e13309.
Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in Embryonal Tumors with Multilayered Rosettes
Dottermusch M, Biabani A, Lempertz T, Schumann Y, Navolic J, Godbole S, Obrecht D, Frank S, Dorostkar M, Voß H, Schlüter H, Rutkowski S, Schüller U, Neumann J
NEURO-ONCOLOGY. 2024;26(5):935-949.
Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features
Dottermusch M, Ryba A, Ricklefs F, Flitsch J, Schmid S, Glatzel M, Saeger W, Neumann J, Schüller U
ACTA NEUROPATHOL. 2024;147(1):16.
Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
Drexler R, Brembach F, Sauvigny J, Ricklefs F, Eckhardt A, Bode H, Gempt J, Lamszus K, Westphal M, Schüller U, Mohme M
ACTA NEUROPATHOL COM. 2024;12(1):9.
A prognostic neural epigenetic signature in high-grade glioma
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Göller P, Sahm F, Menstel J, Zimmer D, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
NAT MED. 2024;30(6):1622-1635.
Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
Drexler R, Khatri R, Schüller U, Eckhardt A, Ryba A, Sauvigny T, Dührsen L, Mohme M, Ricklefs T, Bode H, Hausmann F, Huber T, Bonn S, Voß H, Neumann J, Silverbush D, Hovestadt V, Suvà M, Lamszus K, Gempt J, Westphal M, Heiland D, Hänzelmann S, Ricklefs F
ACTA NEUROPATHOL. 2024;147(1):21.
Applications of Nanopore sequencing in precision cancer medicine
Dyshlovoy S, Paigin S, Afflerbach A, Lobermeyer A, Werner S, Schüller U, Bokemeyer C, Schuh A, Bergmann L, von Amsberg G, Joosse S
INT J CANCER. 2024;155(12):2129-2140.
Mean global DNA methylation serves as independent prognostic marker in IDH wild type glioblastoma
Eckhardt A, Drexler R, Schoof M, Struve N, Capper D, Jelgersma C, Onken J, Harter P, Weber K, Divé I, Rothkamm K, Hoffer K, Klumpp L, Ganser K, Petersen C, Ricklefs F, Kriegs M, Schüller U
NEURO-ONCOLOGY. 2024;26(3):503-513.
Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level
Godbole S, Voß H, Gocke A, Schlumbohm S, Schumann Y, Peng B, Mynarek M, Rutkowski S, Dottermusch M, Dorostkar M, Korshunov A, Mair T, Pfister S, Kwiatkowski M, Hotze M, Neumann P, Hartmann C, Weis J, Liesche-Starnecker F, Guan Y, Moritz M, Siebels B, Struve N, Schlüter H, Schüller U, Krisp C, Neumann J
NAT COMMUN. 2024;15(1):6237.
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
Gödicke S, Kresbach C, Ehlert M, Obrecht D, Altendorf L, Hack K, von Hoff K, Carén H, Melcher V, Kerl K, Englinger B, Filbin M, Pajtler K, Gojo J, Pietsch T, Rutkowski S, Schüller U
ACTA NEUROPATHOL. 2024;147(1):23.
Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma
Körner M, Spohn M, Schüller U, Bockmayr M
ONCOIMMUNOLOGY. 2024;13(1):2386789.
Intraventricular SHH inhibition proves efficient in SHH medulloblastoma mouse model and prevents systemic side effects
Kresbach C, Holst L, Schoof M, Leven T, Göbel C, Neyazi S, Tischendorf J, Loose C, Wrzeszcz A, Yorgan T, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2024;26(4):609-622.
Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
Neyazi S, Yamazawa E, Hack K, Tanaka S, Nagae G, Kresbach C, Umeda T, Eckhardt A, Tatsuno K, Pohl L, Hana T, Bockmayr M, Kim P, Dorostkar M, Takami T, Obrecht D, Takai K, Suwala A, Komori T, Godbole S, Wefers A, Otani R, Neumann J, Higuchi F, Schweizer L, Nakanishi Y, Monoranu C, Takami H, Engertsberger L, Yamada K, Ruf V, Nomura M, Mohme T, Mukasa A, Herms J, Takayanagi S, Mynarek M, Matsuura R, Lamszus K, Ishii K, Kluwe L, Imai H, von Deimling A, Koike T, Benesch M, Kushihara Y, Snuderl M, Nambu S, Frank S, Omura T, Hagel C, Kugasawa K, Mautner V, Ichimura K, Rutkowski S, Aburatani H, Saito N, Schüller U
ACTA NEUROPATHOL. 2024;147(1):22.
Treatment response as surrogate to predict risk for disease progression in pediatric medulloblastoma with persistent magnetic resonance imaging lesions after first-line treatment
Obrecht-Sturm D, Schömig L, Mynarek M, Bison B, Schwarz R, Pietsch T, Pfister S, Sill M, Sturm D, Sahm F, Kortmann R, Gerber N, von Bueren A, Fleischhack G, Schüller U, Nussbaumer G, Benesch M, Rutkowski S
NEURO-ONCOLOGY. 2024;26(9):1712-1722.
Distinct relapse pattern across molecular ependymoma types
Obrecht-Sturm D, Schoof M, Eckhardt A, Mynarek M, Gilbert M, Aldape K, Armstrong T, Ramaswamy V, Bockmayr M, von Hoff K, Fleischhack G, Adolph J, Tippelt S, Pfister S, Pajtler K, Sturm D, Drexler R, Ricklefs F, Stepien N, Gojo J, Pietsch T, Warmuth-Metz M, Kortmann R, Timmermann B, Haberler C, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2024 [Epub ahead of print].
Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas
Pohl L, Leitheiser M, Obrecht D, Schweizer L, Wefers A, Eckhardt A, Raffeld M, Sturm D, Pajtler K, Rutkowski S, Fukuoka K, Ichimura K, Bockmayr M, Schüller U
ACTA NEUROPATHOL. 2024;147(1):24.
Twinning to reduce research and innovation inequalities in paediatric solid tumours across Europe
Rascon J, Blackute R, Cerkauskiene A, Taschner-Mandl S, Andrade N, Planinic A, Rutkowski S, Schüller U, Nysom K, Tuckuviene R, Brok J, Schmiegelow K, van den Heuvel-Eibrink M, van der Perk M, Haupt R, Muraca M, Saraceno D, Geoerger B, Manuzi G, Ladenstein R
EJC Paediatric Oncology. 2024;3:.
Diagnosing intravascular B-cell lymphoma using nanopore sequencing of cell-free DNA from cerebrospinal fluid
Schmidt B, Afflerbach A, Ludewig P, Dirksen P, Paulsen F, Magnus T, Alawi M, Schüller U, Weisel K, Bokemeyer C, Christopeit M
ESMO OPEN. 2024;9(11):103974.
Anaplastic histology and distinct molecular features in a small series of spinal cord ependymomas
Schüller U, Gocke A, Godbole S, Delbridge C, Thomas C, Neumann J
ACTA NEUROPATHOL. 2024;147(1):83.
Morphology-based molecular classification of spinal cord ependymomas using deep neural networks
Schumann Y, Dottermusch M, Schweizer L, Krech M, Lempertz T, Schüller U, Neumann P, Neumann J
BRAIN PATHOL. 2024;34(5):e13239.
Medulloblastoma in children with Fanconi anemia: Association with FA-D1/FA-N, SHH type and poor survival independent of treatment strategies
Sönksen M, Obrecht-Sturm D, Hernáiz Driever P, Sauerbrey A, Graf N, Kontny U, Reimann C, Langhein M, Kordes U, Schwarz R, Obser T, Boschann F, Schüller U, Altendorf L, Goschzik T, Pietsch T, Mynarek M, Rutkowski S
NEURO-ONCOLOGY. 2024;26(11):2125-2139.
Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
Stegat L, Eckhardt A, Gocke A, Neyazi S, Pohl L, Schmid S, Dottermusch M, Frank S, Pinnschmidt H, Herms J, Glatzel M, Snuderl M, Schweizer L, Thomas C, Neumann J, Dorostkar M, Schüller U, Wefers A
ACTA NEUROPATHOL. 2024;148(1):.
G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
Cetin M, Rieckmann T, Hoffer K, Riepen B, Christiansen S, Gatzemeier F, Feyerabend S, Schoof M, Schüller U, Petersen C, Mynarek M, Rothkamm K, Kriegs M, Struve N
RADIAT ONCOL. 2023;18(1):.
Isolated extradural sacrococcygeal ependymoma mimicking teratoma in a 5-year-old boy
Claviez A, Moritz J, Yuan M, Vieth S, Bergholz R, Ahmeti H, Schüller U
KLIN PADIATR. 2023;235(3):185-187.
Unveiling the identities of null cell tumours: Epigenomics corroborate subtle histological cues in pituitary neuroendocrine tumour/adenoma classification
Dottermusch M, Schüller U, Hagel C, Saeger W
NEUROPATH APPL NEURO. 2023;49(1):e12870.
Targeted anticonvulsive treatment of IDH-wildtype glioblastoma based on DNA methylation subclasses
Drexler R, Göttsche J, Sauvigny T, Schüller U, Khatri R, Hausmann F, Hänzelmann S, Huber T, Bonn S, Heiland D, Delev D, Venkataramani V, Winkler F, Weller J, Zeyen T, Herrlinger U, Gempt J, Ricklefs F, Dührsen L
NEURO-ONCOLOGY. 2023;25(5):1006-1008.
Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
bioRxiv. 2023.
Epigenetic profiling reveals a strong association between lack of 5-ALA fluorescence and EGFR amplification in IDH-wildtype glioblastoma
Drexler R, Sauvigny T, Schüller U, Eckhardt A, Maire C, Khatri R, Hausmann F, Hänzelmann S, Huber T, Bonn S, Bode H, Lamszus K, Westphal M, Dührsen L, Ricklefs F
NEURO-ONCOL PRACT. 2023;10(5):462-471.
DNA methylation subclasses predict the benefit from gross total tumor resection in IDH-wildtype glioblastoma patients
Drexler R, Schüller U, Eckhardt A, Filipski K, Hartung T, Harter P, Divé I, Forster M, Czabanka M, Jelgersma C, Onken J, Vajkoczy P, Capper D, Siewert C, Sauvigny T, Lamszus K, Westphal M, Dührsen L, Ricklefs F
NEURO-ONCOLOGY. 2023;25(2):315-325.
Preclinical patient-derived modeling of castration-resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease
Elsesy M, Oh-Hohenhorst S, Oing C, Eckhardt A, Burdak-Rothkamm S, Alawi M, Müller C, Schüller U, Maurer T, von Amsberg G, Petersen C, Rothkamm K, Mansour W
MOL ONCOL. 2023;17(6):1129-1147.
Mitochondrial DNA mutations in Medulloblastoma
Funke V, Sandmann S, Melcher V, Seggewiss J, Horvath J, Jäger N, Kool M, Jones D, Pfister S, Milde T, Rutkowski S, Mynarek M, Varghese J, Sträter R, Rust S, Seelhöfer A, Reunert J, Fiedler B, Schüller U, Marquardt T, Kerl K
ACTA NEUROPATHOL COM. 2023;11(1):124.
Group-specific cellular metabolism in Medulloblastoma
Funke V, Walter C, Melcher V, Wei L, Sandmann S, Hotfilder M, Varghese J, Jäger N, Kool M, Jones D, Pfister S, Milde T, Mynarek M, Rutkowski S, Seggewiss J, Jeising D, de Faria F, Marquardt T, Albert T, Schüller U, Kerl K
J TRANSL MED. 2023;21(1):363.
MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
Göbel C, Godbole S, Schoof M, Holdhof D, Kresbach C, Loose C, Neumann J, Schüller U
ACTA NEUROPATHOL COM. 2023;11(1):174.
Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics
Johann P, Altendorf L, Efremova E, Holsten T, Steinbügl M, Nemes K, Eckhardt A, Kresbach C, Bockmayr M, Koch A, Haberler C, Antonelli M, DeSisto J, Schuhmann M, Hauser P, Siebert R, Bens S, Kool M, Green A, Hasselblatt M, Frühwald M, Schüller U
ACTA NEUROPATHOL. 2023;146(3):527-541.
Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
Keck M, Sill M, Wittmann A, Joshi P, Stichel D, Beck P, Okonechnikow K, Sievers P, Wefers A, Roncaroli F, Avula S, McCabe M, Hayden J, Wesseling P, Øra I, Nistér M, Kranendonk M, Tops B, Zapotocky M, Zamecnik J, Vasiljevic A, Fenouil T, Meyronet D, von Hoff K, Schüller U, Loiseau H, Figarella-Branger D, Kramm C, Sturm D, Scheie D, Rauramaa T, Pesola J, Gojo J, Haberler C, Brandner S, Jacques T, Sexton Oates A, Saffery R, Koscielniak E, Baker S, Yip S, Snuderl M, Ud Din N, Samuel D, Schramm K, Blattner-Johnson M, Selt F, Ecker J, Milde T, von Deimling A, Korshunov A, Perry A, Pfister S, Sahm F, Solomon D, Jones D
ACTA NEUROPATHOL. 2023;145(1):49-69.
Atypical Neurofibromas reveal distinct epigenetic features with proximity to benign peripheral nerve sheath tumor entities
Kresbach C, Dottermusch M, Eckhardt A, Ristow I, Paplomatas P, Altendorf L, Wefers A, Bockmayr M, Belakhoua S, Tran I, Pohl L, Neyazi S, Bode H, Farschtschi S, Well L, Friedrich R, Reuss D, Snuderl M, Hagel C, Mautner V, Schüller U
NEURO-ONCOLOGY. 2023;25(9):1644-1655.
Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts
Mynarek M, Obrecht D, Sill M, Sturm D, Kloth-Stachnau K, Selt F, Ecker J, von Hoff K, Juhnke B, Goschzik T, Pietsch T, Bockmayr M, Kool M, von Deimling A, Witt O, Schüller U, Benesch M, Gerber N, Sahm F, Jones D, Korshunov A, Pfister S, Rutkowski S, Milde T
ACTA NEUROPATHOL. 2023;145(1):97-112.
Generation of new transgenic SMARCA4-deficient mouse models results in neuromuscular weakness and paralysis of limbs
Neyazi S, Altendorf L, Schwetje D, Göbel C, Schoof M, Holdhof D, Schüller U
BRAIN PATHOL. 2023;33(3):e13146.
A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma
Ng C, Obrecht D, Wells O, Zapotocky M, Sumerauer D, Coltin H, Khuong-Quang D, Eisenstat D, Kinross K, White C, Algar E, Luck A, Witt H, Schüller U, Mynarek M, Pietsch T, Gerber N, Benesch M, Warmuth-Metz M, Kortmann R, Bison B, Taylor M, Rutkowski S, Pfister S, Jones D, Gottardo N, von Hoff K, Pajtler K, Ramaswamy V, Hansford J
NEURO-ONCOL ADV. 2023;5(1):vdad057.
hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation
Niesen J, Hermans-Borgmeyer I, Krüger C, Schoof M, Modemann F, Schüller U
ISCIENCE. 2023;26(9):107501.
Kinder und Jugendliche mit intrakraniellem Ependymom – Empfehlungen der HIT-MED-Studiengruppe der GPOH zur Erstlinientherapie
Obrecht D, Mynarek M, Stickan-Verfürth M, Bison B, Schüller U, Pajtler K, Hagel C, Thomale U, Fleischhack G, Timmermann B, Rutkowski S
KLIN PADIATR. 2023;235(3):167-177.
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
Schoof M, Epplen G, Walter C, Ballast A, Holdhof D, Göbel C, Neyazi S, Varghese J, Albert T, Kerl K, Schüller U
ONCOGENESIS. 2023;12(1):36.
Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures
Schoof M, Godbole S, Albert T, Dottermusch M, Walter C, Ballast A, Qin N, Olivera M, Göbel C, Neyazi S, Holdhof D, Kresbach C, Peter L, Epplen G, Thaden V, Spohn M, Blattner-Johnson M, Modemann F, Mynarek M, Rutkowski S, Sill M, Varghese J, Afflerbach A, Eckhardt A, Münter D, Verma A, Struve N, Jones D, Remke M, Neumann J, Kerl K, Schüller U
NAT COMMUN. 2023;14(1):7717.
Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology
Sturm D, Capper D, Andreiuolo F, Gessi M, Kölsche C, Reinhardt A, Sievers P, Wefers A, Ebrahimi A, Suwala A, Gielen G, Sill M, Schrimpf D, Stichel D, Hovestadt V, Daenekas B, Rode A, Hamelmann S, Previti C, Jäger N, Buchhalter I, Blattner-Johnson M, Jones B, Warmuth-Metz M, Bison B, Grund K, Sutter C, Hirsch S, Dikow N, Hasselblatt M, Schüller U, Gerber N, White C, Buntine M, Kinross K, Algar E, Hansford J, Gottardo N, Hernáiz Driever P, Gnekow A, Witt O, Müller H, Calaminus G, Fleischhack G, Kordes U, Mynarek M, Rutkowski S, Frühwald M, Kramm C, von Deimling A, Pietsch T, Sahm F, Pfister S, Jones D
NAT MED. 2023;29(4):917-926.
Risk prediction in early childhood sonic hedgehog medulloblastoma treated with radiation-avoiding chemotherapy
Tonn S, Korshunov A, Obrecht D, Sill M, Spohn M, von Hoff K, Milde T, Pietsch T, Goschzik T, Bison B, Juhnke B, Struve N, Sturm D, Sahm F, Bockmayr M, Friedrich C, von Bueren A, Gerber N, Benesch M, Jones D, Kool M, Wefers A, Schüller U, Pfister S, Rutkowski S, Mynarek M
NEURO-ONCOLOGY. 2023;25(8):1518-1529.
Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment
Träger M, Schweizer L, Pérez E, Schmid S, Hain E, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann D, Dorostkar M, Feyer P, May S, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
NEURO-ONCOLOGY. 2023;25(7):1286-1298.
Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease
Bockmayr M, Harnisch K, Pohl L, Schweizer L, Mohme T, Körner M, Alawi M, Suwala A, Dorostkar M, Monoranu C, Hasselblatt M, Wefers A, Capper D, Hench J, Frank S, Richardson T, Tran I, Liu E, Snuderl M, Engertsberger L, Benesch M, von Deimling A, Obrecht D, Mynarek M, Rutkowski S, Glatzel M, Neumann J, Schüller U
NEURO-ONCOLOGY. 2022;24(10):1689-1699.
Dormant SOX9-positive cells facilitate MYC-driven recurrence of medulloblastoma
Borgenvik A, Holmberg K, Bolin S, Zhao M, Savov V, Rosén G, Hutter S, Garancher A, Suryo Rahmanto A, Bergström T, Olsen T, Mainwaring O, Sattanino D, Verbaan A, Rusert J, Sundstrom A, Ballester Bravo M, Dang Y, Wenz A, Richardson S, Fotaki G, Hill R, Dubuc A, Kalushkova A, Remke M, Cancer M, Jernberg-Wiklund H, Giraud G, Chen X, Taylor M, Sangfelt O, Clifford S, Schüller U, Wechsler-Reya R, Weishaupt H, Swartling F
CANCER RES. 2022;82(24):4586-4603.
Primary central nervous system sarcoma with DICER1 mutation-treatment results of a novel molecular entity in pediatric Peruvian patients
Diaz Coronado R, Mynarek M, Koelsche C, Mora Alferez P, Casavilca Zambrano S, Wachtel Aptowitzer A, Sahm F, von Deimling A, Schüller U, Spohn M, Sturm D, Pfister S, Morales La Madrid A, Sernaque Quintana R, Sarria Bardales G, Negreiros Chinchihuara T, Ojeda Medina L, Garcia-Corrochano Medina P, Campos Sanchez D, Ponce Farfan J, Rutkowski S, Garcia Leon J
CANCER-AM CANCER SOC. 2022;128(4):697-707.
Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors
Graf M, Interlandi M, Moreno N, Holdhof D, Göbel C, Melcher V, Mertins J, Albert T, Kastrati D, Alfert A, Holsten T, de Faria F, Meisterernst M, Rossig C, Warmuth-Metz M, Nowak J, Meyer Zu Hörste G, Mayère C, Nef S, Johann P, Frühwald M, Dugas M, Schüller U, Kerl K
NAT COMMUN. 2022;13(1):.
SMARCB1-deficient and SMARCA4-deficient Malignant Brain Tumors With Complex Copy Number Alterations and TP53 Mutations May Represent the First Clinical Manifestation of Li-Fraumeni Syndrome
Hasselblatt M, Thomas C, Federico A, Nemes K, Johann P, Bison B, Bens S, Dahlum S, Kordes U, Redlich A, Lessel L, Pajtler K, Mawrin C, Schüller U, Nolte K, Kramm C, Hinz F, Sahm F, Giannini C, Penkert J, Kratz C, Pfister S, Siebert R, Paulus W, Kool M, Frühwald M
AM J SURG PATHOL. 2022;46(9):1277-1283.
ALK inhibition as a salvage therapy for a relapsed unclassifiable sarcomatous CNS tumor with EML4/ALK fusion in an infant
Holsten T, Bronsema A, Sturm D, Sahm F, Rutkowski S, Ulrich S, Wößmann W, Kordes U
PEDIATR BLOOD CANCER. 2022;69(8):.
Treatment of embryonal tumors with multilayered rosettes with carboplatin/etoposide induction and high-dose chemotherapy within the prospective P-HIT trial
Juhnke B, Gessi M, Gerber N, Friedrich C, Mynarek M, von Bueren A, Haberler C, Schüller U, Kortmann R, Timmermann B, Bison B, Warmuth-Metz M, Kwiecien R, Pfister S, Spix C, Pietsch T, Kool M, Rutkowski S, von Hoff K
NEURO-ONCOLOGY. 2022;24(1):127-137.
DNA methylation-based classification of sinonasal tumors
Jurmeister P, Glöß S, Roller R, Leitheiser M, Schmid S, Mochmann L, Payá Capilla E, Fritz R, Dittmayer C, Friedrich C, Thieme A, Keyl P, Jarosch A, Schallenberg S, Bläker H, Hoffmann I, Vollbrecht C, Lehmann A, Hummel M, Heim D, Haji M, Harter P, Englert B, Frank S, Hench J, Paulus W, Hasselblatt M, Hartmann W, Dohmen H, Keber U, Jank P, Denkert C, Stadelmann C, Bremmer F, Richter A, Wefers A, Ribbat-Idel J, Perner S, Idel C, Chiariotti L, Della Monica R, Marinelli A, Schüller U, Bockmayr M, Liu J, Lund V, Forster M, Lechner M, Lorenzo-Guerra S, Hermsen M, Johann P, Agaimy A, Seegerer P, Koch A, Heppner F, Pfister S, Jones D, Sill M, von Deimling A, Snuderl M, Müller K, Forgó E, Howitt B, Mertins P, Klauschen F, Capper D
NAT COMMUN. 2022;13(1):.
Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
Kresbach C, Bronsema A, Guerreiro H, Rutkowski S, Schüller U, Winkler B
CHILD NERV SYST. 2022;38(2):479-483.
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond
Kresbach C, Neyazi S, Schüller U
BRAIN PATHOL. 2022;32(4):.
MODL-03. Establishment of intraventricular Shh inhibition as a therapeutic option for young patients with medulloblastoma
Kresbach C, Schoof M, Holst L, Leven T, Yorgan T, Wrzeszcz A, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2022;24(S1):i168.
Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma
Lechner M, Takahashi Y, Turri-Zanoni M, Liu J, Counsell N, Hermsen M, Kaur R, Zhao T, Ramanathan M, Schartinger V, Emanuel O, Helman S, Varghese J, Dudas J, Riechelmann H, Sprung S, Haybaeck J, Howard D, Engel N, Stewart S, Brooks L, Pickles J, Jacques T, Fenton T, Williams L, Vaz F, O'Flynn P, Stimpson P, Wang S, Hannan S, Unadkat S, Hughes J, Dwivedi R, Forde C, Randhawa P, Gane S, Joseph J, Andrews P, Royle G, Franchi A, Maragliano R, Battocchio S, Bewicke-Copley H, Pipinikas C, Webster A, Thirlwell C, Ho D, Teschendorff A, Zhu T, Steele C, Pillay N, Vanhaesebroeck B, Mohyeldin A, Fernandez-Miranda J, Park K, Le Q, West R, Saade R, Manes R, Omay S, Vining E, Judson B, Yarbrough W, Sansovini M, Silvia N, Grassi I, Bongiovanni A, Capper D, Schüller U, Thavaraj S, Sandison A, Surda P, Hopkins C, Ferrari M, Mattavelli D, Rampinelli V, Facchetti F, Nicolai P, Bossi P, Henriquez O, Magliocca K, Solares C, Wise S, Llorente J, Patel Z, Nayak J, Hwang P, Lacy P, Woods R, O'Neill J, Jay A, Carnell D, Forster M, Ishii M, London N, Bell D, Gallia G, Castelnuovo P, Severi S, Lund V, Hanna E
EUR J CANCER. 2022;162:221-236.
Machine Learning Models Predict the Primary Sites of Head and Neck Squamous Cell Carcinoma Metastases Based on DNA Methylation
Leitheiser M, Capper D, Seegerer P, Lehmann A, Schüller U, Müller K, Klauschen F, Jurmeister P, Michael B
J PATHOL. 2022;256(4):378-387.
Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development
Li Q, Han Z, Singh N, Terré B, Fame R, Arif U, Page T, Zahran T, Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov H, Surendran K, Wu L, Virga J, Zhao Y, Ulrich S, Wechsler-Reya R, Lehtinen M, Roy S, Liu Z, Stracker T, Zhao H
CELL DEATH DIFFER. 2022;29(8):1596-1610.
A new amplicon-based gene panel for next generation sequencing characterization of meningiomas
Mawrin C, Koch R, Waldt N, Sandalcioglu I, Braunsdorf W, Warnke J, Goehre F, Meisel H, Ewald C, Neyazi S, Schüller U, Kirches E
BRAIN PATHOL. 2022;32(2):.
Clinical and molecular characterization of isolated M1 disease in pediatric medulloblastoma: experience from the German HIT-MED studies
Obrecht D, Mynarek M, Hagel C, Kwiecien R, Spohn M, Bockmayr M, Bison B, Pfister S, Jones D, Sturm D, von Deimling A, Sahm F, von Hoff K, Juhnke B, Benesch M, Gerber N, Friedrich C, von Bueren A, Kortmann R, Schwarz R, Pietsch T, Fleischhack G, Schüller U, Rutkowski S
J NEURO-ONCOL. 2022;157(1):37-48.
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Ravi V, Will P, Kueckelhaus J, Sun N, Joseph K, Salié H, Vollmer L, Kuliesiute U, von Ehr J, Benotmane J, Neidert N, Follo M, Scherer F, Goeldner J, Behringer S, Franco P, Khiat M, Zhang J, Hofmann U, Fung C, Ricklefs F, Lamszus K, Boerries M, Ku M, Beck J, Sankowski R, Schwabenland M, Prinz M, Schüller U, Killmer S, Bengsch B, Walch A, Delev D, Schnell O, Heiland D
CANCER CELL. 2022;40(6):639-655.e13.
DNA Methylation subclass Receptor Tyrosine Kinase II (RTK II) is predictive for seizure development in glioblastoma patients
Ricklefs F, Drexler R, Wollmann K, Eckhardt A, Heiland D, Sauvigny T, Maire C, Lamszus K, Westphal M, Schüller U, Dührsen L
NEURO-ONCOLOGY. 2022;24(11):1886-1897.
Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas
Ricklefs F, Fita K, Mohme M, Mawrin C, Rahmanzade R, Sahm F, Dührsen L, Göbel C, Lamszus K, Westphal M, Schüller U, Eicker S
ACTA NEUROPATHOL. 2022;144(5):1057-1059.
Increased replication stress and R-loop accumulation in EGFRvIII expressing glioblastoma present new therapeutic opportunities
Struve N, Hoffer K, Weik A, Riepen B, Krug L, Cetin M, Burmester J, Ott L, Liebing J, Gatzemeier F, Müller-Goebel J, Bußmann L, Parplys A, Unger K, Mansour W, Schüller U, Rieckmann T, Petersen C, Rothkamm K, Short S, Kriegs M
NEURO-ONCOL ADV. 2022;4(1):vdab180.
Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies
Adolph J, Fleischhack G, Gaab C, Mikasch R, Mynarek M, Rutkowski S, Schüller U, Pfister S, Pajtler K, Milde T, Witt O, Bison B, Warmuth-Metz M, Kortmann R, Dietzsch S, Pietsch T, Timmermann B, Tippelt S
J NEURO-ONCOL. 2021;155(2):193-202.
Local and Systemic Therapy of Recurrent Ependymoma in Children and Adolescents: Short- and Long-term Results of the E-HIT-REZ 2005 Study
Adolph J, Fleischhack G, Mikasch R, Zeller J, Warmuth-Metz M, Bison B, Mynarek M, Rutkowski S, Schüller U, von Hoff K, Obrecht D, Pietsch T, Pfister S, Pajtler K, Witt O, Witt H, Kortmann R, Timmermann B, Krauß J, Frühwald M, Faldum A, Kwiecien R, Bode U, Tippelt S
NEURO-ONCOLOGY. 2021;23(6):1012-1023.
An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma
Albert T, Interlandi M, Sill M, Graf M, Moreno N, Menck K, Rohlmann A, Melcher V, Korbanka S, Meyer Zu Hörste G, Lautwein T, Frühwald M, Krebs C, Holdhof D, Schoof M, Bleckmann A, Missler M, Dugas M, Schüller U, Jäger N, Pfister S, Kerl K
NEURO-ONCOLOGY. 2021;23(4):586-598.
SMARCA4-deficient rhabdoid tumours show intermediate molecular features between SMARCB1-deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type
Andrianteranagna M, Cyrta J, Masliah-Planchon J, Nemes K, Corsia A, Leruste A, Holdhof D, Kordes U, Orbach D, Corradini N, Entz-Werle N, Pierron G, Castex M, Brouchet A, Weingertner N, Ranchère D, Fréneaux P, Delattre O, Bush J, Leary A, Frühwald M, Schüller U, Servant N, Bourdeaut F
J PATHOL. 2021;255(1):1-15.
Medulloblastoma tumor classification using deep transfer learning with multi-scale EfficientNets
Bengs M, Bockmayr M, Schüller U, Schlaefer A
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2021.
Multi-Scale Input Strategies for Medulloblastoma Tumor Classification using Deep Transfer Learning
Bengs M, Pant S, Bockmayr M, Schüller U, Schlaefer A
Current Directions in Biomedical Engineering. 2021;7(1):.
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma
Bočkaj I, Martini T, de Camargo Magalhães E, Bakker P, Meeuwsen-de Boer T, Armandari I, Meuleman S, Mondria M, Stok C, Kok Y, Bakker B, Wardenaar R, Seiler J, Broekhuis M, van den Bos H, Spierings D, Ringnalda F, Clevers H, Schüller U, van Vugt M, Foijer F, Bruggeman S
PLOS GENET. 2021;17(11):.
Cauda equina paragangliomas express HOXB13
Bockmayr M, Körner M, Schweizer L, Schüller U
NEUROPATH APPL NEURO. 2021;47(6):889-890.
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
DeSisto J, Lucas Jr J, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran Q, Hedges D, Hsu C, Armstrong G, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schüller U, Venkataraman S, Hoffman L, Dorris K, Mulcahy Levy J, Hankinson T, Handler M, Liu A, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker S, Merchant T, Orr B, Green A
NAT COMMUN. 2021;12(1):.
Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma
Dottermusch M, Sumisławski P, Krevet J, Middelkamp M, Voß H, Siebels B, Bartsch H, Sotlar K, Meyer P, Frank S, Korshunov A, Glatzel M, Schüller U, Neumann J
ONCOGENESIS. 2021;10(11):78.
IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract Malignancies: Forty Molecularly Homogenous and Histologically Variable Cases With Favorable Outcome
Glöss S, Jurmeister P, Thieme A, Schmid S, Cai W, Serrette R, Perner S, Ribbat-Idel J, Pagenstecher A, Bläker H, Keber U, Stadelmann C, Zechel S, Johann P, Hasselblatt M, Paulus W, Thomas C, Dohmen H, Baumhoer D, Frank S, Agaimy A, Schüller U, Vasudevaraja V, Snuderl M, Liu C, Pfister D, Jungbluth A, Ghossein R, Xu B, Capper D, Dogan S
AM J SURG PATHOL. 2021;45(9):1190-1204.
Double adenomas of the pituitary reveal distinct lineage markers, copy number alterations, and epigenetic profiles
Hagel C, Schüller U, Flitsch J, Knappe U, Kellner U, Bergmann M, Buslei R, Buchfelder M, Rüdiger T, Herms J, Saeger W
PITUITARY. 2021;24(6):904-913.
Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases
Holdhof D, Johann P, Spohn M, Bockmayr M, Safaei S, Joshi P, Masliah-Planchon J, Ho B, Andrianteranagna M, Bourdeaut F, Huang A, Kool M, Upadhyaya S, Bendel A, Indenbirken D, Foulkes W, Bush J, Creytens D, Kordes U, Frühwald M, Hasselblatt M, Schüller U
ACTA NEUROPATHOL. 2021;141(2):291-301.
Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration
Holdhof D, On J, Schoof M, Göbel C, Schüller U
CEREBELLUM. 2021;20(3):410-419.
Brahma-related gene 1 has time-specific roles during brain and eye development
Holdhof D, Schoof M, Neyazi S, Spohn M, Kresbach C, Göbel C, Hellwig M, Indenbirken D, Moreno N, Kerl K, Schüller U
DEVELOPMENT. 2021;148(10):.
Detailed Clinical and Histopathological Description of 8 Cases of Molecularly Defined CNS Neuroblastomas
Holsten T, Lubieniecki F, Spohn M, Mynarek M, Bison B, Löbel U, Rutkowski S, Schüller U
J NEUROPATH EXP NEUR. 2021;80(1):52-59.
Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas
Kirches E, Sahm F, Korshunov A, Bluecher C, Waldt N, Kropf S, Schrimpf D, Sievers P, Stichel D, Schüller U, Schittenhelm J, Riemenschneider M, Karajannis M, Perry A, Pietsch T, Boekhoff S, Capper D, Beck K, Paramasivam N, Schlesner M, Brastianos P, Müller H, Pfister S, Mawrin C
ACTA NEUROPATHOL. 2021;142(5):873-886.
Sarcoma classification by DNA methylation profiling
Koelsche C, Schrimpf D, Stichel D, Sill M, Sahm F, Reuss D, Blattner M, Worst B, Heilig C, Beck K, Horak P, Kreutzfeldt S, Paff E, Stark S, Johann P, Selt F, Ecker J, Sturm D, Pajtler K, Reinhardt A, Wefers A, Sievers P, Ebrahimi A, Suwala A, Fernández-Klett F, Casalini B, Korshunov A, Hovestadt V, Kommoss F, Kriegsmann M, Schick M, Bewerunge-Hudler M, Milde T, Witt O, Kulozik A, Kool M, Romero-Pérez L, Grünewald T, Kirchner T, Wick W, Platten M, Unterberg A, Uhl M, Abdollahi A, Debus J, Lehner B, Thomas C, Hasselblatt M, Paulus W, Hartmann C, Staszewski O, Prinz M, Hench J, Frank S, Versleijen-Jonkers Y, Weidema M, Mentzel T, Griewank K, de Álava E, Martín J, Gastearena M, Chang K, Low S, Cuevas-Bourdier A, Mittelbronn M, Mynarek M, Rutkowski S, Schüller U, Mautner V, Schittenhelm J, Serrano J, Snuderl M, Büttner R, Klingebiel T, Buslei R, Gessler M, Wesseling P, Dinjens W, Brandner S, Jaunmuktane Z, Lyskjær I, Schirmacher P, Stenzinger A, Brors B, Glimm H, Heining C, Tirado O, Sáinz-Jaspeado M, Mora J, Alonso J, Del Muro X, Moran S, Esteller M, Benhamida J, Ladanyi M, Wardelmann E, Antonescu C, Flanagan A, Dirksen U, Hohenberger P, Baumhoer D, Hartmann W, Vokuhl C, Flucke U, Petersen I, Mechtersheimer G, Capper D, Jones D, Fröhling S, Pfister S, von Deimling A
NAT COMMUN. 2021;12(1):498.
Evidence for a low-penetrant extended phenotype of rhabdoid tumor predisposition syndrome type 1 from a kindred with gain of SMARCB1 exon 6
Kordes U, Mautner V, Oyen F, Hagel C, Hartmann C, Heuser M, Frühwald M, Hasselblatt M, Oehl-Huber K, Siebert R, Schneppenheim R, Schüller U
PEDIATR BLOOD CANCER. 2021;68(10):e29185.
Evidence for a low-penetrant extended phenotype of RTPS1 from a kindred with gain of SMARCB1 exon 6
Kordes U, Mautner V, Oyen F, Hagel C, Hartmann C, Heuser M, Frühwald M, Hasselblatt M, Oehl-Huber K, Siebert R, Schneppenheim R, Schüller U
2021.
Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype
Kresbach C, Dorostkar M, Suwala A, Wefers A, Schweizer L, Engertsberger L, Bison B, Mynarek M, Kloth-Stachnau K, Spohn M, von Deimling A, Benesch M, Hagel C, Mautner V, Rutkowski S, Schüller U
ACTA NEUROPATHOL. 2021;141(6):971-974.
EXTH-70. ESTABLISHMENT OF INTRAVENTRICULAR SHH INHIBITION AS A THERAPEUTIC OPTION IN YOUNG PATIENTS WITH MEDULLOBLASTOMA
Kresbach C, Schoof M, Leven T, Holst L, Yorgan T, Wrzeszcz A, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2021;23(Supplement_6):vi179.
Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification
Maire C, Fuh M, Kaulich K, Fita K, Stevic I, Heiland D, Welsh J, Jones J, Görgens A, Ricklefs T, Dührsen L, Sauvigny T, Joosse S, Reifenberger G, Pantel K, Glatzel M, Miklosi A, Felce J, Caselli M, Pereno V, Reimer R, Schlüter H, Westphal M, Schüller U, Lamszus K, Ricklefs F
NEURO-ONCOLOGY. 2021;23(7):1087-1099.
DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles
Safaei S, Mohme M, Niesen J, Schüller U, Bockmayr M
ONCOIMMUNOLOGY. 2021;10(1):.
Malignant gliomas with H3F3A G34R mutation or MYCN amplification in pediatric patients with Li Fraumeni syndrome
Schoof M, Kordes U, Volk A, Al-Kershi S, Kresbach C, Schüller U
ACTA NEUROPATHOL. 2021;142(3):591-593.
Correction to: Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations
Schüller U, Iglauer P, Dorostkar M, Mawrin C, Herms J, Giese A, Glatzel M, Neumann J
ACTA NEUROPATHOL. 2021;141(4):627.
Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations
Schüller U, Iglauer P, Dorostkar M, Mawrin C, Herms J, Giese A, Glatzel M, Neumann J
ACTA NEUROPATHOL. 2021;141(2):323-325.
Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors
Sievers P, Henneken S, Blume C, Sill M, Schrimpf D, Stichel D, Okonechnikov K, Reuss D, Benzel J, Maaß K, Kool M, Sturm D, Zheng T, Ghasemi D, Kohlhof-Meinecke P, Cruz O, Suñol M, Lavarino C, Ruf V, Boldt H, Pagès M, Pouget C, Schweizer L, Kranendonk M, Akhtar N, Bunkowski S, Stadelmann C, Schüller U, Mueller W, Dohmen H, Acker T, Harter P, Mawrin C, Beschorner R, Brandner S, Snuderl M, Abdullaev Z, Aldape K, Gilbert M, Armstrong T, Ellison D, Capper D, Ichimura K, Reifenberger G, Grundy R, Jabado N, Krskova L, Zapotocky M, Vicha A, Varlet P, Wesseling P, Rutkowski S, Korshunov A, Wick W, Pfister S, Jones D, von Deimling A, Pajtler K, Sahm F
ACTA NEUROPATHOL. 2021;142(5):827-839.
The transcriptional landscape of Shh medulloblastoma
Skowron P, Farooq H, Cavalli F, Morrissy A, Ly M, Hendrikse L, Wang E, Djambazian H, Zhu H, Mungall K, Trinh Q, Zheng T, Dai S, Stucklin A, Vladoiu M, Fong V, Holgado B, Nor C, Wu X, Abd-Rabbo D, Bérubé P, Wang Y, Luu B, Suarez R, Rastan A, Gillmor A, Lee J, Zhang X, Daniels C, Dirks P, Malkin D, Bouffet E, Tabori U, Loukides J, Doz F, Bourdeaut F, Delattre O, Masliah-Planchon J, Ayrault O, Kim S, Meyronet D, Grajkowska W, Carlotti C, de Torres C, Mora J, Eberhart C, Van Meir E, Kumabe T, French P, Kros J, Jabado N, Lach B, Pollack I, Hamilton R, Rao A, Giannini C, Olson J, Bognár L, Klekner A, Zitterbart K, Phillips J, Thompson R, Cooper M, Rubin J, Liau L, Garami M, Hauser P, Li K, Ng H, Poon W, Yancey Gillespie G, Chan J, Jung S, McLendon R, Thompson E, Zagzag D, Vibhakar R, Ra Y, Garre M, Schüller U, Shofuda T, Faria C, López-Aguilar E, Zadeh G, Hui C, Ramaswamy V, Bailey S, Jones S, Mungall A, Moore R, Calarco J, Stein L, Bader G, Reimand J, Ragoussis J, Weiss W, Marra M, Suzuki H, Taylor M
NAT COMMUN. 2021;12(1):1749.
Clinical evidence for a biological effect of epigenetically active decitabine in relapsed or progressive rhabdoid tumors
Steinbügl M, Nemes K, Johann P, Kröncke T, Tüchert S, da Costa M, Ebinger M, Schüller U, Sehested A, Hauser P, Reinhard H, Sumerauer D, Hettmer S, Jakob M, Hasselblatt M, Siebert R, Witt O, Gerss J, Kerl K, Frühwald M
PEDIATR BLOOD CANCER. 2021;68(12):.
Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data
Stichel D, Schrimpf D, Sievers P, Reinhardt A, Suwala A, Sill M, Reuss D, Korshunov A, Casalini B, Sommerkamp A, Ecker J, Selt F, Sturm D, Gnekow A, Koch A, Simon M, Hernáiz Driever P, Schüller U, Capper D, van Tilburg C, Witt O, Milde T, Pfister S, Jones D, von Deimling A, Sahm F, Wefers A
NEUROPATH APPL NEURO. 2021;47(3):406-414.
The genetic landscape of choroid plexus tumors in children and adults
Thomas C, Soschinski P, Zwaig M, Oikonomopoulos S, Okonechnikov K, Pajtler K, Sill M, Schweizer L, Koch A, Neumann J, Schüller U, Sahm F, Rauschenbach L, Keyvani K, Proescholdt M, Riemenschneider M, Segewiß J, Ruckert C, Grauer O, Monoranu C, Lamszus K, Patrizi A, Kordes U, Siebert R, Kool M, Ragoussis J, Foulkes W, Paulus W, Rivera B, Hasselblatt M
NEURO-ONCOLOGY. 2021;23(4):650-660.
TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma
Thomas C, Thierfelder F, Träger M, Soschinski P, Müther M, Edelmann D, Förster A, Geiler C, Kim H, Filipski K, Harter P, Schittenhelm J, Eckert F, Ntoulias G, May S, Stummer W, Onken J, Vajkoczy P, Schüller U, Heppner F, Capper D, Koch A, Kaul D, Paulus W, Hasselblatt M, Schweizer L
ACTA NEUROPATHOL. 2021;141(6):959-970.
Therapeutic implications of improved molecular diagnostics for rare CNS-embryonal tumor entities: results of an international, retrospective study
von Hoff K, Haberler C, Schmitt-Hoffner F, Schepke E, de Rojas T, Jacobs S, Zapotocky M, Sumerauer D, Perek-Polnik M, Dufour C, van Vuurden D, Slavc I, Gojo J, Pickles J, Gerber N, Massimino M, Gil-da-Costa M, Garami M, Kumirova E, Sehested A, Scheie D, Cruz O, Moreno L, Cho J, Zeller B, Bovenschen N, Grotzer M, Alderete D, Snuderl M, Zheludkova O, Golanov A, Okonechnikov K, Mynarek M, Juhnke B, Rutkowski S, Schüller U, Pizer B, Zezschwitz B, Kwiecien R, Wechsung M, Konietschke F, Hwang E, Sturm D, Pfister S, von Deimling A, Rushing E, Ryzhova M, Hauser P, Łastowska M, Wesseling P, Giangaspero F, Hawkins C, Figarella-Branger D, Eberhart C, Burger P, Gessi M, Korshunov A, Jacques T, Capper D, Pietsch T, Kool M
NEURO-ONCOLOGY. 2021;23(9):1597-1611.
Ependymoma relapse goes along with a relatively stable epigenome, but a severely altered tumor morphology
Yang D, Holsten T, Börnigen D, Frank S, Mawrin C, Glatzel M, Schüller U
BRAIN PATHOL. 2021;31(1):33-44.
Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas
Zheng T, Ghasemi D, Okonechnikov K, Korshunov A, Sill M, Maass K, Benites Goncalves da Silva P, Ryzhova M, Gojo J, Stichel D, Arabzade A, Kupp R, Benzel J, Taya S, Adachi T, Shiraishi R, Gerber N, Sturm D, Ecker J, Sievers P, Selt F, Chapman R, Haberler C, Figarella-Branger D, Reifenberger G, Fleischhack G, Rutkowski S, Donson A, Ramaswamy V, Capper D, Ellison D, Herold-Mende C, Schüller U, Brandner S, Driever P, Kros J, Snuderl M, Milde T, Grundy R, Hoshino M, Mack S, Gilbertson R, Jones D, Kool M, von Deimling A, Pfister S, Sahm F, Kawauchi D, Pajtler K
CANCER DISCOV. 2021;11(9):2230-2247.
Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup.
Zin F, Cotter J, Haberler C, Dottermusch M, Neumann J, Schüller U, Schweizer L, Thomas C, Nemes K, Johann P, Kool M, Frühwald M, Paulus W, Judkins A, Hasselblatt M
BRAIN PATHOL. 2021;31(5):e12967.
Treatment response of CNS high-grade neuroepithelial tumors with MN1 alteration
Baroni L, Rugilo C, Lubieniecki F, Sampor C, Freytes C, Nobre L, Hansford J, Malalasekera V, Zapotocky M, Dodgshun A, Martinez O, La Madrid A, Lavarino C, Suñol M, Rutkowski S, Schuller U, Bouffet E, Ramaswamy V, Alderete D
PEDIATR BLOOD CANCER. 2020;67(12):e28627.
Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes
Clarke M, Mackay A, Ismer B, Pickles J, Tatevossian R, Newman S, Bale T, Stoler I, Izquierdo E, Temelso S, Carvalho D, Molinari V, Burford A, Howell L, Virasami A, Fairchild A, Avery A, Chalker J, Kristiansen M, Haupfear K, Dalton J, Orisme W, Wen J, Hubank M, Kurian K, Rowe C, Maybury M, Crosier S, Knipstein J, Schuller U, Kordes U, Kram D, Snuderl M, Bridges L, Martin A, Doey L, Al-Sarraj S, Chandler C, Zebian B, Cairns C, Natrajan R, Boult J, Robinson S, Sill M, Dunkel I, Gilheeney S, Rosenblum M, Hughes D, Proszek P, MacDonald T, Preusser M, Haberler C, Slavc I, Packer R, Ng H, Caspi S, Popovic M, Faganel Kotnik B, Wood M, Baird L, Davare M, Solomon D, Olsen T, Brandal P, Farrell M, Cryan J, Capra M, Karremann M, Schittenhelm J, Schuhmann M, Ebinger M, Dinjens W, Kerl K, Hettmer S, Pietsch T, Andreiuolo F, Driever P, Korshunov A, Hiddingh L, Worst B, Sturm D, Zuckermann M, Witt O, Bloom T, Mitchell C, Miele E, Colafati G, Diomedi-Camassei F, Bailey S, Moore A, Hassall T, Lowis S, Tsoli M, Cowley M, Ziegler D, Karajannis M, Aquilina K, Hargrave D, Carceller F, Marshall L, von Deimling A, Kramm C, Pfister S, Sahm F, Baker S, Mastronuzzi A, Carai A, Vinci M, Capper D, Popov S, Ellison D, Jacques T, Jones D, Jones C
CANCER DISCOV. 2020;10(7):942-963.
Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation
Hellwig M, Merk D, Lutz B, Schüller U
CANCER GENE THER. 2020;27(5):294-300.
hGFAP-Positive Stem Cells Depend on Brg1 for Proper Formation of Cerebral and Cerebellar Structures
Holdhof D, Schoof M, Hellwig M, Holdhof N, Niesen J, Schüller U
CEREB CORTEX. 2020;30(3):1382-1392.
Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance
Melcher V, Graf M, Interlandi M, Moreno N, de Faria F, Kim S, Kastrati D, Korbanka S, Alfert A, Gerß J, Meyer Zu Hörste G, Hartmann W, Frühwald M, Dugas M, Schüller U, Hasselblatt M, Albert T, Kerl K
ACTA NEUROPATHOL. 2020;139(5):913-936.
Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape
Mohme M, Maire C, Schliffke S, Joosse S, Alawi M, Matschke J, Schüller U, Dierlamm J, Martens T, Pantel K, Riethdorf S, Lamszus K, Westphal M
ACTA NEUROPATHOL COM. 2020;8(1):.
Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort
Mynarek M, von Hoff K, Pietsch T, Ottensmeier H, Warmuth-Metz M, Bison B, Pfister S, Korshunov A, Sharma T, Jaeger N, Ryzhova M, Zheludkova O, Golanov A, Rushing E, Hasselblatt M, Koch A, Schüller U, von Deimling A, Sahm F, Sill M, Riemenschneider M, Dohmen H, Monoranu C, Sommer C, Staszewski O, Mawrin C, Schittenhelm J, Brück W, Filipski K, Hartmann C, Meinhardt M, Pietschmann K, Haberler C, Slavc I, Gerber N, Grotzer M, Benesch M, Schlegel P, Deinlein F, von Bueren A, Friedrich C, Juhnke B, Obrecht D, Fleischhack G, Kwiecien R, Faldum A, Kortmann R, Kool M, Rutkowski S
J CLIN ONCOL. 2020;38(18):2028-2040.
Molecular characterization of histopathological ependymoma variants
Neumann J, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, Dorostkar M, Wefers A, Frank S, Monoranu C, Koch A, Witt H, Kool M, Pajtler K, Rutkowski S, Glatzel M, Schüller U
ACTA NEUROPATHOL. 2020;139(2):305-318.
Pik3ca mutations significantly enhance the growth of Shh medulloblastoma and lead to metastatic tumour growth in a novel mouse model
Niesen J, Ohli J, Sedlacik J, Dührsen L, Hellwig M, Spohn M, Holsten T, Schüller U
CANCER LETT. 2020;477:10-18.
Genome-wide DNA methylation profiles distinguish silent from non-silent ACTH adenomas
Ricklefs F, Fita K, Rotermund R, Piffko A, Schmid S, Capper D, Buslei R, Buchfelder M, Burkhardt T, Matschke J, Lamszus K, Westphal M, Schüller U, Flitsch J
ACTA NEUROPATHOL. 2020;140(1):95-97.
An 8-Year-Old Girl with Posterior Fossa Mass
Ruf V, Schöler A, Capper D, Arzberger T, Herms J, Schüller U
BRAIN PATHOL. 2020;30(3):713-714.
The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation
Schoof M, Hellwig M, Harrison L, Holdhof D, Lauffer M, Niesen J, Virdi S, Indenbirken D, Schüller U
EUR J NEUROSCI. 2020;51(11):2219-2235.
EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma
Struve N, Binder Z, Stead L, Brend T, Bagley S, Faulkner C, Ott L, Müller-Goebel J, Weik A, Hoffer K, Krug L, Rieckmann T, Bußmann L, Henze M, Morrissette J, Kurian K, Schüller U, Petersen C, Rothkamm K, O Rourke D, Short S, Kriegs M
ONCOGENE. 2020;39(15):3041-3055.
Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series
Benesch M, Mynarek M, Witt H, Warmuth-Metz M, Pietsch T, Bison B, Pfister S, Pajtler K, Kool M, Schüller U, Pietschmann K, Juhnke B, Tippelt S, Fleischhack G, Schmid I, Kramm C, Vorwerk P, Beilken A, Classen C, Hernáiz Driever P, Kropshofer G, Imschweiler T, Lemmer A, Kortmann R, Rutkowski S, von Hoff K
ONCOLOGIST. 2019;24(9):e921-e929.
Immunologic Profiling of Mutational and Transcriptional Subgroups in Pediatric and Adult High-Grade Gliomas
Bockmayr M, Klauschen F, Maire C, Rutkowski S, Westphal M, Lamszus K, Schüller U, Mohme M
CANCER IMMUNOL RES. 2019;7(9):1401-1411.
Diffuse Glioneuronal tumour with Oligodendroglioma-like features and Nuclear Clusters (DGONC) - a molecularly-defined glioneuronal CNS tumour class displaying recurrent monosomy 14
Deng M, Sill M, Sturm D, Stichel D, Witt H, Ecker J, Wittmann A, Schittenhelm J, Ebinger M, Schuhmann M, Figarella-Branger D, Aronica E, Staszewski O, Preusser M, Haberler C, Lauten M, Schüller U, Hartmann C, Snuderl M, Dunham C, Jabado N, Wesseling P, Deckert M, Keyvani K, Gottardo N, Giangaspero F, von Hoff K, Ellison D, Pietsch T, Herold Mende C, Milde T, Witt O, Kool M, Korshunov A, Wick W, von Deimling A, Pfister S, Jones D, Sahm F
NEUROPATH APPL NEURO. 2019 [Epub ahead of print].
Fatal Myelotoxicity Following Palliative Chemotherapy With Cisplatin and Gemcitabine in a Patient With Stage IV Cholangiocarcinoma Linked to Post Mortem Diagnosis of Fanconi Anemia
Engel N, Schliffke S, Schüller U, Frenzel C, Bokemeyer C, Kubisch C, Lessel D
FRONT ONCOL. 2019;9:420.
TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma
Hellwig M, Lauffer M, Bockmayr M, Spohn M, Merk D, Harrison L, Ahlfeld J, Kitowski A, Neumann J, Ohli J, Holdhof D, Niesen J, Schoof M, Kool M, Kraus C, Zweier C, Holmberg D, Schüller U
ACTA NEUROPATHOL. 2019;137(4):657-673.
Predictive factors associated with ventriculoperitoneal shunting after posterior fossa tumor surgery in children
Helmbold L, Kammler G, Regelsberger J, Fritzsche F, Emami P, Schüller U, Krajewski K
CHILD NERV SYST. 2019;35(5):779-788.
Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA
Hou Y, Pinheiro J, Sahm F, Reuss D, Schrimpf D, Stichel D, Casalini B, Koelsche C, Sievers P, Wefers A, Reinhardt A, Ebrahimi A, Fernández-Klett F, Pusch S, Meier J, Schweizer L, Paulus W, Prinz M, Hartmann C, Plate K, Reifenberger G, Pietsch T, Varlet P, Pagès M, Schüller U, Scheie D, de Stricker K, Frank S, Hench J, Pollo B, Brandner S, Unterberg A, Pfister S, Jones D, Korshunov A, Wick W, Capper D, Blümcke I, von Deimling A, Bertero L
ACTA NEUROPATHOL. 2019;137(5):837-846.
Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases
Jurmeister P, Bockmayr M, Seegerer P, Bockmayr T, Treue D, Montavon G, Vollbrecht C, Arnold A, Teichmann D, Bressem K, Schüller U, von Laffert M, Müller K, Capper D, Klauschen F
SCI TRANSL MED. 2019;11(509):.
Dynamic 18F-FET PET is a powerful imaging biomarker in gadolinium-negative gliomas
Kunz M, Albert N, Unterrainer M, la Fougere C, Egensperger R, Schüller U, Lutz J, Kreth S, Tonn J, Kreth F, Thon N
NEURO-ONCOLOGY. 2019;21(2):274-284.
The molecular landscape of ETMR at diagnosis and relapse
Lambo S, Gröbner S, Rausch T, Waszak S, Schmidt C, Gorthi A, Romero J, Mauermann M, Brabetz S, Krausert S, Buchhalter I, Koster J, Zwijnenburg D, Sill M, Hübner J, Mack N, Schwalm B, Ryzhova M, Hovestadt V, Papillon-Cavanagh S, Chan J, Landgraf P, Ho B, Milde T, Witt O, Ecker J, Sahm F, Sumerauer D, Ellison D, Orr B, Darabi A, Haberler C, Figarella-Branger D, Wesseling P, Schittenhelm J, Remke M, Taylor M, Gil-da-Costa M, Łastowska M, Grajkowska W, Hasselblatt M, Hauser P, Pietsch T, Uro-Coste E, Bourdeaut F, Masliah-Planchon J, Rigau V, Alexandrescu S, Wolf S, Li X, Schüller U, Snuderl M, Karajannis M, Giangaspero F, Jabado N, von Deimling A, Jones D, Korbel J, von Hoff K, Lichter P, Huang A, Bishop A, Pfister S, Korshunov A, Kool M
NATURE. 2019;576(7786):274-280.
Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma
Mastrella G, Hou M, Li M, Stoecklein V, Zdouc N, Volmar M, Miletic H, Reinhard S, Herold-Mende C, Kleber S, Eisenhut K, Gargiulo G, Synowitz M, Vescovi A, Harter P, Penninger J, Wagner E, Mittelbronn M, Bjerkvig R, Hambardzumyan D, Schüller U, Tonn J, Radke J, Glass R, Kälin R
CANCER RES. 2019;79(9):2298-2313.
Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling
Ricklefs F, Fritzsche F, Winkler B, Meissner B, Dührsen L, Westphal M, Rutkowski S, Martens T, Schüller U
CHILD NERV SYST. 2019;35(6):1029-1033.
The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration
Schoof M, Launspach M, Holdhof D, Nguyen L, Engel V, Filser S, Peters F, Immenschuh J, Hellwig M, Niesen J, Mall V, Ertl-Wagner B, Hagel C, Spohn M, Lutz B, Sedlacik J, Indenbirken D, Merk D, Schüller U
ACTA NEUROPATHOL COM. 2019;7(1):199.
Contrast enhancement is a prognostic factor in IDH1/2 mutant, but not in wild-type WHO grade II/III glioma as confirmed by machine learning
Suchorska B, Schüller U, Biczok A, Lenski M, Albert N, Giese A, Kreth F, Ertl-Wagner B, Tonn J, Ingrisch M
EUR J CANCER. 2019;107:15-27.
Identification of Distant Metastases From Recurrent Gliosarcoma Using Whole-Body 18F-FDG PET/CT
Unterrainer M, Ruf V, Cyran C, Brendel M, Thon N, Herms J, Schüller U, Tonn J, Bartenstein P, Albert N
CLIN NUCL MED. 2019;44(11):923-924.
Gliosarcoma Is Driven by Alterations in PI3K/Akt, RAS/MAPK Pathways and Characterized by Collagen Gene Expression Signature
Wojtas B, Gielniewski B, Wojnicki K, Maleszewska M, Mondal S, Nauman P, Grajkowska W, Glass R, Schüller U, Herold-Mende C, Kaminska B
CANCERS. 2019;11(3):.
Subgroup-specific immune and stromal microenvironment in medulloblastoma
Bockmayr M, Mohme M, Klauschen F, Winkler B, Budczies J, Rutkowski S, Schüller U
ONCOIMMUNOLOGY. 2018;7(9):e1462430.
DNA methylation-based reclassification of olfactory neuroblastoma
Capper D, Engel N, Stichel D, Lechner M, Glöss S, Schmid S, Koelsche C, Schrimpf D, Niesen J, Wefers A, Jones D, Sill M, Weigert O, Ligon K, Olar A, Koch A, Forster M, Moran S, Tirado O, Sáinz-Japeado M, Mora J, Esteller M, Alonso J, Del Muro X, Paulus W, Felsberg J, Reifenberger G, Glatzel M, Frank S, Monoranu C, Lund V, von Deimling A, Pfister S, Buslei R, Ribbat-Idel J, Perner S, Gudziol V, Meinhardt M, Schüller U
ACTA NEUROPATHOL. 2018;136(2):255-271.
Correction to: DNA methylation-based reclassification of olfactory neuroblastoma
Capper D, Engel N, Stichel D, Lechner M, Glöss S, Schmid S, Kölsche C, Schrimpf D, Niesen J, Wefers A, Jones D, Sill M, Weigert O, Ligon K, Olar A, Koch A, Forster M, Moran S, Tirado O, Sáinz-Jaspeado M, Mora J, Esteller M, Alonso J, Del Muro X, Paulus W, Felsberg J, Reifenberger G, Glatzel M, Frank S, Monoranu C, Lund V, von Deimling A, Pfister S, Buslei R, Ribbat-Idel J, Perner S, Gudziol V, Meinhardt M, Schüller U
ACTA NEUROPATHOL. 2018;136(3):505.
DNA methylation-based classification of central nervous system tumours
Capper D, Jones D, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss D, Kratz A, Wefers A, Huang K, Pajtler K, Schweizer L, Stichel D, Olar A, Engel N, Lindenberg K, Harter P, Braczynski A, Plate K, Dohmen H, Garvalov B, Coras R, Hölsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez F, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Brück W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hänggi D, Hans V, Rozsnoki S, Hansford J, Kohlhof P, Kristensen B, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, Mühleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo N, Driever P, Kramm C, Müller H, Rutkowski S, von Hoff K, Frühwald M, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu C, Perry A, Jones C, Jacques T, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberger G, Wesseling P, Weller M, Collins V, Blümcke I, Bendszus M, Debus J, Huang A, Jabado N, Northcott P, Paulus W, Gajjar A, Robinson G, Taylor M, Jaunmuktane Z, Ryzhova M, Platten M, Unterberg A, Wick W, Karajannis M, Mittelbronn M, Acker T, Hartmann C, Aldape K, Schüller U, Buslei R, Lichter P, Kool M, Herold-Mende C, Ellison D, Hasselblatt M, Snuderl M, Brandner S, Korshunov A, von Deimling A, Pfister S
NATURE. 2018;555(7697):469-474.
Heterogeneity within the PF-EPN-B ependymoma subgroup
Cavalli F, Hübner J, Sharma T, Luu B, Sill M, Zapotocky M, Mack S, Witt H, Lin T, Shih D, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon R, Lipp E, Gururangan S, Grossbach A, French P, Kros J, van Veelen M, Rao A, Giannini C, Leary S, Jung S, Faria C, Mora J, Schüller U, Alonso M, Chan J, Klekner A, Chambless L, Hwang E, Massimino M, Eberhart C, Karajannis M, Lu B, Liau L, Zollo M, Ferrucci V, Carlotti C, Tirapelli D, Tabori U, Bouffet E, Ryzhova M, Ellison D, Merchant T, Gilbert M, Armstrong T, Korshunov A, Pfister S, Taylor M, Aldape K, Pajtler K, Kool M, Ramaswamy V
ACTA NEUROPATHOL. 2018;136(2):227-237.
Medulloblastoma in adults: A retrospective single institution analysis
Hadi I, Roengvoraphoj O, Niyazi M, Roeder F, Schüller U, Belka C, Nachbichler S
STRAHLENTHER ONKOL. 2018;194(3):225-234.
Germline variants in SMARCB1 and other members of the BAF chromatin-remodeling complex across human disease entities: a meta-analysis
Holsten T, Bens S, Oyen F, Nemes K, Hasselblatt M, Kordes U, Siebert R, Frühwald M, Schneppenheim R, Schüller U
EUR J HUM GENET. 2018;26(8):1083-1093.
Group 3 medulloblastoma in a patient with a GYS2 germline mutation and glycogen storage disease 0a
Holsten T, Tsiakas K, Kordes U, Bison B, Pietsch T, Rutkowski S, Santer R, Schüller U
CHILD NERV SYST. 2018;34(3):581-584.
Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations
Koelsche C, Mynarek M, Schrimpf D, Bertero L, Serrano J, Sahm F, Reuss D, Hou Y, Baumhoer D, Vokuhl C, Flucke U, Petersen I, Brück W, Rutkowski S, Zambrano S, Garcia Leon J, Diaz Coronado R, Gessler M, Tirado O, Mora J, Alonso J, Garcia Del Muro X, Esteller M, Sturm D, Ecker J, Milde T, Pfister S, Korshunov A, Snuderl M, Mechtersheimer G, Schüller U, Jones D, von Deimling A
ACTA NEUROPATHOL. 2018;136(2):327-337.
Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
Merk D, Ohli J, Merk N, Thatikonda V, Morrissy S, Schoof M, Schmid S, Harrison L, Filser S, Ahlfeld J, Erkek S, Raithatha K, Andreska T, Weißhaar M, Launspach M, Neumann J, Shakarami M, Plenker D, Marra M, Li Y, Mungall A, Moore R, Ma Y, Jones S, Lutz B, Ertl-Wagner B, Rossi A, Wagener R, Siebert R, Jung A, Eberhart C, Lach B, Sendtner M, Pfister S, Taylor M, Chavez L, Kool M, Schüller U
DEV CELL. 2018;44(6):709-724.e6.
Integrated analysis of dynamic FET PET/CT parameters, histology, and methylation profiling of 44 gliomas
Röhrich M, Huang K, Schrimpf D, Albert N, Hielscher T, von Deimling A, Schüller U, Dimitrakopoulou-Strauss A, Haberkorn U
EUR J NUCL MED MOL I. 2018;45(9):1573-1584.
Identification of time-to-peak on dynamic 18F-FET-PET as a prognostic marker specifically in IDH1/2 mutant diffuse astrocytoma
Suchorska B, Giese A, Biczok A, Unterrainer M, Weller M, Drexler M, Bartenstein P, Schüller U, Tonn J, Albert N
NEURO-ONCOLOGY. 2018;20(2):279-288.
Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET
Vettermann F, Felsberg J, Reifenberger G, Hasselblatt M, Forbrig R, Berding G, la Fougère C, Galldiks N, Schittenhelm J, Weis J, Albert N, Schüller U
CLIN NUCL MED. 2018;43(12):895-898.
Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
Ahlfeld J, Filser S, Schmidt F, Wefers A, Merk D, Glaß R, Herms J, Schüller U
SCI REP-UK. 2017;7(1):6137.
Pilomatrixoma of the Neck/Shoulder Region Mimicking a Rapidly Growing Neoplasm of Peripheral Nerve Sheath Origin in Neurofibromatosis Type 1
Friedrich R, Schüller U, Hagel C
ANTICANCER RES. 2017;37(12):6907-6910.
ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas
Grausam K, Dooyema S, Bihannic L, Premathilake H, Morrissy A, Forget A, Schaefer A, Gundelach J, Macura S, Maher D, Wang X, Heglin A, Ge X, Zeng E, Puget S, Chandrasekar I, Surendran K, Bram R, Schüller U, Talyor M, Ayrault O, Zhao H
CANCER RES. 2017;77(14):3766-3777.
Ex Vivo Assessment of Coronary Atherosclerotic Plaque by Grating-Based Phase-Contrast Computed Tomography: Correlation With Optical Coherence Tomography
Habbel C, Hetterich H, Willner M, Herzen J, Steigerwald K, Auweter S, Schüller U, Hausleiter J, Massberg S, Reiser M, Pfeiffer F, Saam T, Bamberg F
INVEST RADIOL. 2017;52(4):223-231.
Dark-field imaging in coronary atherosclerosis
Hetterich H, Webber N, Willner M, Herzen J, Birnbacher L, Auweter S, Schüller U, Bamberg F, Notohamiprodjo S, Bartsch H, Wolf J, Marschner M, Pfeiffer F, Reiser M, Saam T
EUR J RADIOL. 2017;94:38-45.
Radiomic Analysis Reveals Prognostic Information in T1-Weighted Baseline Magnetic Resonance Imaging in Patients With Glioblastoma
Ingrisch M, Schneider M, Nörenberg D, Negrao de Figueiredo G, Maier-Hein K, Suchorska B, Schüller U, Albert N, Brückmann H, Reiser M, Tonn J, Ertl-Wagner B
INVEST RADIOL. 2017;52(6):360-366.
Spatial heterogeneity in medulloblastoma
Morrissy A, Cavalli F, Remke M, Ramaswamy V, Shih D, Holgado B, Farooq H, Donovan L, Garzia L, Agnihotri S, Kiehna E, Mercier E, Mayoh C, Papillon-Cavanagh S, Nikbakht H, Gayden T, Torchia J, Picard D, Merino D, Vladoiu M, Luu B, Wu X, Daniels C, Horswell S, Thompson Y, Hovestadt V, Northcott P, Jones D, Peacock J, Wang X, Mack S, Reimand J, Albrecht S, Fontebasso A, Thiessen N, Li Y, Schein J, Lee D, Carlsen R, Mayo M, Tse K, Tam A, Dhalla N, Ally A, Chuah E, Cheng Y, Plettner P, Li H, Corbett R, Wong T, Long W, Loukides J, Buczkowicz P, Hawkins C, Tabori U, Rood B, Myseros J, Packer R, Korshunov A, Lichter P, Kool M, Pfister S, Schüller U, Dirks P, Huang A, Bouffet E, Rutka J, Bader G, Swanton C, Ma Y, Moore R, Mungall A, Majewski J, Jones S, Das S, Malkin D, Jabado N, Marra M, Taylor M
NAT GENET. 2017;49(5):780-788.
Medulloblastoma: experimental models and reality
Neumann J, Swartling F, Schüller U
ACTA NEUROPATHOL. 2017;134(5):679-689.
A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors
Neumann J, Wefers A, Lambo S, Bianchi E, Bockstaller M, Dorostkar M, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider M, Renner-Müller I, Merk D, Shakarami M, Sharma T, Chavez L, Glass R, Chan J, Taketo M, Neumann P, Kool M, Schüller U
NAT MED. 2017;23(10):1191-1202.
Outcome in unresectable glioblastoma: MGMT promoter methylation makes the difference
Thon N, Thorsteinsdottir J, Eigenbrod S, Schüller U, Lutz J, Kreth S, Belka C, Tonn J, Niyazi M, Kreth F
J NEUROL. 2017;264(2):350-358.
K27M midline gliomas display malignant progression by imaging and histology
Vettermann F, Neumann J, Suchorska B, Bartenstein P, Giese A, Dorostkar M, Albert N, Schüller U
NEUROPATH APPL NEURO. 2017;43(5):458-462.
Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum
Wefers A, Lindner S, Schulte J, Schüller U
CEREBELLUM. 2017;16(1):122-131.
Anticalins directed against the fibronectin extra domain B as diagnostic tracers for glioblastomas
Albrecht V, Richter A, Pfeiffer S, Gebauer M, Lindner S, Gieser E, Schüller U, Schichor C, Gildehaus F, Bartenstein P, Tonn J, Skerra A, Glass R
INT J CANCER. 2016;138(5):1269-80.
Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma
Büchel G, Schulte J, Harrison L, Batzke K, Schüller U, Hansen W, Schramm A
ONCOIMMUNOLOGY. 2016;5(5):e1131378.
Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium
Engel N, Neumann J, Ahlfeld J, Wefers A, Merk D, Ohli J, Schüller U
PLOS ONE. 2016;11(11):e0166690.
Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
Fielitz K, Althoff K, De Preter K, Nonnekens J, Ohli J, Elges S, Hartmann W, Klöppel G, Knösel T, Schulte M, Klein-Hitpass L, Beisser D, Reis H, Eyking A, Cario E, Schulte J, Schramm A, Schüller U
ONCOTARGET. 2016;7(46):74415-74426.
AHA classification of coronary and carotid atherosclerotic plaques by grating-based phase-contrast computed tomography
Hetterich H, Webber N, Willner M, Herzen J, Birnbacher L, Hipp A, Marschner M, Auweter S, Habbel C, Schüller U, Bamberg F, Ertl-Wagner B, Pfeiffer F, Saam T
EUR RADIOL. 2016;26(9):3223-33.
Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity
Korshunov A, Capper D, Reuss D, Schrimpf D, Ryzhova M, Hovestadt V, Sturm D, Meyer J, Jones C, Zheludkova O, Kumirova E, Golanov A, Kool M, Schüller U, Mittelbronn M, Hasselblatt M, Schittenhelm J, Reifenberger G, Herold-Mende C, Lichter P, Deimling A, Pfister S, Jones D
ACTA NEUROPATHOL. 2016;131(1):137-46.
Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
Langenfurth A, Gu S, Bautze V, Zhang C, Neumann J, Schüller U, Stock K, Wolf S, Maier A, Mastrella G, Pak A, Cheng H, Kälin R, Holmbeck K, Strotmann J, Kettenmann H, Glass R
SCI REP-UK. 2016;6:32203.
Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells
Li L, Grausam K, Wang J, Lun M, Ohli J, Lidov H, Calicchio M, Zeng E, Salisbury J, Wechsler-Reya R, Lehtinen M, Schüller U, Zhao H
NAT CELL BIOL. 2016;18(4):418-30.
Divergent clonal selection dominates medulloblastoma at recurrence
Morrissy A, Garzia L, Shih D, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli F, Ramaswamy V, Lindsay P, Jelveh S, Donovan L, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall K, Ma Y, Tse K, Zeng T, Shumansky K, Roth A, Shah S, Farooq H, Kijima N, Holgado B, Lee J, Matan-Lithwick S, Liu J, Mack S, Manno A, Michealraj K, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson Y, Wu X, Pugh T, Ally A, Bilenky M, Butterfield Y, Carlsen R, Cheng Y, Chuah E, Corbett R, Dhalla N, He A, Lee D, Li H, Long W, Mayo M, Plettner P, Qian J, Schein J, Tam A, Wong T, Birol I, Zhao Y, Faria C, Pimentel J, Nunes S, Shalaby T, Grotzer M, Pollack I, Hamilton R, Li X, Bendel A, Fults D, Walter A, Kumabe T, Tominaga T, Collins V, Cho Y, Hoffman C, Lyden D, Wisoff J, Garvin J, Stearns D, Massimi L, Schüller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn S, Tirapelli D, Carlotti C, Wheeler H, Hallahan A, Ingram W, MacDonald T, Olson J, Van Meir E, Lee J, Wang K, Kim S, Cho B, Pietsch T, Fleischhack G, Tippelt S, Ra Y, Bailey S, Lindsey J, Clifford S, Eberhart C, Cooper M, Packer R, Massimino M, Garre M, Bartels U, Tabori U, Hawkins C, Dirks P, Bouffet E, Rutka J, Wechsler-Reya R, Weiss W, Collier L, Dupuy A, Korshunov A, Jones D, Kool M, Northcott P, Pfister S, Largaespada D, Mungall A, Moore R, Jabado N, Bader G, Jones S, Malkin D, Marra M, Taylor M
NATURE. 2016;529(7586):351-7.
Distinct Histomorphology in Molecular Subgroups of Glioblastomas in Young Patients
Neumann J, Dorostkar M, Korshunov A, Mawrin C, Koch A, Giese A, Schüller U
J NEUROPATH EXP NEUR. 2016;75(5):408-14.
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis
Ramaswamy V, Hielscher T, Mack S, Lassaletta A, Lin T, Pajtler K, Jones D, Luu B, Cavalli F, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon R, Lipp E, Dunham C, Hukin J, Eisenstat D, Fulton D, van Landeghem F, Santi M, van Veelen M, Van Meir E, Osuka S, Fan X, Muraszko K, Tirapelli D, Oba-Shinjo S, Marie S, Carlotti C, Lee J, Rao A, Giannini C, Faria C, Nunes S, Mora J, Hamilton R, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T, Leary S, Ermoian R, Olson J, Leonard J, Gardner C, Grajkowska W, Chambless L, Cain J, Eberhart C, Ahsan S, Massimino M, Giangaspero F, Buttarelli F, Packer R, Emery L, Yong W, Soto H, Liau L, Everson R, Grossbach A, Shalaby T, Grotzer M, Karajannis M, Zagzag D, Wheeler H, von Hoff K, Alonso M, Tuñon T, Schüller U, Zitterbart K, Sterba J, Chan J, Guzman M, Elbabaa S, Colman H, Dhall G, Fisher P, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro A, Pollack I, Prados M, Robins H, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins C, Rutka J, Dirks P, Pfister S, Merchant T, Gilbert M, Armstrong T, Korshunov A, Ellison D, Taylor M
J CLIN ONCOL. 2016;34(21):2468-77.
Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors
Rivera B, Gayden T, Carrot-Zhang J, Nadaf J, Boshari T, Faury D, Zeinieh M, Blanc R, Burk D, Fahiminiya S, Bareke E, Schüller U, Monoranu C, Sträter R, Kerl K, Niederstadt T, Kurlemann G, Ellezam B, Michalak Z, Thom M, Lockhart P, Leventer R, Ohm M, MacGregor D, Jones D, Karamchandani J, Greenwood C, Berghuis A, Bens S, Siebert R, Zakrzewska M, Liberski P, Zakrzewski K, Sisodiya S, Paulus W, Albrecht S, Hasselblatt M, Jabado N, Foulkes W, Majewski J
ACTA NEUROPATHOL. 2016;131(6):847-63.
Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas
Sahm F, Jakobiec F, Meyer J, Schrimpf D, Eberhart C, Hovestadt V, Capper D, Lambo S, Ryzhova M, Schüller U, Zheludkova O, Kumirova E, Lichter P, Deimling A, Jones D, Pfister S, Kool M, Korshunov A
GENE CHROMOSOME CANC. 2016;55(5):418-27.
Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets
Sahm F, Schrimpf D, Jones D, Meyer J, Kratz A, Reuss D, Capper D, Koelsche C, Korshunov A, Wiestler B, Buchhalter I, Milde T, Selt F, Sturm D, Kool M, Hummel M, Bewerunge-Hudler M, Mawrin C, Schüller U, Jungk C, Wick A, Witt O, Platten M, Herold-Mende C, Unterberg A, Pfister S, Wick W, Deimling A
ACTA NEUROPATHOL. 2016;131(6):903-10.
Somatostatin receptor-targeted radionuclide therapy for progressive meningioma benefit linked to 68Ga-DOTATATE/-TOC uptake
Seystahl K, Stoecklein V, Schüller U, Rushing E, Nicolas G, Schäfer N, Ilhan H, Pangalu A, Weller M, Tonn J, Sommerauer M, Albert N
NEURO-ONCOLOGY. 2016;18(11):1538-1547.
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Sturm D, Orr B, Toprak U, Hovestadt V, Jones D, Capper D, Sill M, Buchhalter I, Northcott P, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen S, Balasubramanian G, Worst B, Pajtler K, Brabetz S, Johann P, Sahm F, Reimand J, Mackay A, Carvalho D, Remke M, Phillips J, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley B, Schniederjan M, Santi M, Buccoliero A, Dahiya S, Kramm C, von Bueren A, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald M, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins V, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann M, Shalaby T, Grotzer M, van Meter T, Monoranu C, Felsberg J, Reifenberger G, Snuderl M, Forrester L, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore A, Taylor M, Jones C, Jabado N, Karajannis M, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister S, Ellison D, Korshunov A, Kool M
CELL. 2016;164(5):1060-72.
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup - a retrospective integrated clinical and molecular analysis
Thompson E, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon R, Bigner D, Lipp E, Perreault S, Cho Y, Grant G, Kim S, Lee J, Rao A, Giannini C, Li K, Ng H, Yao Y, Kumabe T, Tominaga T, Grajkowska W, Perek-Polnik M, Low D, Seow W, Chang K, Mora J, Pollack I, Hamilton R, Leary S, Moore A, Ingram W, Hallahan A, Jouvet A, Fèvre-Montange M, Vasiljevic A, Faure-Conter C, Shofuda T, Kagawa N, Hashimoto N, Jabado N, Weil A, Gayden T, Wataya T, Shalaby T, Grotzer M, Zitterbart K, Sterba J, Kren L, Hortobágyi T, Klekner A, László B, Pócza T, Hauser P, Schüller U, Jung S, Jang W, French P, Kros J, van Veelen M, Massimi L, Leonard J, Rubin J, Vibhakar R, Chambless L, Cooper M, Thompson R, Faria C, Carvalho A, Nunes S, Pimentel J, Fan X, Muraszko K, López-Aguilar E, Lyden D, Garzia L, Shih D, Kijima N, Schneider-Fresenius C, Adamski J, Northcott P, Kool M, Jones D, Chan J, Nikolic A, Garre M, Van Meir E, Osuka S, Olson J, Jahangiri A, Castro B, Gupta N, Weiss W, Moxon-Emre I, Mabbott D, Lassaletta A, Hawkins C, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka J, Korshunov A, Pfister S, Packer R, Ramaswamy V, Taylor M
LANCET ONCOL. 2016;17(4):484-95.
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
Torchia J, Golbourn B, Feng S, Ho K, Sin-Chan P, Vasiljevic A, Norman J, Guilhamon P, Garzia L, Agamez N, Lu M, Chan T, Picard D, de Antonellis P, Khuong-Quang D, Planello A, Zeller C, Barsyte-Lovejoy D, Lafay-Cousin L, Letourneau L, Bourgey M, Yu M, Gendoo D, Dzamba M, Barszczyk M, Medina T, Riemenschneider A, Morrissy A, Ra Y, Ramaswamy V, Remke M, Dunham C, Yip S, Ng H, Lu J, Mehta V, Albrecht S, Pimentel J, Chan J, Somers G, Faria C, Roque L, Fouladi M, Hoffman L, Moore A, Wang Y, Choi S, Hansford J, Catchpoole D, Birks D, Foreman N, Strother D, Klekner A, Bognár L, Garami M, Hauser P, Hortobágyi T, Wilson B, Hukin J, Carret A, Van Meter T, Hwang E, Gajjar A, Chiou S, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat D, Scheinemann K, Fleming A, Johnston D, Michaud J, Zelcer S, Hammond R, Afzal S, Ramsay D, Sirachainan N, Hongeng S, Larbcharoensub N, Grundy R, Lulla R, Fangusaro J, Druker H, Bartels U, Grant R, Malkin D, McGlade C, Nicolaides T, Tihan T, Phillips J, Majewski J, Montpetit A, Bourque G, Bader G, Reddy A, Gillespie G, Warmuth-Metz M, Rutkowski S, Tabori U, Lupien M, Brudno M, Schüller U, Pietsch T, Judkins A, Hawkins C, Bouffet E, Kim S, Dirks P, Taylor M, Erdreich-Epstein A, Arrowsmith C, De Carvalho D, Rutka J, Jabado N, Huang A
CANCER CELL. 2016;30(6):891-908.
Serial 18F-FET PET Imaging of Primarily 18F-FET-Negative Glioma- Does It Make Sense?
Unterrainer M, Schweisthal F, Suchorska B, Wenter V, Schmid-Tannwald C, Fendler W, Schüller U, Bartenstein P, Tonn J, Albert N
J NUCL MED. 2016;57(8):1177-82.
Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease
Zou C, Shi Y, Ohli J, Schüller U, Dorostkar M, Herms J
ACTA NEUROPATHOL. 2016;131(2):235-246.
X-ray phase-contrast computed tomography of human coronary arteries
Hetterich H, Willner M, Habbel C, Herzen J, Hoffmann V, Fill S, Hipp A, Marschner M, Schüller U, Auweter S, Massberg S, Reiser M, Pfeiffer F, Saam T, Bamberg F
INVEST RADIOL. 2015;50(10):686-94.
Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities
Korshunov A, Jakobiec F, Eberhart C, Hovestadt V, Capper D, Jones D, Sturm D, Stagner A, Edward D, Eagle R, Proia A, Koch A, Ryzhova M, Ektova A, Schüller U, Zheludkova O, Lichter P, Deimling A, Pfister S, Kool M
NEUROPATHOLOGY. 2015;35(6):538-44.
Localization of SHH medulloblastoma in mice depends on the age at its initiation
Ohli J, Neumann J, Grammel D, Schüller U
ACTA NEUROPATHOL. 2015;130(2):307-9.
A 59-Year-Old Man with Two Cerebellar Lesions and Disturbed Cerebellar Morphology
Pöschl J, Berger F, Kretzschmar H, Schüller U
BRAIN PATHOL. 2015;25(6):790-1.
Histological subtype of medulloblastoma frequently changes upon recurrence
Pöschl J, Koch A, Schüller U
ACTA NEUROPATHOL. 2015;129(3):459-61.
Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue
Rachinger W, Stoecklein V, Terpolilli N, Haug A, Ertl L, Pöschl J, Schüller U, Schichor C, Thon N, Tonn J
J NUCL MED. 2015;56(3):347-53.
MiR-34a deficiency accelerates medulloblastoma formation in vivo
Thor T, Künkele A, Pajtler K, Wefers A, Stephan H, Mestdagh P, Heukamp L, Hartmann W, Vandesompele J, Sadowski N, Becker L, Garrett L, Hölter S, Horsch M, Calzada-Wack J, Klein-Rodewald T, Racz I, Zimmer A, Beckers J, Neff F, Klopstock T, De Antonellis P, Zollo M, Wurst W, Fuchs H, Gailus-Durner V, Schüller U, Angelis M, Eggert A, Schramm A, Schulte J
INT J CANCER. 2015;136(10):2293-303.
Phase-contrast CT: qualitative and quantitative evaluation of atherosclerotic carotid artery plaque
Hetterich H, Willner M, Fill S, Herzen J, Bamberg F, Hipp A, Schüller U, Adam-Neumair S, Wirth S, Reiser M, Pfeiffer F, Saam T
RADIOLOGY. 2014;271(3):870-8.
The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells
Hütz K, Mejías-Luque R, Farsakova K, Ogris M, Krebs S, Anton M, Vieth M, Schüller U, Schneider M, Blum H, Wagner E, Jung A, Gerhard M
CARCINOGENESIS. 2014;35(4):942-50.
Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1
Kerl K, Moreno N, Holsten T, Ahlfeld J, Mertins J, Hotfilder M, Kool M, Bartelheim K, Schleicher S, Handgretinger R, Schüller U, Meisterernst M, Frühwald M
INT J CANCER. 2014;135(4):989-95.
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
Kool M, Jones D, Jäger N, Northcott P, Pugh T, Hovestadt V, Piro R, Esparza L, Markant S, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, Rausch T, Shih D, Reimand J, Sieber L, Wittmann A, Linke L, Witt H, Weber U, Zapatka M, König R, Beroukhim R, Bergthold G, van Sluis P, Volckmann R, Koster J, Versteeg R, Schmidt S, Wolf S, Lawerenz C, Bartholomae C, von Kalle C, Unterberg A, Herold-Mende C, Hofer S, Kulozik A, Deimling A, Scheurlen W, Felsberg J, Reifenberger G, Hasselblatt M, Crawford J, Grant G, Jabado N, Perry A, Cowdrey C, Croul S, Zadeh G, Korbel J, Doz F, Delattre O, Bader G, McCabe M, Collins V, Kieran M, Cho Y, Pomeroy S, Witt O, Brors B, Taylor M, Schüller U, Korshunov A, Eils R, Wechsler-Reya R, Lichter P, Pfister S
CANCER CELL. 2014;25(3):393-405.
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity
Korshunov A, Sturm D, Ryzhova M, Hovestadt V, Gessi M, Jones D, Remke M, Northcott P, Perry A, Picard D, Rosenblum M, Antonelli M, Aronica E, Schüller U, Hasselblatt M, Woehrer A, Zheludkova O, Kumirova E, Puget S, Taylor M, Giangaspero F, Peter Collins V, Deimling A, Lichter P, Huang A, Pietsch T, Pfister S, Kool M
ACTA NEUROPATHOL. 2014;128(2):279-89.
Loss of Smarc proteins impairs cerebellar development
Moreno N, Schmidt C, Ahlfeld J, Pöschl J, Dittmar S, Pfister S, Kool M, Kerl K, Schüller U
J NEUROSCI. 2014;34(40):13486-91.
Cerebellar cortical lamination and foliation require cyclin A2
Otero J, Kalaszczynska I, Michowski W, Wong M, Gygli P, Gokozan H, Griveau A, Odajima J, Czeisler C, Catacutan F, Murnen A, Schüller U, Sicinski P, Rowitch D
DEV BIOL. 2014;385(2):328-39.
Biopsy findings of symptomatic cerebral X-linked adrenoleucodystrophy and histological differentiation from multiple sclerosis
Pfeifenbring S, von Baumgarten L, Schüller U, Rosewich H, Thal D, Wirtz C, Hecht M, Terpolilli N, Brück W
NEUROPATH APPL NEURO. 2014;40(5):658-61.
Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma
Pöschl J, Bartels M, Ohli J, Bianchi E, Kuteykin-Teplyakov K, Grammel D, Ahlfeld J, Schüller U
ACTA NEUROPATHOL. 2014;127(4):605-7.
Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts
Pöschl J, Stark S, Neumann P, Gröbner S, Kawauchi D, Jones D, Northcott P, Lichter P, Pfister S, Kool M, Schüller U
ACTA NEUROPATHOL. 2014;128(1):123-36.
The transcription factor Cux1 in cerebellar granule cell development and medulloblastoma pathogenesis
Topka S, Glassmann A, Weisheit G, Schüller U, Schilling K
CEREBELLUM. 2014;13(6):698-712.
Sox2 requirement in sonic hedgehog-associated medulloblastoma
Ahlfeld J, Favaro R, Pagella P, Kretzschmar H, Nicolis S, Schüller U
CANCER RES. 2013;73(12):3796-807.
Grating-based X-ray phase-contrast tomography of atherosclerotic plaque at high photon energies
Hetterich H, Fill S, Herzen J, Willner M, Zanette I, Weitkamp T, Rack A, Schüller U, Sadeghi M, Brandl R, Adam-Neumair S, Reiser M, Pfeiffer F, Bamberg F, Saam T
Z MED PHYS. 2013;23(3):194-203.
Constitutive activation of β-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system
Pöschl J, Grammel D, Dorostkar M, Kretzschmar H, Schüller U
DEV BIOL. 2013;374(2):319-32.
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis
Ramaswamy V, Remke M, Bouffet E, Faria C, Perreault S, Cho Y, Shih D, Luu B, Dubuc A, Northcott P, Schüller U, Gururangan S, McLendon R, Bigner D, Fouladi M, Ligon K, Pomeroy S, Dunn S, Triscott J, Jabado N, Fontebasso A, Jones D, Kool M, Karajannis M, Gardner S, Zagzag D, Nunes S, Pimentel J, Mora J, Lipp E, Walter A, Ryzhova M, Zheludkova O, Kumirova E, Alshami J, Croul S, Rutka J, Hawkins C, Tabori U, Codispoti K, Packer R, Pfister S, Korshunov A, Taylor M
LANCET ONCOL. 2013;14(12):1200-7.
Translation of atherosclerotic plaque phase-contrast CT imaging from synchrotron radiation to a conventional lab-based X-ray source
Saam T, Herzen J, Hetterich H, Fill S, Willner M, Stockmar M, Achterhold K, Zanette I, Weitkamp T, Schüller U, Auweter S, Adam-Neumair S, Nikolaou K, Reiser M, Pfeiffer F, Bamberg F
PLOS ONE. 2013;8(9):e73513.
Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischaemia
Sanin V, Heeß C, Kretzschmar H, Schüller U
NEUROPATH APPL NEURO. 2013;39(5):510-8.
ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients
Adam S, Schnell O, Pöschl J, Eigenbrod S, Kretzschmar H, Tonn J, Schüller U
BRAIN PATHOL. 2012;22(6):788-97.
Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas
Bahra M, Kamphues C, Boas-Knoop S, Lippert S, Esendik U, Schüller U, Hartmann W, Waha A, Neuhaus P, Heppner F, Pietsch T, Koch A
PANCREAS. 2012;41(2):222-9.
Proper cerebellar development requires expression of β1-integrin in Bergmann glia, but not in granule neurons.
Frick A, Grammel D, Schmidt F, Pöschl J, Priller M, Pagella P, von Bueren A, André O, Peraud A, Tonn J, Rutkowski S, Rutkowski S, Kretzschmar H, Schüller U
GLIA. 2012;60(5):820-832.
Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.
Grammel D, Warmuth-Metz M, von Bueren A, André O, Kool M, Pietsch T, Kretzschmar H, Rutkowski S, Rutkowski S, Pfister S, Schüller U
ACTA NEUROPATHOL. 2012;123(4):601-614.
Dissecting the genomic complexity underlying medulloblastoma.
Jones D, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho Y, Pugh T, Hovestadt V, Stütz A, Rausch T, Warnatz H, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber U, Wang Q, Lasitschka B, Bartholomae C, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts M, Russell R, Coco S, Tonini G, Schüller U, Hans V, Graf N, Kim Y, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik A, von Deimling A, Witt O, Maass E, Rössler J, Ebinger M, Schuhmann M, Frühwald M, Hasselblatt M, Jabado N, Rutkowski S, von Bueren A, André O, Williamson D, Clifford S, McCabe M, Collins V, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott P, Taylor M, Meyerson M, Pomeroy S, Yaspo M, Korbel J, Korshunov A, Eils R, Pfister S, Lichter P
NATURE. 2012;488(7409):100-105.
LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)
Korshunov A, Ryzhova M, Jones D, Northcott P, van Sluis P, Volckmann R, Koster J, Versteeg R, Cowdrey C, Perry A, Picard D, Rosenblum M, Giangaspero F, Aronica E, Schüller U, Hasselblatt M, Collins V, Deimling A, Lichter P, Huang A, Pfister S, Kool M
ACTA NEUROPATHOL. 2012;124(6):875-81.
Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors
Kraus T, Globisch D, Wagner M, Eigenbrod S, Widmann D, Münzel M, Müller M, Pfaffeneder T, Hackner B, Feiden W, Schüller U, Carell T, Kretzschmar H
INT J CANCER. 2012;131(7):1577-90.
Letter to the editor
Schnell O, Pöschl J, Tonn J, Schüller U
BRAIN PATHOL. 2012;22(5):724.
A young man with symptomatic epilepsy and right hemianopia: family affair
von Baumgarten L, Pfeifenbring S, Terpolilli N, Schüller U, Jahn K, Opherk C, Freilinger T
NEUROLOGY. 2012;79(19):2008-9.
Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors
Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar H, Schüller U
MOL CELL BIOL. 2011;31(16):3326-38.
Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans.
Pöschl J, Lorenz A, Hartmann W, von Bueren A, Kool M, Li S, Peraud A, Tonn J, Herms J, Xiang M, Rutkowski S, Kretzschmar H, Schüller U
ONCOGENE. 2011;30(47):4721-4730.
Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients
Priller M, Pöschl J, Abrão L, von Bueren A, Cho Y, Rutkowski S, Kretzschmar H, Schüller U
CLIN CANCER RES. 2011;17(21):6791-801.
A FOXO-Pak1 transcriptional pathway controls neuronal polarity
de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih D, Rowitch D, Brunet A, Bonni A
GENE DEV. 2010;24(8):799-813.
Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma
Heine V, Priller M, Ling J, Rowitch D, Schüller U
CANCER RES. 2010;70(13):5220-5.
Subacute herpes simplex encephalitis presenting as relapsing encephalitis
Peters N, Fesl G, Theil D, Schüller U, Birnbaum T, Brückmann H, Noachtar S
J NEUROL. 2010;257(5):843-5.
Giant cell arteritis of the Basal cerebral arteries: correlation of MRI, dsa, and histopathology
Pfefferkorn T, Schüller U, Cyran C, Hüfner K, Fesl G, Seelos K, Dichgans M, Pfister H, Nikolaou K, Kretzschmar H, Saam T
NEUROLOGY. 2010;74(20):1651-3.
A 76-year-old woman with paraplegia
Rémi J, Pfefferkorn T, König F, Lassmann H, Brück W, Holtmannspötter M, Straube A, Kretzschmar H, Schüller U
BRAIN PATHOL. 2010;20(2):507-10.
Neue Aspekte der MRT-Bildgebung zur Diagnostik der Großgefäßvaskulitiden sowie der primären Angiitis des zentralen Nervensystems
Saam T, Habs M, Cyran C, Grimm J, Pfefferkorn T, Schüller U, Reiser M, Nikolaou K
RADIOLOGE. 2010;50(10):861-71.
Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas
Sutter R, Shakhova O, Bhagat H, Behesti H, Sutter C, Penkar S, Santuccione A, Bernays R, Heppner F, Schüller U, Grotzer M, Moch H, Schraml P, Marino S
ONCOGENE. 2010;29(12):1845-56.
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
Schüller U, Heine V, Mao J, Kho A, Dillon A, Han Y, Huillard E, Sun T, Ligon A, Qian Y, Ma Q, Alvarez-Buylla A, McMahon A, Rowitch D, Ligon K
CANCER CELL. 2008;14(2):123-34.
Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas
Schüller U, Ruiter M, Herms J, Kretzschmar H, Grasbon-Frodl E
ACTA NEUROPATHOL. 2008;115(3):367-8.
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
Yang Z, Ellis T, Markant S, Read T, Kessler J, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch D, Wainwright B, Wechsler-Reya R
CANCER CELL. 2008;14(2):135-45.
Plexin-B2 controls the development of cerebellar granule cells
Friedel R, Kerjan G, Rayburn H, Schüller U, Sotelo C, Tessier-Lavigne M, Chédotal A
J NEUROSCI. 2007;27(14):3921-32.
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas
Koch A, Hrychyk A, Hartmann W, Waha A, Mikeska T, Waha A, Schüller U, Sörensen N, Berthold F, Goodyer C, Wiestler O, Birchmeier W, Behrens J, Pietsch T
INT J CANCER. 2007;121(2):284-91.
Beta-catenin function is required for cerebellar morphogenesis
Schüller U, Rowitch D
BRAIN RES. 2007;1140:161-9.
Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors
Schüller U, Zhao Q, Godinho S, Heine V, Medema R, Pellman D, Rowitch D
MOL CELL BIOL. 2007;27(23):8259-70.
Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis
Schüller U, Kho A, Zhao Q, Ma Q, Rowitch D
MOL CELL NEUROSCI. 2006;33(3):247-59.
Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells
Hartmann W, Koch A, Brune H, Waha A, Schüller U, Dani I, Denkhaus D, Langmann W, Bode U, Wiestler O, Schilling K, Pietsch T
AM J PATHOL. 2005;166(4):1153-62.
Elevated expression of Wnt antagonists is a common event in hepatoblastomas
Koch A, Waha A, Hartmann W, Hrychyk A, Schüller U, Waha A, Wharton K, Fuchs S, von Schweinitz D, Pietsch T
CLIN CANCER RES. 2005;11(12):4295-304.
Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas
Schüller U, Koch A, Hartmann W, Garrè M, Goodyer C, Cama A, Sörensen N, Wiestler O, Pietsch T
INT J CANCER. 2005;117(1):82-9.
Bcl-2 expression inversely correlates with tumour cell differentiation in medulloblastoma
Schüller U, Schober F, Kretzschmar H, Herms J
NEUROPATH APPL NEURO. 2004;30(5):513-21.
Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex
Schüller U, Lamp E, Schilling M
HISTOCHEM CELL BIOL. 2001;116(2):149-59.
Letzte Aktualisierung aus dem FIS: 23.12.2024 - 23:34 Uhr