Time-resolved role of P2X4 and P2X7 during CD8+ T cell activation
Brock V, Lory N, Möckl F, Birus M, Stähler T, Woelk L, Jaeckstein M, Heeren J, Koch-Nolte F, Rissiek B, Mittrücker H, Guse A, Werner R, Diercks B
FRONT IMMUNOL. 2024;15:1258119.

Generation of nanobodies from transgenic 'LamaMice' lacking an endogenous immunoglobulin repertoire
Eden T, Schaffrath A, Wesolowski J, Stähler T, Tode N, Richter N, Schäfer W, Hambach J, Hermans-Borgmeyer I, Woens J, Le Gall C, Wendler S, Linke-Winnebeck C, Stobbe M, Budnicki I, Wanney A, Heitz Y, Schimmelpfennig L, Schweitzer L, Zimmer D, Stahl E, Seyfried F, Gebhardt A, Dieckow L, Riecken K, Fehse B, Bannas P, Magnus T, Verdoes M, Figdor C, Hartlepp K, Schleer H, Füner J, Tomas N, Haag F, Rissiek B, Mann A, Menzel S, Koch-Nolte F
NAT COMMUN. 2024;15(1):4728.

Generation and characterization of antagonistic anti-human CD39 nanobodies
Menzel S, Duan Y, Hambach J, Albrecht B, Wendt-Cousin D, Winzer R, Tolosa E, Rissiek A, Guse A, Haag F, Magnus T, Koch-Nolte F, Rissiek B
FRONT IMMUNOL. 2024;15:1328306.

Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction
Sierra-Marquez J, Schaller L, Sassenbach L, Ramírez-Fernández A, Alt P, Rissiek B, Zimmer B, Schredelseker J, Hector J, Stähler T, Koch-Nolte F, Staab-Weijnitz C, Dietrich A, Kopp R, Nicke A
FRONT IMMUNOL. 2024;15:1425938.

Microglia targeting by adeno-associated viral vectors
Stamataki M, Rissiek B, Magnus T, Körbelin J
FRONT IMMUNOL. 2024;15:1425892.

Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system-No evidence for the role of neuronal P2X7 receptors in colitis
Jooss T, Zhang J, Zimmer B, Rezzonico-Jost T, Rissiek B, Felipe Pelczar P, Seehusen F, Koch-Nolte F, Magnus T, Zierler S, Huber S, Schemann M, Grassi F, Nicke A
MUCOSAL IMMUNOL. 2023;16(2):180-193.

Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis
Montilla A, Zabala A, Er-Lukowiak M, Rissiek B, Magnus T, Rodriguez-Iglesias N, Sierra A, Matute C, Domercq M
CELL DEATH DIS. 2023;14(1):16.

The role of the ATP-adenosine axis in ischemic stroke
Schädlich I, Winzer R, Stabernack J, Tolosa E, Magnus T, Rissiek B
SEMIN IMMUNOPATHOL. 2023;45(3):347-365.

P2X4 and P2X7 are essential players in basal T cell activity and Ca2+ signaling milliseconds after T cell activation
Brock V, Wolf I, Er-Lukowiak M, Lory N, Stähler T, Woelk L, Mittrücker H, Müller C, Koch-Nolte F, Rissiek B, Werner R, Guse A, Diercks B
SCI ADV. 2022;8(5):.

Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo
Demeules M, Scarpitta A, Hardet R, Gondé H, Abad C, Blandin M, Menzel S, Duan Y, Rissiek B, Magnus T, Mann A, Koch-Nolte F, Adriouch S
FRONT IMMUNOL. 2022;13:.

CD38-specific nanobodies allow in vivo imaging of multiple myeloma under daratumumab therapy
Pape L, Hambach J, Gebhardt A, Rissiek B, Stähler T, Tode N, Khan C, Weisel K, Adam G, Koch-Nolte F, Bannas P
FRONT IMMUNOL. 2022;13:.

Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs
Pinto-Espinoza C, Guillou C, Rissiek B, Wilmes M, Javidi E, Schwarz N, Junge M, Haag F, Liaukouskaya N, Wanner N, Nicke A, Stortelers C, Tan Y, Adriouch S, Magnus T, Koch-Nolte F
FRONT PHARMACOL. 2022;13:.

Nt5e deficiency does not affect post-stroke inflammation and lesion size in a murine ischemia/reperfusion stroke model
Schädlich I, Schnapauff O, Pöls L, Schrader J, Tolosa E, Rissiek B, Magnus T
ISCIENCE. 2022;25(6):.

Origin, distribution, and function of three frequent coding polymorphisms in the gene for the human P2X7 ion channel
Schäfer W, Stähler T, Pinto Espinoza C, Danquah W, Knop J, Rissiek B, Haag F, Koch-Nolte F
FRONT PHARMACOL. 2022;13:.

Real-Time Flow Cytometry as a Tool to Monitor Cellular Consequences of P2X7 Activation in Multiple Cell Populations Mixed in a Single FACS Tube
Veltkamp A, Magnus T, Rissiek B
2022. The P2X7 Receptor. Nicke A (Hrsg.). 1. Aufl. New York, NY: HUMANA PRESS INC, 291-302.

Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions
Wilmes M, Pinto Espinoza C, Ludewig P, Stabernack J, Liesz A, Nicke A, Gelderblom M, Gerloff C, Falzoni S, Tolosa E, Di Virgilio F, Rissiek B, Plesnilla N, Koch-Nolte F, Magnus T
J NEUROINFLAMM. 2022;19(1):.

P2X7 is expressed on human innate-like T lymphocytes and mediates susceptibility to ATP-induced cell death
Winzer R, Serracant-Prat A, Brock V, Pinto-Espinoza C, Rissiek B, Amadi M, Eich N, Rissiek A, Schneider E, Magnus T, Guse A, Diercks B, Koch-Nolte F, Tolosa E
EUR J IMMUNOL. 2022;52(11):1805-1818.

Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation
Kumashie K, Cebula M, Hagedorn C, Kreppel F, Pils M, Koch-Nolte F, Rissiek B, Wirth D
FRONT IMMUNOL. 2021;11:.

Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation
Leutert M, Duan Y, Winzer R, Menzel S, Tolosa E, Magnus T, Hottiger M, Koch-Nolte F, Rissiek B
FRONT IMMUNOL. 2021;12:703719.

ADP-Ribosylation Regulates the Signaling Function of IFN-γ
Menzel S, Koudelka T, Rissiek B, Haag F, Meyer-Schwesinger C, Tholey A, Koch-Nolte F
FRONT IMMUNOL. 2021;12:642545.

Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response
Piepke M, Clausen B, Ludewig P, Vienhues J, Bedke T, Javidi E, Rissiek B, Jank L, Brockmann L, Sandrock I, Degenhardt K, Jander A, Roth V, Schädlich I, Prinz I, Flavell R, Kobayashi Y, Renné T, Gerloff C, Huber S, Magnus T, Gelderblom M
J NEUROINFLAMM. 2021;18(1):.

Editorial: The Versatile Role of Nicotinamide Adenine Dinucleotide in Immunity
Rissiek B, Guse A, Adriouch S, Bruzzone S
FRONT IMMUNOL. 2021;12:810280.

Comment on “Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes”
Rissiek B, Heeren J, Koch-Nolte F, Mittrücker H, Magnus T
J IMMUNOL. 2021;206(4):.

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
Schneider E, Winzer R, Rissiek A, Ricklefs I, Meyer-Schwesinger C, Ricklefs F, Bauche A, Behrends J, Reimer R, Brenna S, Wasielewski H, Lauten M, Rissiek B, Puig B, Cortesi F, Magnus T, Fliegert R, Müller C, Gagliani N, Tolosa E
NAT COMMUN. 2021;12(1):5911.

Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake
Brenna S, Altmeppen H, Mohammadi B, Rissiek B, Schlink F, Ludewig P, Krisp C, Schlüter H, Failla A, Schneider C, Glatzel M, Puig B, Magnus T
J EXTRACELL VESICLES. 2020;9(1):1809065.

Circulating Endothelial Cells as Promising Biomarkers in the Differential Diagnosis of Primary Angiitis of the Central Nervous System
Deb-Chatterji M, Pinnschmidt H, Duan Y, Haeussler V, Rissiek B, Gerloff C, Thomalla G, Magnus T
FRONT NEUROL. 2020;11:205.

A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice
Er-Lukowiak M, Duan Y, Rassendren F, Ulmann L, Nicke A, Ufer F, Friese M, Koch-Nolte F, Magnus T, Rissiek B
ISCIENCE. 2020;23(12):101870.

Intravenous Immunoglobulin (IVIg) Induce a Protective Phenotype in Microglia Preventing Neuronal Cell Death in Ischaemic Stroke
Häußler V, Daehn T, Rissiek B, Roth V, Gerloff C, Arumugam T, Magnus T, Gelderblom M
NEUROMOL MED. 2020;22(1):121-132.

Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model
Ramírez-Fernández A, Urbina-Treviño L, Conte G, Alves M, Rissiek B, Durner A, Scalbert N, Zhang J, Magnus T, Koch-Nolte F, Plesnila N, Deussing J, Engel T, Kopp R, Nicke A
SCI REP-UK. 2020;10(1):19876.

Astrocytes and Microglia Are Resistant to NAD+-Mediated Cell Death Along the ARTC2/P2X7 Axis
Rissiek B, Stabernack J, Cordes M, Duan Y, Behr S, Menzel S, Magnus T, Koch-Nolte F
FRONT MOL NEUROSCI. 2020;12:330.

Nanobody-based CD38-specific heavy chain antibodies induce killing of multiple myeloma and other hematological malignancies
Schriewer L, Schütze K, Petry K, Hambach J, Fumey W, Koenigsdorf J, Baum N, Menzel S, Rissiek B, Riecken K, Fehse B, Röckendorf J, Schmid J, Albrecht B, Pinnschmidt H, Ayuk F, Kröger N, Binder M, Schuch G, Hansen T, Haag F, Adam G, Koch-Nolte F, Bannas P
THERANOSTICS. 2020;10(6):2645-2658.

Generation and Characterization of Specific Monoclonal Antibodies and Nanobodies Directed Against the ATP-Gated Channel P2X4
Bergmann P, Garcia de Paco E, Rissiek B, Menzel S, Dubberke G, Hua J, Rassendren F, Ulmann L, Koch-Nolte F
FRONT CELL NEUROSCI. 2019;13:498.

Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy
Jank L, Pinto-Espinoza C, Duan Y, Koch-Nolte F, Magnus T, Rissiek B
ANTIBODIES. 2019.

Generation and Function of Non-cell-bound CD73 in Inflammation
Schneider E, Rissiek A, Winzer R, Puig B, Rissiek B, Haag F, Mittrücker H, Magnus T, Tolosa E
FRONT IMMUNOL. 2019;10:1729.

IL-23 (Interleukin-23)-Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke
Gelderblom M, Gallizioli M, Ludewig P, Thom V, Arunachalam P, Rissiek B, Bernreuther C, Glatzel M, Korn T, Arumugam T, Sedlacik J, Gerloff C, Tolosa E, Planas A, Magnus T
STROKE. 2018;49(1):155-164.

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody
Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A
ELIFE. 2018;7:e36217.

Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme
Leutert M, Menzel S, Braren R, Rissiek B, Hopp A, Nowak K, Bisceglie L, Gehrig P, Li H, Zolkiewska A, Koch-Nolte F, Hottiger M
CELL REP. 2018;24(7):1916-1929.e5.

Monitoring the Sensitivity of T Cell Populations Towards NAD Released During Cell Preparation
Rissiek B, Lukowiak M, Haag F, Magnus T, Koch-Nolte F
2018. ADP-RIBOSYLATION AND NAD+ UTILIZING ENZYMES: METHODS AND PROTOCOLS . Chang P (Hrsg.). 1. Aufl. HUMANA PRESS INC, 317-326.

In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells
Rissiek B, Lukowiak M, Raczkowski F, Magnus T, Mittrücker H, Koch-Nolte F
FRONT IMMUNOL. 2018;9:1580.

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
Zabala A, Vazquez-Villoldo N, Rissiek B, Gejo J, Martin A, Palomino A, Perez-Samartín A, Pulagam K, Lukowiak M, Capetillo-Zarate E, Llop J, Magnus T, Koch-Nolte F, Rassendren F, Matute C, Domercq M
EMBO MOL MED. 2018;10(8):UNSP e8743.

Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia
Adesso S, Magnus T, Cuzzocrea S, Campolo M, Rissiek B, Paciello O, Autore G, Pinto A, Marzocco S
FRONT PHARMACOL. 2017;8:370.

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia
Rissiek B, Menzel S, Leutert M, Cordes M, Behr S, Jank L, Ludewig P, Gelderblom M, Rissiek A, Adriouch S, Haag F, Hottiger M, Koch-Nolte F, Magnus T
SCI REP-UK. 2017;7(1):16477.

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop J, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Nolte F
SCI TRANSL MED. 2016;8(366):366ra162.

Liver-Resident Memory CD8(+) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection
Fernandez-Ruiz D, Ng W, Holz L, Ma J, Zaid A, Wong Y, Lau L, Mollard V, Cozijnsen A, Collins N, Li J, Davey G, Kato Y, Devi S, Skandari R, Pauley M, Manton J, Godfrey D, Braun A, Tay S, Tan P, Bowen D, Nolte F, Rissiek B, Carbone F, Crabb B, Lahoud M, Cockburn I, Mueller S, Bertolino P, McFadden G, Caminschi I, Heath W
IMMUNITY. 2016;45(4):889-902.

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy
Bannas P, Lenz A, Kunick V, Fumey W, Rissiek B, Schmid J, Haag F, Leingärtner A, Trepel M, Adam G, Koch-Nolte F
JOVE-J VIS EXP. 2015;(98):52462.

Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection
Bannas P, Lenz A, Kunick V, Well L, Fumey W, Rissiek B, Haag F, Schmid J, Schütze K, Eichhoff A, Trepel M, Adam G, Ittrich H, Koch-Nolte F
CONTRAST MEDIA MOL I. 2015;10(5):367-378.

Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2
Menzel S, Rissiek B, Bannas P, Jakoby T, Miksiewicz M, Schwarz N, Nissen M, Haag F, Tholey A, Nolte F
J IMMUNOL. 2015;195(5):2057-2066.

ADP-Ribosylation of P2X7 - A Matter of Life and Death for Regulatory T Cells and Natural Killer T Cells
Rissiek B, Haag F, Boyer O, Nolte F, Adriouch S
CURR TOP MICROBIOL. 2015;384:107-126.

P2X7 on Mouse T Cells: One Channel, Many Functions
Rissiek B, Haag F, Boyer O, Nolte F, Adriouch S
FRONT IMMUNOL. 2015;6:204.

Tuning IL-2 signaling by ADP-ribosylation of CD25
Teege S, Hann A, Miksiewicz M, MacMillan C, Rissiek B, Buck F, Menzel S, Nissen M, Bannas P, Haag F, Boyer O, Seman M, Adriouch S, Nolte F
SCI REP-UK. 2015;10(5):8959.

In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies
Bannas P, Well L, Lenz A, Rissiek B, Haag F, Schmid J, Hochgräfe K, Trepel M, Adam G, Ittrich H, Nolte F
CONTRAST MEDIA MOL I. 2014;9(2):135-42.

Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells
Rissiek B, Danquah W, Haag F, Nolte F
J LEUKOCYTE BIOL. 2014;95(3):543-9.

Nanobodies as modulators of inflammation: potential applications for acute brain injury
Rissiek B, Nolte F, Magnus T
FRONT CELL NEUROSCI. 2014;8:344.

The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs
Menzel S, Rissiek B, Haag F, Goldbaum F, Nolte F
FEBS J. 2013;280(15):3543-50.

DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant
Nyström S, Bråve A, Falkeborn T, Devito C, Rissiek B, Johansson D, Schröder U, Uematsu S, Akira S, Hinkula J, Applequist S
VACCINES-BASEL. 2013;1(4):415-443.

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch Nolte F, Boyer O, Seman M, Adriouch S
J EXP MED. 2010;207(12):2561-2568.

A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.
Scheuplein F, Rissiek B, Driver J, Chen Y, Koch Nolte F, Serreze D
J AUTOIMMUN. 2010;34(2):145-154.

NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells.
Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch Nolte F
J IMMUNOL. 2009;182(5):2898-2908.

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, Cauerhff A, Danquah W, Rissiek B, Scheuplein F, Schwarz N, Adriouch S, Boyer O, Seman M, Licea A, Serreze D, Goldbaum F, Haag F, Koch Nolte F
MED MICROBIOL IMMUN. 2009.

Letzte Aktualisierung aus dem FIS: 23.12.2024 - 23:33 Uhr