Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
Engesser J, Khatri R, Schaub D, Zhao Y, Paust H, Sultana Z, Asada N, Riedel J, Sivayoganathan V, Peters A, Kaffke A, Jauch-Speer S, Goldbeck-Strieder T, Puelles V, Wenzel U, Steinmetz O, Hoxha E, Turner J, Mittrücker H, Wiech T, Huber T, Bonn S, Krebs C, Panzer U
NAT COMMUN. 2024;15(1):8220.

Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease
Gnirck A, Philipp M, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T, Xiong T, Klaus D, Tomczyk P, Al-Bahra M, Menche D, Walkenhorst M, Lantz O, Willing A, Friese M, Huber T, Krebs C, Panzer U, Kurts C, Turner J
NAT COMMUN. 2023;14(1):.

CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
Paust H, Song N, De Feo D, Asada N, Tuzlak S, Zhao Y, Riedel J, Hellmig M, Sivayoganathan A, Peters A, Kaffke A, Borchers A, Wenzel U, Steinmetz O, Tiegs G, Meister E, Mack M, Kurts C, von Vietinghoff S, Lindenmeyer M, Hoxha E, Stahl R, Huber T, Bonn S, Meyer-Schwesinger C, Wiech T, Turner J, Becher B, Krebs C, Panzer U
SCI TRANSL MED. 2023;15(687):.

Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury
Riedel J, Robben L, Paust H, Zhao Y, Asada N, Song N, Peters A, Kaffke A, Borchers A, Tiegs G, Seifert L, Tomas N, Hoxha E, Wenzel U, Huber T, Wiech T, Turner J, Krebs C, Panzer U
JCI INSIGHT. 2023;8(1):.

Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites
Shaikh N, Waterhölter A, Gnirck A, Becker M, Adamiak V, Henneken L, Wunderlich M, Hartmann W, Linnemann L, Huber T, Krebs C, Panzer U, Locksley R, Wilhelm C, Breloer M, Turner J
J EXP MED. 2023;220(12):.

Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection
Bartsch P, Kilian C, Hellmig M, Paust H, Borchers A, Sivayoganathan A, Enk L, Zhao Y, Shaikh N, Büttner H, Wong M, Puelles V, Wiech T, Flavell R, Huber T, Turner J, Bonn S, Huber S, Gagliani N, Mittrücker H, Rohde H, Panzer U, Krebs C
PLOS PATHOG. 2022;18(4):e1010430.

Conventional NK Cells and Type 1 Innate Lymphoid Cells Do Not Influence Pathogenesis of Experimental Glomerulonephritis
Rickassel C, Gnirck A, Shaikh N, Adamiak V, Waterhölter A, Tanriver Y, Neumann K, Huber T, Gasteiger G, Panzer U, Turner J
J IMMUNOL. 2022;208(7):1585-1594.

Validation of a Prospective Urinalysis-Based Prediction Model for ICU Resources and Outcome of COVID-19 Disease: A Multicenter Cohort Study
Gross O, Moerer O, Rauen T, Böckhaus J, Hoxha E, Jörres A, Kamm M, Elfanish A, Windisch W, Dreher M, Floege J, Kluge S, Schmidt-Lauber C, Turner J, Huber S, Addo M, Scheithauer S, Friede T, Braun G, Huber T, Blaschke S
J CLIN MED. 2021;10(14):.

„Coronavirus-disease-2019“-Pandemie aus nephrologischer Perspektive
Hoxha E, Suling A, Turner J, Haubitz M, Floege J, Huber T, Galle J
INTERNIST. 2021;62(7):718-724.

COVID-19 Prevalence and Mortality in Chronic Dialysis Patients
Hoxha E, Suling A, Turner J, Haubitz M, Floege J, Huber T, Galle J
DTSCH ARZTEBL INT. 2021;118(11):195-196.

Tissue-specific therapy in immune-mediated kidney diseases: new ARGuments for targeting the IL-23/IL-17 axis
Krebs C, Turner J, Riedel J, Panzer U
J CLIN INVEST. 2021;131(12):.

Lack of Evidence for an Association between Previous HEV Genotype-3 Exposure and Glomerulonephritis in General
Pischke S, Tamanaei S, Mader M, Wiesch J, Petersen-Benz C, Haddad M, Addo M, Schmidt T, Huber T, Krebs C, Steinmetz O, Turner J, Hoxha E, Horvatits T
PATHOGENS. 2021;11(1):.

T helper cell trafficking in autoimmune kidney diseases
Riedel J, Turner J, Panzer U
CELL TISSUE RES. 2021;385(2):281-292.

IL-17 receptor c signaling controls CD4⁺T_H17 immune responses and tissue injury in immune-mediated kidney diseases
Schmidt T, Luebbe J, Kilian C, Riedel J, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell R, Gagliani N, Pelzcar P, Huber S, Huber T, Turner J, Paust H, Krebs C, Panzer U
J AM SOC NEPHROL. 2021;32(12):3081-3098.

Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs
Solagna F, Tezze C, Lindenmeyer M, Lu S, Wu G, Liu S, Zhao Y, Mitchell R, Meyer C, Omairi S, Kilic T, Paolini A, Ritvos O, Pasternack A, Matsakas A, Kylies D, Wiesch J, Turner J, Wanner N, Nair V, Eichinger F, Menon R, Martin I, Klinkhammer B, Hoxha E, Cohen C, Tharaux P, Boor P, Ostendorf T, Kretzler M, Sandri M, Kretz O, Puelles V, Patel K, Huber T
J CLIN INVEST. 2021;131(11):.

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Zhao Y, Kilian C, Turner J, Bosurgi L, Roedl K, Bartsch P, Gnirck A, Cortesi F, Schultheiß C, Hellmig M, Enk L, Hausmann F, Borchers A, Wong M, Paust H, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur Wiesch J, Puelles V, Sperhake J, Addo M, Lohse A, Binder M, Huber S, Huber T, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs C
SCI IMMUNOL. 2021;6(56):.

IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
Kempski J, Giannou A, Riecken K, Zhao L, Steglich B, Lücke J, Garcia-Perez L, Karstens K, Wöstemeier A, Nawrocki M, Pelczar P, Witkowski M, Nilsson S, Konczalla L, Shiri A, Kempska J, Wahib R, Brockmann L, Huber P, Gnirck A, Turner J, Zazara D, Arck P, Stein A, Simon R, Daubmann A, Meiners J, Perez D, Strowig T, Koni P, Kruglov A, Sauter G, Izbicki J, Guse A, Roesch T, Lohse A, Flavell R, Gagliani N, Huber S
GASTROENTEROLOGY. 2020;159(4):1417-1430.e3.

Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease
Krebs C, Reimers D, Zhao Y, Paust H, Bartsch P, Nuñez S, Rosemblatt M, Hellmig M, Kilian C, Borchers A, Enk L, Zinke M, Becker M, Schmid J, Klinge S, Wong M, Puelles V, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer M, Cohen C, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner J, Riedel J, Huber S, Gagliani N, Huber T, Wiech T, Rohde H, Bono M, Bonn S, Panzer U, Mittrücker H
SCI IMMUNOL. 2020;5(50):.

IL-33 facilitates rapid expulsion of the parasitic nematode Strongyloides ratti from the intestine via ILC2- and IL-9-driven mast cell activation
Meiners J, Reitz M, Rüdiger N, Turner J, Heepmann L, Rudolf L, Hartmann W, McSorley H, Breloer M
PLOS PATHOG. 2020;16(12):e1009121.

Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy
Xiong T, Attar M, Gnirck A, Wunderlich M, Becker M, Rickassel C, Puelles V, Meyer-Schwesinger C, Wiech T, Nies J, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber T, Panzer U, Turner J
KIDNEY INT. 2020;98(3):615-629.

Endogenous IL-22 is dispensable for experimental glomerulonephritis
Gnirck A, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld J, Huber S, Panzer U, Turner J
AM J PHYSIOL-RENAL. 2019;316(4):F712-F722.

Natural Killer Cells in Kidney Health and Disease
Turner J, Rickassel C, Healy H, Kassianos A
FRONT IMMUNOL. 2019;10:587.

T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus
Düster M, Becker M, Gnirck A, Wunderlich M, Panzer U, Turner J
EUR J IMMUNOL. 2018;48(8):1364-1375.

IL-17C/IL-17 Receptor E Signaling in CD4 T Cells Promotes T17 Cell-Driven Glomerular Inflammation
Krohn S, Nies J, Kapffer S, Schmidt T, Riedel J, Kaffke A, Peters A, Steinmetz O, Krebs C, Turner J, Brix S, Paust H, Stahl R, Panzer U
J AM SOC NEPHROL. 2018;29(4):1210-1222.

Tissue-Resident Lymphocytes in the Kidney
Turner J, Becker M, Mittrücker H, Panzer U
J AM SOC NEPHROL. 2018;29(2):389-399.

Innate lymphoid cells: key players in tissue-specific immunity
Turner J, Gasteiger G
SEMIN IMMUNOPATHOL. 2018;40(4):315-317.

Innate lymphoid cells in autoimmunity and chronic inflammatory diseases.
Xiong T, Turner J
SEMIN IMMUNOPATHOL. 2018.

IL-33-Mediated Expansion of Type 2 Innate Lymphoid Cells Protects from Progressive Glomerulosclerosis
Riedel J, Becker M, Kopp K, Düster M, Brix S, Meyer-Schwesinger C, Kluth L, Gnirck A, Attar M, Krohn S, Fehse B, Stahl R, Panzer U, Turner J
J AM SOC NEPHROL. 2017;28(7):2068-2080.

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
KIDNEY INT. 2016;89(1):158-166.

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.

Plasticity of Th17 Cells in Autoimmune Kidney Diseases
Krebs C, Turner J, Paust H, Kapffer S, Koyro T, Krohn S, Ufer F, Friese M, Flavell R, Stockinger B, Steinmetz O, Stahl R, Huber S, Panzer U
J IMMUNOL. 2016;197(2):449-57.

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN
Paust H, Riedel J, Krebs C, Turner J, Brix S, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein S, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H, Steinmetz O, Stahl R, Panzer U
J AM SOC NEPHROL. 2016;27(7):1933-42.

IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases
Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U
J AM SOC NEPHROL. 2016;27(12):3666-3677.

Immune Mechanisms in Arterial Hypertension
Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H
J AM SOC NEPHROL. 2016;27(3):677-86.

CXCL5 drives neutrophil recruitment in TH17-mediated GN
Disteldorf E, Krebs C, Paust H, Turner J, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz O, Peters A, Bennstein S, Kaffke A, Llanto C, Lira S, Mittrücker H, Stahl R, Kurts C, Kaufmann S, Panzer U
J AM SOC NEPHROL. 2015;26(1):55-66.

Glomerulopathy Induced by Immunization with a Peptide Derived from the Goodpasture Antigen α3IV-NC1
Hopfer H, Hünemörder S, Treder J, Turner J, Paust H, Meyer-Schwesinger C, Hopfer U, Sachs M, Peters A, Bucher-Kocaoglu B, Ahrens S, Panzer U, Mittrücker H
J IMMUNOL. 2015;194(8):3646-55.

Function of the Th17/interleukin-17A immune response in murine lupus nephritis
Schmidt T, Paust H, Krebs C, Turner J, Kaffke A, Bennstein S, Koyro T, Peters A, Velden J, Hünemörder S, Haag F, Steinmetz O, Mittrücker H, Stahl R, Panzer U
ARTHRITIS RHEUMATOL. 2015;67(2):475-87.

Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
Hirota K, Turner J, Villa M, Duarte J, Demengeot J, Steinmetz O, Stockinger B
NAT IMMUNOL. 2013;14(4):372-379.

MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN
Krebs C, Kapffer S, Paust H, Schmidt T, Bennstein S, Peters A, Stege G, Brix S, Meyer-Schwesinger C, Müller R, Turner J, Steinmetz O, Wolf G, Stahl R, Panzer U
J AM SOC NEPHROL. 2013;24(12):1955-65.

IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
Turner J, Morrison P, Wilhelm C, Wilson M, Ahlfors H, Renauld J, Panzer U, Helmby H, Stockinger B
J EXP MED. 2013;210(13):2951-65.

IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection
Turner J, Stockinger B, Helmby H
PLOS PATHOG. 2013;9(10):e1003698.

Characterization of the renal CD4(+) T-cell response in experimental autoimmune glomerulonephritis.
Hopfer H, Holzer J, Hünemörder S, Paust H, Sachs M, Meyer-Schwesinger C, Turner J, Panzer U, Mittrücker H
KIDNEY INT. 2012;82(1):60-71.

CCR5 deficiency does not reduce hypertensive end-organ damage in mice
Krebs C, Fraune C, Schmidt-Haupt R, Turner J, Panzer U, Quang M, Tannapfel A, Velden J, Stahl R, Wenzel U
AM J HYPERTENS. 2012;25(4):479-486.

Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis.
Paust H, Turner J, Riedel J, Disteldorf E, Peters A, Schmidt T, Krebs C, Velden J, Mittrücker H, Steinmetz O, Stahl R, Panzer U
KIDNEY INT. 2012;82(1):72-83.

Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN.
Riedel J, Paust H, Turner J, Tittel A, Krebs C, Disteldorf E, Wegscheid C, Tiegs G, Velden J, Mittrücker H, Garbi N, Stahl R, Steinmetz O, Kurts C, Panzer U
J AM SOC NEPHROL. 2012;23(12):1987-2000.

IL-17A production by renal γδ T cells promotes kidney injury in crescentic GN.
Turner J, Krebs C, Tittel A, Paust H, Meyer-Schwesinger C, Bennstein S, Steinmetz O, Prinz I, Magnus T, Korn T, Stahl R, Kurts C, Panzer U
J AM SOC NEPHROL. 2012;23(9):1486-1495.

Protective role for CCR5 in murine lupus nephritis.
Turner J, Paust H, Mathey S, Bramke P, Krebs C, Steinmetz O, Velden J, Haag F, Stahl R, Panzer U
AM J PHYSIOL-RENAL. 2012;302(11):1503-1515.

Renal IL-17 expression in human ANCA-associated glomerulonephritis.
Velden J, Paust H, Hoxha E, Turner J, Steinmetz O, Wolf G, Jabs W, Özcan F, Beige J, Heering P, Schröder S, Kneißler U, Disteldorf E, Mittrücker H, Stahl R, Helmchen U, Panzer U
AM J PHYSIOL-RENAL. 2012;302(12):1663-1673.

The many lives of IL-9: a question of survival?
Wilhelm C, Turner J, Jacques V, Stockinger B
NAT IMMUNOL. 2012;13(7):637-641.

ISN Forefronts Symposium 2010 in Sylt, Germany: 'Induction and Resolution of Renal Inflammation'
Panzer U, Turner J, Steinmetz O, Kurts C, Johnson R, Stahl R
KIDNEY INT. 2011;79(8):807-813.

Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
Paust H, Ostmann A, Erhardt A, Turner J, Velden J, Mittrücker H, Sparwasser T, Panzer U, Tiegs G
KIDNEY INT. 2011;80(2):154-164.

Glomerulonephritis therapy: is there a role for green tea?
Turner J
KIDNEY INT. 2011;80(6):563-564.

Micafungin therapy in a critically ill, morbidly obese patient.
Zomp A, Bookstaver P, Ahmed Y, Turner J, King C
J ANTIMICROB CHEMOTH. 2011;66(11):2678-2680.

Staying on top of things right from the start: the obsessive-compulsive disorder of regulatory T cells.
Steinmetz O, Turner J, Panzer U
J AM SOC NEPHROL. 2010;21(1):6-7.

The Th17 immune response in renal inflammation.
Turner J, Paust H, Steinmetz O, Panzer U
KIDNEY INT. 2010;77(12):1070-1075.

CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
Turner J, Paust H, Steinmetz O, Peters A, Riedel J, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker H, Tiegs G, Stahl R, Panzer U
J AM SOC NEPHROL. 2010;21(6):974-985.

Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases.
Panzer U, Steinmetz O, Turner J, Meyer-Schwesinger C, von Ruffer C, Meyer T, Zahner G, Gómez-Guerrero C, Schmid R, Helmchen U, Moeckel G, Wolf G, Stahl R, Thaiss F
AM J PHYSIOL-RENAL. 2009.

The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis.
Paust H, Turner J, Steinmetz O, Peters A, Heymann F, Hölscher C, Wolf G, Kurts C, Mittrücker H, Stahl R, Panzer U
J AM SOC NEPHROL. 2009;20(5):969-979.

CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.
Steinmetz O, Turner J, Paust H, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer T, Helmchen U, Mittrücker H, Stahl R, Panzer U
J IMMUNOL. 2009;183(7):4693-4704.

15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells
Panzer U, Zahner G, Wienberg U, Steinmetz O, Peters A, Turner J, Paust H, Wolf G, Stahl R, Schneider A
NEPHROL DIAL TRANSPL. 2008;23(12):3776-85.

CCR5 deficiency aggravates crescentic glomerulonephritis in mice.
Turner J, Paust H, Steinmetz O, Peters A, Meyer-Schwesinger C, Heymann F, Helmchen U, Fehr S, Horuk R, Wenzel U, Kurts C, Mittrücker H, Stahl R, Panzer U
J IMMUNOL. 2008;181(9):6546-6556.

Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Panzer U, Steinmetz O, Paust H, Meyer-Schwesinger C, Peters A, Turner J, Zahner G, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl R
J AM SOC NEPHROL. 2007;18(7):2071-2084.

Rituximab removes intrarenal B cell clusters in patients with renal vascular allograft rejection.
Steinmetz O, Lange-Hüsken F, Turner J, Vernauer A, Helmchen U, Stahl R, Thaiss F, Panzer U
TRANSPLANTATION. 2007;84(7):842-850.

Targeting of Th1-associated chemokine receptors CXCR3 and CCR5 as therapeutic strategy for inflammatory diseases.
Turner J, Steinmetz O, Stahl R, Panzer U
MINI-REV MED CHEM. 2007;7(11):1089-1096.

Cytosolic Cl- ions in the regulation of secretory and endocytotic activity in melanotrophs from mouse pituitary tissue slices
Turner J, Sedej S, Rupnik M, Turner J
J PHYSIOL-LONDON. 2005;566(Pt 2):443-53.

Letzte Aktualisierung aus dem FIS: 23.12.2024 - 23:35 Uhr